Výsledky vyhledávání - "Sanadelaslam S. A. El-Hddad"

Akademický článek

Design, Molecular Docking, Synthesis, Anticancer and Anti-Hyperglycemic Assessments of Thiazolidine-2,4-diones Bearing Sulfonylthiourea Moieties as Potent VEGFR-2 Inhibitors and PPARγ Agonists

Autor: Mohamed A. Abdelgawad, Khaled El-Adl, Sanadelaslam S. A. El-Hddad, Mostafa M. Elhady, Nashwa M. Saleh, Mohamed M. Khalifa, Fathalla Khedr, Mohamed Alswah, AbdElAziz A. Nayl, Mohammed M. Ghoneim, Nour E. A. Abd El-Sattar

Publikováno v: Pharmaceuticals, Vol 15, Iss 2, p 226 (2022)

Newly designed thiazolidine-2,4-diones 3–7a–c were synthesized, and their anticancer activities were screened against three cancer lines. They showed potent activities against HepG2 compared to the other HCT116 and MCF-7 tumor cell lines. Compoun

Externí odkaz: https://doaj.org/article/c18b326a90404f8caba435121323ff9b

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Design, synthesis, and docking of novel thiazolidine‐2,4‐dione multitarget scaffold as new approach for cancer treatment

Autor: Noura S. Hanafy, Nada A. A. M. Aziz, Sanadelaslam S. A. El‐Hddad, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Amal F. Dawood, Samy Mohamady, Khaled El‐Adl, Sahar Ahmed

Publikováno v: Archiv der Pharmazie.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60f51211120bf6cea6d7c17db478fbbd
https://doi.org/10.1002/ardp.202300137

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Design, synthesis, docking, ADMET profile, and anticancer evaluations of novel thiazolidine-2,4-dione derivatives as VEGFR-2 inhibitors

Autor: Hamada S. Abulkhair, Sanadelaslam S. A. El‐Hddad, Helmy Sakr, Abdel-Ghany A. El-Helby, Mohamed Nasser, Khaled El-Adl

Publikováno v: Archiv der PharmazieREFERENCES. 354(7)

The anticancer activity of novel thiazolidine-2,4-diones was evaluated against HepG2, HCT-116, and MCF-7 cells. Among the tested cancer cell lines, HCT-116 was the most sensitive one to the cytotoxic effect of the new derivatives. In particular, comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4814ea1f87d9f8ad942cac1fdf2e9258
https://pubmed.ncbi.nlm.nih.gov/33788290

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Design, synthesis, molecular docking, anticancer evaluations, and in silico pharmacokinetic studies of novel 5-[(4-chloro/2,4-dichloro)benzylidene]thiazolidine-2,4-dione derivatives as VEGFR-2 inhibitors

Autor: Khaled El-Adl, Rezk R. Ayyad, Mohamed Nasser, Hamada S. Abulkhair, Helmy Sakr, Hazem A. Mahdy, Sanadelaslam S. A. El‐Hddad, Abdel-Ghany A. El-Helby

Publikováno v: Archiv der PharmazieREFERENCES. 354(2)

The anticancer activity of novel thiazolidine-2,4-diones was evaluated against HepG2, HCT-116, and MCF-7 cells. MCF-7 was the most sensitive cell line to the cytotoxicity of the new derivatives. In particular, compounds 18, 12, 17, and 16 were found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2af2a5e3d142b366a022b3cfb99d8c
https://pubmed.ncbi.nlm.nih.gov/33073374

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Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2,4-dione derivatives targeting VEGFR-2 enzyme

Autor: Ibrahim H. Eissa, Sanadelaslam S. A. El‐Hddad, Fatma M.I.A. Shoman, Abdel-Ghany A. El-Helby, Khaled El-Adl, Helmy Sakr

Publikováno v: Bioorganic chemistry. 102

Novel series of 5-benzylidenethiazolidine-2,4-dione derivatives 4a-c-8a-f were designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and MCF-7 cell lines. MCF-7 was the most sensitive cell line to the influence of the new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fdcf7b808a44d70159b388872101852
https://pubmed.ncbi.nlm.nih.gov/32653608

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Design, synthesis, molecular docking, and anticancer evaluations of 1-benzylquinazoline-2,4(1H,3H)-dione bearing different moieties as VEGFR-2 inhibitors

Autor: Helmy Sakr, Abdel-Ghany A. El-Helby, Khaled El-Adl, Sanadelaslam S. A. El‐Hddad

Publikováno v: Archiv der PharmazieREFERENCES. 353(8)

A novel series of 1-benzylquinazoline-2,4(1H,3H)-dione derivatives, 6a,b to 11a-e, was designed, synthesized, and evaluated for their anticancer activity against HepG2, HCT-116, and MCF-7 cells. Compounds 11b, 11e, and 11c were found to be the most p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3802c7ebf1c605231ea1ac3b2e00ba
https://pubmed.ncbi.nlm.nih.gov/32510731

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