Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sanam, Movassaghi"'
Autor:
Jahanzaib Arshad, Kelvin K. H. Tong, Sanam Movassaghi, Tilo Söhnel, Stephen M. F. Jamieson, Muhammad Hanif, Christian G. Hartinger
Publikováno v:
Molecules, Vol 26, Iss 4, p 833 (2021)
RuII(cym)Cl (cym = η6-p-cymene) complexes of pyridinecarbothioamides have shown potential for development as orally active anticancer metallodrugs, underlined by their high selectivity towards plectin as the molecular target. In order to investigate
Externí odkaz:
https://doaj.org/article/0c29b966a1e74fa9bb1d5c7c6222e631
Autor:
Md. Salman Shakil, Shahida Parveen, Zohaib Rana, Fearghal Walsh, Sanam Movassaghi, Tilo Söhnel, Mayur Azam, Muhammad Ashraf Shaheen, Stephen M. F. Jamieson, Muhammad Hanif, Rhonda J. Rosengren, Christian G. Hartinger
Publikováno v:
Biomedicines, Vol 9, Iss 2, p 123 (2021)
Hydroxypyr(id)ones are a pharmaceutically important class of compounds that have shown potential in diverse areas of drug discovery. We investigated the 3-hydroxy-4-pyridones 1a–1c and 3-hydroxy-4-thiopyridones 1d–1f as well as their Ru(η6-p-cym
Externí odkaz:
https://doaj.org/article/3583fd1cf73c490da2a40080e038b220
Autor:
Christian G. Hartinger, Sanam Movassaghi, Kelvin K. H. Tong, James H. Lovett, Suresh K. Bhargava, Katja Hummitzsch, Hugh H. Harris, Stephen M. F. Jamieson, Muhammad Hanif, Tilo Söhnel, Matthew P. Sullivan
Publikováno v:
ChemMedChem. 16:3017-3026
We report investigations on the anticancer activity of organometallic [MII/III (η6 -p-cymene/η5 -pentamethylcyclopentadienyl)] (M=Ru, Os, Rh, and Ir) complexes of N-heterocyclic carbenes (NHCs) substituted with a triazolyl moiety. Depending on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92287425c2f49b8edfb89e2e02d7fd3d
https://doi.org/10.1002/cmdc.202100311
https://doi.org/10.1002/cmdc.202100311
Autor:
Zahid Riaz, Betty Y.T. Lee, Julia Stjärnhage, Sanam Movassaghi, Tilo Söhnel, Stephen M.F. Jamieson, Muhammad Ashraf Shaheen, Muhammad Hanif, Christian G. Hartinger
Publikováno v:
Journal of Inorganic Biochemistry. 241:112115
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed20d582a72ee5d81bdd80ca4406a777
https://doi.org/10.1016/j.jinorgbio.2022.112115
https://doi.org/10.1016/j.jinorgbio.2022.112115
Autor:
Sanam Movassaghi, Stephen M. F. Jamieson, Christian G. Hartinger, Ayesha Zafar, Mario Kubanik, Farhana Aman, Adnan Ashraf, Waseeq Ahmad Siddiqui, Jóhannes Reynisson, Muhammad Hanif, Tilo Söhnel
Publikováno v:
Organometallics. 38:361-374
Nonsteroidal antiinflammatory drugs (NSAIDs) have chemopreventive effects in several cancer types, and the oxicam-based NSAIDs meloxicam and piroxicam exhibit potential to treat cancer. We prepared a series of novel oxicams and coordinated them to Ru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52518a71e053840b65b7c6aeff007678
https://doi.org/10.1021/acs.organomet.8b00751
https://doi.org/10.1021/acs.organomet.8b00751
Autor:
Jonathan W. Astin, Muhammad Hanif, Stephen M. F. Jamieson, Shahida Parveen, Euphemia Leung, Tasha R. Steel, Christian G. Hartinger, Gayan Heruka De Zoysa, Annie Yang, Kelvin K. H. Tong, Sanam Movassaghi, David M. Goodman, Vijayalekshmi Sarojini, Tilo Söhnel
Publikováno v:
Chemical Communications. 55:12016-12019
Redox-modulating anticancer drugs allow the exploitation of altered redox biology observed in many cancer cells. We discovered dinuclear RhIII(Cp*) and IrIII(Cp*) complexes that have in vitro anticancer activity superior to cisplatin and the investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47201a98acb906af4753cd2959e512d
https://doi.org/10.1039/c9cc03822a
https://doi.org/10.1039/c9cc03822a
Autor:
Stephen M. F. Jamieson, Rhonda J. Rosengren, Kamal Patel, Muhammad Hanif, Jahanzaib Arshad, Jonathan W. Astin, Sanam Movassaghi, Christian G. Hartinger, Euphemia Leung, Ayesha Zafar, Tilo Söhnel, Vijayalekshmi Sarojini, Zohaib Rana, Jóhannes Reynisson
Publikováno v:
Angewandte Chemie (International ed. in English). 59(34)
The combination of more than one bioactive moiety in a multitargeted anticancer agent may result in synergistic activity of its components. Using this concept, bioorganometallic compounds were designed to feature a metal center, a 2-pyridinecarbothio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f527635805144be1342c6954fac86dd
https://pubmed.ncbi.nlm.nih.gov/32431061
https://pubmed.ncbi.nlm.nih.gov/32431061
Autor:
Christian G. Hartinger, Jóhannes Reynisson, Damian Plażuk, Daniel Tchoń, Andrzej Błauż, Aleksandra Budniok, Kelvin K. H. Tong, Michał Łomzik, Stephen M. F. Jamieson, Barbara Leśniewska, Muhammad Hanif, Ayesha Zafar, Błażej Rychlik, Sanam Movassaghi, Tilo Söhnel, Anna Makal
Publikováno v:
Inorganic Chemistry
Ispinesib is a potent inhibitor of kinesin spindle protein (KSP), which has been identified as a promising target for antimitotic anticancer drugs. Herein, we report the synthesis of half-sandwich complexes of Ru, Os, Rh, and Ir bearing the ispinesib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706c59c51ac9bd51f66f76616e616b8a
https://hdl.handle.net/11089/38809
https://hdl.handle.net/11089/38809
Autor:
Christian G. Hartinger, Hilke Burmeister, Ayesha Zafar, Ingo Ott, Stephen M. F. Jamieson, Daniel M Ayine-Tora, Luciano Oehninger, Tilo Söhnel, Maria V. Babak, Hannah U. Holtkamp, Mario Kubanik, Sanam Movassaghi, Nelson Y. S. Lam, Christian Gaiddon, Dianna Truong, Jóhannes Reynisson
Publikováno v:
Inorganic Chemistry
Inorganic Chemistry, American Chemical Society, 2018, 57 (22), pp.14427-14434. ⟨10.1021/acs.inorgchem.8b02634⟩
Inorganic Chemistry, 2018, 57 (22), pp.14427-14434. ⟨10.1021/acs.inorgchem.8b02634⟩
Inorganic Chemistry, American Chemical Society, 2018, 57 (22), pp.14427-14434. ⟨10.1021/acs.inorgchem.8b02634⟩
Inorganic Chemistry, 2018, 57 (22), pp.14427-14434. ⟨10.1021/acs.inorgchem.8b02634⟩
International audience; The promise of the metal(arene) structure as an anticancer pharmacophore has prompted intensive exploration of this chemical space. While N-heterocyclic carbene (NHC) ligands are widely used in catalysis, they have only recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c64fcd958b568fd362de4c47bb92d2
https://doi.org/10.1021/acs.inorgchem.8b02634
https://doi.org/10.1021/acs.inorgchem.8b02634
Autor:
Sanam Movassaghi, Jason Keng-Ying Tu, Betty Y. T. Lee, Tilo Söhnel, Christian G. Hartinger, Euphemia Leung, Stephen M. F. Jamieson, Muhammad Hanif, Hannah U. Holtkamp
Publikováno v:
Inorganic Chemistry. 57:8521-8529
RuII(η6-arene) compounds carrying bioactive flavonol ligands have shown promising anticancer activity against tumor cells via a multitargeting mode of action, i.e., through interaction with DNA and inhibition of topoisomerase IIα. By introducing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32039db6388d0a0dd2d15ccccd9052b8
https://doi.org/10.1021/acs.inorgchem.8b01187
https://doi.org/10.1021/acs.inorgchem.8b01187