Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Sanae Hasegawa-Ishii"'
Publikováno v:
Frontiers in Neural Circuits, Vol 18 (2024)
The olfactory epithelium (OE) is directly exposed to environmental agents entering the nasal cavity, leaving OSNs prone to injury and degeneration. The causes of olfactory dysfunction are diverse and include head trauma, neurodegenerative diseases, a
Externí odkaz:
https://doaj.org/article/12b984f44d9c42a0862ee6f6bb7b8603
Publikováno v:
Frontiers in Neural Circuits, Vol 18 (2024)
Brain research has progressed with anesthetized animal experiments for a long time. Recent progress in research techniques allows us to measure neuronal activity in awake animals combined with behavioral tasks. The trends became more prominent in the
Externí odkaz:
https://doaj.org/article/eff89356d5c7497dbf11c2a84ef245d5
Autor:
Tomoya Suda, Tomoko Hanawa, Mayuko Tanaka, Yasunori Tanji, Kazuhiko Miyanaga, Sanae Hasegawa-Ishii, Ken Shirato, Takako Kizaki, Takeaki Matsuda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract There is an urgent need to develop phage therapies for multidrug-resistant bacterial infections. However, although bacteria have been shown to be susceptible to phage therapy, phage therapy is not sufficient in some cases. PhiMR003 is a meth
Externí odkaz:
https://doaj.org/article/83bea2fbe6bb4ee394c76e3aeeb9f202
Autor:
Megumi Kishimoto-Urata, Shinji Urata, Ryoji Kagoya, Fumiaki Imamura, Shin Nagayama, Rachel A. Reyna, Junki Maruyama, Tatsuya Yamasoba, Kenji Kondo, Sanae Hasegawa-Ishii, Slobodan Paessler
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb,
Externí odkaz:
https://doaj.org/article/12fd7fed7a19441e9c5c48c110348f87
Autor:
Atsuyoshi Shimada, Makiko Murata, Sayaka Aoyagi, Hinami Asano, Aki Obara, Sanae Hasegawa-Ishii
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 1380-1390 (2022)
Systemic inflammation affects brain functions. In our previous study in which lipopolysaccharide (LPS) was injected intraperitoneally into mice at sublethal doses, choroid plexus macrophages produced interleukin-1β and stimulated neighboring stromal
Externí odkaz:
https://doaj.org/article/6ad1d71f85d94a68b7cb848429ff1431
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract A growing body of evidence suggests a relationship between olfactory dysfunction and the pathogenesis of mental disorders. Our previous studies indicated that chronic nasal inflammation caused loss of olfactory sensory neurons and gross atro
Externí odkaz:
https://doaj.org/article/782583b7c1144d43b613712060a30748
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 520-528 (2021)
Sepsis-associated encephalopathy (SAE) is characterized as diffuse brain dysfunction in patients with excessive systemic inflammatory reaction to an infection. In our previous studies using a mouse model of SAE with intraperitoneal injection of lipop
Externí odkaz:
https://doaj.org/article/d07a8e86967d4c70943346ca3debafa7
Autor:
Shoko Morita-Takemura, Kazuki Nakahara, Sanae Hasegawa-Ishii, Ayami Isonishi, Kouko Tatsumi, Hiroaki Okuda, Tatsuhide Tanaka, Masahiro Kitabatake, Toshihiro Ito, Akio Wanaka
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-13 (2019)
Abstract Background Circulating endotoxins including lipopolysaccharides (LPS) cause brain responses such as fever and decrease of food and water intake, while pre-injection of endotoxins attenuates these responses. This phenomenon is called endotoxi
Externí odkaz:
https://doaj.org/article/0c82219c2dd74a5f92c57881f4da1d99
Autor:
Keiko Unno, Yoshio Muguruma, Koichi Inoue, Tomokazu Konishi, Kyoko Taguchi, Sanae Hasegawa-Ishii, Atsuyoshi Shimada, Yoriyuki Nakamura
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 193 (2020)
By comprehensively measuring changes in metabolites in the hippocampus of stress-loaded mice, we investigated the reasons for stress vulnerability and the effect of theanine, i.e., an abundant amino acid in tea leaves, on the metabolism. Stress sensi
Externí odkaz:
https://doaj.org/article/58efa3277e2d475cb87e86206b135ae0
Autor:
Keiko Unno, Yoshiichi Takagi, Tomokazu Konishi, Mitsuhiro Suzuki, Akiyuki Miyake, Takumi Kurotaki, Tadashi Hase, Shinichi Meguro, Atsuyoshi Shimada, Sanae Hasegawa-Ishii, Monira Pervin, Kyoko Taguchi, Yoriyuki Nakamura
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5579 (2020)
Senescence-accelerated mouse prone 10 (SAMP10) exhibits cerebral atrophy and depression-like behavior. A line of SAMP10 with spontaneous mutation in the Slc5a2 gene encoding the sodium-glucose cotransporter (SGLT) 2 was named SAMP10/TaSlc-Slc5a2slc (
Externí odkaz:
https://doaj.org/article/a3bc2e216bf84082b6b89f72fbbdad1e