Výsledky vyhledávání - "Sana Boujaafar"

Plasma Concentrations and Safety of Lopinavir/Ritonavir in COVID-19 Patients

Autor: Celia Azoulay, Jeremie Zerbit, Solen Kernéis, Laurent Chouchana, Paul Legendre, Rui Batista, Yi Zheng, Sana Boujaafar, Benjamin Terrier, Jean-Marc Treluyer, Lucile Regard, Sihem Benaboud, Nicolas Carlier, Etienne Canouï, Inès Gana, Laure-Hélène Preta

Publikováno v: Therapeutic Drug Monitoring

Background Although the efficacy of lopinavir/ritonavir has not been proven, it has been proposed as an off-label treatment for COVID-19. Previously, it has been reported that the plasma concentrations of lopinavir significantly increase in inflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35638027da5cc925ce78e5a9f889283e
https://doi.org/10.1097/ftd.0000000000000838

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Population Pharmacokinetics of Intravenous Ganciclovir and Oral Valganciclovir in a Pediatric Population To Optimize Dosing Regimens

Autor: Sana Boujaafar, Naïm Bouazza, V. Lopez, Frantz Foissac, Mehdi Oualha, Coralie Briand, Yi Zheng, M. Bendavid, Zeynep Demir, Jean-Marc Treluyer, S Winter, Inès Gana, Sihem Benaboud, Thi Huyen Tram Nguyen, Déborah Hirt, Agathe Béranger, Romain Berthaud

Publikováno v: Antimicrob Agents Chemother

Ganciclovir is indicated for curative or preventive treatment of cytomegalovirus (CMV) infections. This study aimed to characterize ganciclovir pharmacokinetics, following intravenous ganciclovir and oral valganciclovir administration, to optimize do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11464277d51f3ff6722d5e56443c488d
https://doi.org/10.1128/aac.02254-20

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Population pharmacokinetics of intravenous and oral ciprofloxacin in children to optimize dosing regimens

Publikováno v: European journal of clinical pharmacology. 77(11)

This study aimed to characterize pharmacokinetics of intravenous and oral ciprofloxacin in children to optimize dosing scheme.Children treated with ciprofloxacin were included. Pharmacokinetics were described using non-linear mixed-effect modelling a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::927e5995e9f9aa95a0e63f4463c151fa
https://pubmed.ncbi.nlm.nih.gov/34160669

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Population Pharmacokinetics of Intravenous and Oral Acyclovir and Oral Valacyclovir in Pediatric Population To Optimize Dosing Regimens

Autor: Coralie Briand, S Winter, M. Bendavid, Zeynep Demir, Carmen Capito, Mehdi Oualha, Naïm Bouazza, Sana Boujaafar, S Abdalla, Sihem Benaboud, Yi Zheng, Frantz Foissac, Agathe Béranger, Déborah Hirt, Inès Gana, J-M Tréluyer

Publikováno v: Antimicrob Agents Chemother

Acyclovir is an antiviral currently used for the prevention and treatment of herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections. This study aimed to characterize the pharmacokinetics (PK) of acyclovir and its oral prodrug valacycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c4e2542f2cc2bc25c3b10ae3af8336
https://doi.org/10.1128/aac.01426-20

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Predictive Performance of Population Pharmacokinetic Models of Levetiracetam in Children and Evaluation of Dosing Regimen

Autor: Gabrielle Lui, Jean-Marc Tréluyer, Inès Gana, Isabelle Desguerre, Sihem Benaboud, Rima Nabbout, Déborah Hirt, Nicole Chemaly, Manon Tauzin, Cécile Freihuber, Thierry Billette de Villemeur, Sana Boujaafar, Naïm Bouazza, Camille Chenevier-Gobeaux, Yi Zheng

Publikováno v: Journal of Clinical Pharmacology
Journal of Clinical Pharmacology, Wiley, 2021, 61 (10), pp.1366-1375. ⟨10.1002/jcph.1910⟩

International audience; Levetiracetam is a broad-spectrum antiepileptic drug that exhibits high interindividual variability in serum concentrations in children. A population pharmacokinetic approach can be used to explain this variability and optimiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f869c3dd0c510a7514d16e825baae4f
https://pubmed.ncbi.nlm.nih.gov/33997989

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Plasma concentration and safety of lopinavir/ritonavir in patients with Covid-19: a short communication

Autor: Paul Legendre, Rui Batista, Jean-Marc Treluyer, Benjamin Terrier, Inès Gana, Jeremie Zerbit, Solen Kernéis, Laure-Hélène Preta, Celia Azoulay, Laurent Chouchana, Sihem Benaboud, Nicolas Carlier, Etienne Canouï, Lucile Regard, Sana Boujaafar, Yi Zheng

BackgroundLopinavir/ritonavir has been proposed as off-label treatment for Covid-19, although efficacy have not been proven. It has previously been shown that lopinavir plasma concentration is dramatically increased in inflammatory settings. As Covid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56bd22011e6a15709cf112f1f606b756
https://doi.org/10.1101/2020.05.18.20105650

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Development of a simple and rapid method to determine the unbound fraction of dolutegravir, raltegravir and darunavir in human plasma using ultrafiltration and LC-MS/MS

Autor: Radia Aboura, Inès Gana, Naïm Bouazza, Jean-Marc Treluyer, Déborah Hirt, Sihem Benaboud, Frantz Foissac, Sana Boujaafar, Gabrielle Lui, Yi Zheng

Publikováno v: Journal of pharmaceutical and biomedical analysis. 196

Dolutegravir, raltegravir and darunavir are three antiretroviral drugs widely used in combined antiretroviral therapies. These three drugs are highly bound to plasma proteins. Compared to the total concentration, the concentration of unbound drug whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c687e1bc3a95fe6d8774e684c92d8cb
https://pubmed.ncbi.nlm.nih.gov/33571728

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HPLC-MS/MS method for the simultaneous quantification of dolutegravir, elvitegravir, rilpivirine, darunavir, ritonavir, raltegravir and raltegravir-β-d-glucuronide in human plasma

Autor: Jean-Marc Tréluyer, Déborah Hirt, Radia Aboura, Gabrielle Lui, Sihem Benaboud, Naïm Bouazza, Frantz Foissac, Sana Boujaafar, Inès Gana, Yi Zheng

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2020, 182, pp.113119-. ⟨10.1016/j.jpba.2020.113119⟩

Therapeutic drug monitoring (TDM) is essential in the optimization of antiretroviral (ARV) treatments. In this work, we describe a new method for the simultaneous quantification of six molecules: the three novel ARV agents dolutegravir (DTG), elviteg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c6923c424756daf8f2f0a57b32eeb7
https://hal.archives-ouvertes.fr/hal-03489828

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A meropenem pharmacokinetics model in patients with haematological malignancies

Autor: L. Jaffrelot, Adrien Contejean, Sana Boujaafar, Inès Gana, Déborah Hirt, Jean-Marc Treluyer, Solen Kernéis, Remy Gauzit, Didier Bouscary, Lise Willems, Sihem Benaboud, Eric Grignano

Publikováno v: The Journal of antimicrobial chemotherapy. 75(10)

Background Optimal dosing of antibiotics is critical in immunocompromised patients suspected to have an infection. Data on pharmacokinetics (PK) of meropenem in patients with haematological malignancies are scarce. Objectives To optimize dosing regim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6c32f951639f4168ac5187c2f901d1
https://pubmed.ncbi.nlm.nih.gov/32737508

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