The plasma miRNAome in ADNI: Signatures to aid the detection of at-risk individuals.

Autor: Krüger DM; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Bioinformatics Unit, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Pena-Centeno T; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Bioinformatics Unit, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Liu S; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Park T; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Kaurani L; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Pradhan R; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Huang YN; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Risacher SL; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Burkhardt S; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Schütz AL; Research Group for Genome Dynamics in Brain Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Wan Y; Perelman School of Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Shaw LM; Perelman School of Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Brodsky AS; Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Warren Alpert Medical School at Brown University, Providence, Rhode Island, USA., DeStefano AL; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Lin H; Department of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA., Schroeder R; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Krunic A; Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Hempel N; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Sananbenesi F; Research Group for Genome Dynamics in Brain Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Blusztajn JK; Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Saykin AJ; Department of Radiology and Imaging Sciences and the Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Delalle I; Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Nho K; Department of Radiology and Imaging Sciences and the Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA., Fischer A; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department for Psychiatry and Psychotherapy, University Medical Center of Göttingen, Georg-August University, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany.; German Center for Cardiovascular Diseases (DZKH) Göttingen, Göttingen, Germany.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Nov; Vol. 20 (11), pp. 7479-7494. Date of Electronic Publication: 2024 Sep 18.

PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer's disease.

Autor: Schröder S; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Fuchs U; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Gisa V; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Pena T; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Bioinformatics Unit, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Krüger DM; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Bioinformatics Unit, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Hempel N; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Burkhardt S; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Salinas G; NGS- Integrative Genomics Core Unit, Institute of Pathology, University Medical Center, Göttingen, Germany., Schütz AL; Research Group for Genome Dynamics in Brain Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Delalle I; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 670 Albany Street, Boston, MA, 02118, USA., Sananbenesi F; Research Group for Genome Dynamics in Brain Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Fischer A; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany. afische2@gwdg.de.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany. afische2@gwdg.de.; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany. afische2@gwdg.de.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2024 Aug 29; Vol. 148 (1), pp. 32. Date of Electronic Publication: 2024 Aug 29.

Formation of memory assemblies through the DNA-sensing TLR9 pathway.

Autor: Jovasevic V; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Wood EM; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA., Cicvaric A; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA., Zhang H; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA., Petrovic Z; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA., Carboncino A; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA., Parker KK; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA., Bassett TE; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA., Moltesen M; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; PROMEMO, Aarhus University, Aarhus, Denmark.; DANDRITE, Aarhus University, Aarhus, Denmark., Yamawaki N; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; PROMEMO, Aarhus University, Aarhus, Denmark.; DANDRITE, Aarhus University, Aarhus, Denmark., Login H; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; PROMEMO, Aarhus University, Aarhus, Denmark.; DANDRITE, Aarhus University, Aarhus, Denmark., Kalucka J; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; PROMEMO, Aarhus University, Aarhus, Denmark.; DANDRITE, Aarhus University, Aarhus, Denmark., Sananbenesi F; Department for Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases, University Medical Center, Göttingen, Germany.; Cluster of Excellence MBExC, University of Göttingen, Göttingen, Germany., Zhang X; Computational Genomics Core, Albert Einstein College of Medicine, Bronx, NY, USA., Fischer A; Department for Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases, University Medical Center, Göttingen, Germany.; Cluster of Excellence MBExC, University of Göttingen, Göttingen, Germany., Radulovic J; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA. jelena.radulovic@einsteinmed.edu.; Department of Biomedicine, Aarhus University, Aarhus, Denmark. jelena.radulovic@einsteinmed.edu.; PROMEMO, Aarhus University, Aarhus, Denmark. jelena.radulovic@einsteinmed.edu.; DANDRITE, Aarhus University, Aarhus, Denmark. jelena.radulovic@einsteinmed.edu.; Department of Psychiatry and Behavioral Sciences, Psychiatry Research Institute Montefiore Einstein (PRIME), Albert Einstein College of Medicine, Bronx, NY, USA. jelena.radulovic@einsteinmed.edu.

Publikováno v: Nature [Nature] 2024 Apr; Vol. 628 (8006), pp. 145-153. Date of Electronic Publication: 2024 Mar 27.

A microRNA signature that correlates with cognition and is a target against cognitive decline.

Autor: Islam MR; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Kaurani L; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.; Department for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany., Berulava T; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Heilbronner U; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Budde M; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Centeno TP; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Elerdashvili V; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Zafieriou MP; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Göttingen, Germany., Benito E; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Sertel SM; Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, Germany., Goldberg M; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Senner F; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, München, Germany., Kalman JL; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, München, Germany., Burkhardt S; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Oepen AS; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Sakib MS; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Kerimoglu C; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Wirths O; Department for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany., Bickeböller H; Department of Genetic Epidemiology, University Medical Center Göttingen, Göttingen, Germany., Bartels C; Department for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany., Brosseron F; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Neurodegeneration and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Buerger K; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Cosma NC; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany., Fliessbach K; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Neurodegeneration and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Heneka MT; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Neurodegeneration and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Janowitz D; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Kilimann I; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Kleinedam L; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Neurodegeneration and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Laske C; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Metzger CD; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany.; Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany., Munk MH; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Perneczky R; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, München, Germany.; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.; Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK., Peters O; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Priller J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany., Rauchmann BS; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, München, Germany., Roy N; German Center for Neurodegenerative Diseases, Bonn, Germany., Schneider A; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Neurodegeneration and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Spottke A; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany., Spruth EJ; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany., Teipel S; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Tscheuschler M; Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany., Wagner M; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Neurodegeneration and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Wiltfang J; Department for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department of Medical Sciences, Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Düzel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany., Jessen F; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Köln, Germany., Rizzoli SO; Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany., Zimmermann WH; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany.; DZKH (German Center for Cardiovascular Diseases), Göttingen, Germany., Schulze TG; Department for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, München, Germany., Falkai P; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, München, Germany., Sananbenesi F; Department for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, München, Germany.; German Center for Neurodegenerative Diseases, Research Group for Genome Dynamics in Brain Diseases, Göttingen, Germany., Fischer A; Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.; Department for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; German Center for Neurodegenerative Diseases, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2021 Nov 08; Vol. 13 (11), pp. e13659. Date of Electronic Publication: 2021 Oct 11.

Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501.

Autor: Goldberg M; German Center for Neurodegenerative Diseases, Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Von Siebold Str 3A, 37075, Goettingen, Germany., Islam MR; German Center for Neurodegenerative Diseases, Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Von Siebold Str 3A, 37075, Goettingen, Germany. mrezaulislam33@gmail.com., Kerimoglu C; German Center for Neurodegenerative Diseases, Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Von Siebold Str 3A, 37075, Goettingen, Germany., Lancelin C; Developmental Neurobiology Laboratory, European Neuroscience Institute, Grisebachstrasse 5, 37077, Goettingen, Germany., Gisa V; German Center for Neurodegenerative Diseases, Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Von Siebold Str 3A, 37075, Goettingen, Germany., Burkhardt S; German Center for Neurodegenerative Diseases, Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Von Siebold Str 3A, 37075, Goettingen, Germany., Krüger DM; German Center for Neurodegenerative Diseases, Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Von Siebold Str 3A, 37075, Goettingen, Germany., Marquardt T; Interfaculty Chair for Neurobiological Research, RWTH Aachen University: Medical Faculty, Clinic for Neurology & Faculty for Mathematics, Computer and Natural Sciences, Institute for Biology 2, Worringer Weg 3, 52074, Aachen, Germany., Malchow B; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilians-University Munich, Nußbaumstr. 7, 80336, München, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center, Von-Siebold-Str. 5, 37075, Göttingen, Germany., Schmitt A; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilians-University Munich, Nußbaumstr. 7, 80336, München, Germany.; Laboratory of Neuroscience (LIM27), Institute of Psychiatry, University of Sao Paulo, 05403-010, São Paulo, Brazil., Falkai P; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilians-University Munich, Nußbaumstr. 7, 80336, München, Germany., Sananbenesi F; German Center for Neurodegenerative Diseases, Research Group for Genome Dynamics in Brain Diseases, Von Siebold Str. 3A, 37075, Göttingen, Germany., Fischer A; German Center for Neurodegenerative Diseases, Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Von Siebold Str 3A, 37075, Goettingen, Germany. andre.fischer@dzne.de.; Department of Psychiatry and Psychotherapy, University Medical Center, Von-Siebold-Str. 5, 37075, Göttingen, Germany. andre.fischer@dzne.de.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany. andre.fischer@dzne.de.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2021 Oct 08; Vol. 11 (1), pp. 514. Date of Electronic Publication: 2021 Oct 08.