Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sana Ahmed-Seghir"'
Autor:
Manisha Jalan, Aman Sharma, Xin Pei, Nils Weinhold, Erika S. Buechelmaier, Yingjie Zhu, Sana Ahmed-Seghir, Abhirami Ratnakumar, Melody Di Bona, Niamh McDermott, Joan Gomez-Aguilar, Kyrie S. Anderson, Charlotte K. Y. Ng, Pier Selenica, Samuel F. Bakhoum, Jorge S. Reis-Filho, Nadeem Riaz, Simon N. Powell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Collisions of the transcription and replication machineries on the same DNA strand can pose a significant threat to genomic stability. These collisions occur in part due to the formation of RNA-DNA hybrids termed R-loops, in which a newly tr
Externí odkaz:
https://doaj.org/article/7cd61270c6534754a1bbd7203bce046c
Autor:
Sana Ahmed-Seghir, Manisha Jalan, Helen E Grimsley, Aman Sharma, Shyam Twayana, Settapong T Kosiyatrakul, Christopher Thompson, Carl L Schildkraut, Simon N Powell
Publikováno v:
eLife, Vol 12 (2023)
When replication forks encounter DNA lesions that cause polymerase stalling, a checkpoint pathway is activated. The ATR-dependent intra-S checkpoint pathway mediates detection and processing of sites of replication fork stalling to maintain genomic i
Externí odkaz:
https://doaj.org/article/994d047302634e5f891f947f1a33a946
Autor:
Barbara Ben Yamin, Philippe Dessen, Caroline Pouvelle, Raphael Corre, Jean Charles Cadoret, Giuseppe Baldacci, Richard D. Wood, Sabine S. Lange, Sergey Nikolaev, Sarita Bhetawal, Jordane Goulas, Quentin Delacour, Emmanuelle Despras, Maria Teresa Mitjavila-Garcia, Andrey A. Yurchenko, Sana Ahmed-Seghir, Patricia Kannouche, Didier Goidin, Nathalie Droin, Junya Tomida
Publikováno v:
EMBO Journal
EMBO Journal, EMBO Press, 2021, 49, pp.8120-8134. ⟨10.15252/embj.2020104543⟩
The EMBO Journal
EMBO Journal, 2021, 49, pp.8120-8134. ⟨10.15252/embj.2020104543⟩
EMBO Journal, EMBO Press, 2021, 49, pp.8120-8134. ⟨10.15252/embj.2020104543⟩
The EMBO Journal
EMBO Journal, 2021, 49, pp.8120-8134. ⟨10.15252/embj.2020104543⟩
The DNA polymerase zeta (Polζ) plays a critical role in bypassing DNA damage. REV3L, the catalytic subunit of Polζ, is also essential in mouse embryonic development and cell proliferation for reasons that remain incompletely understood. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecceeb3ccfb8f90285de395b8fd780e8
https://hal.sorbonne-universite.fr/hal-03353667
https://hal.sorbonne-universite.fr/hal-03353667
Autor:
Manisha Jalan, Juber Patel, Kyrie S Olsen, Sana Ahmed-Seghir, Daniel S Higginson, Jorge S Reis-Filho, Nadeem Riaz, Simon N Powell
Publikováno v:
Cancer Research. 82:5688-5688
Genome instability has long been considered the primary driver of most cancer types. A double strand break (DSB) in DNA can have deleterious consequences for a cell, which if not repaired faithfully, can lead to mutations and chromosomal rearrangemen
Autor:
Caroline Pouvelle, Patricia Kannouche, Agnès Cordonnier, Emmanuelle Despras, Alain Sarasin, Sana Ahmed-Seghir
Publikováno v:
DNA Repair
DNA Repair, Elsevier, 2015, 29, pp.154-165. ⟨10.1016/j.dnarep.2015.02.017⟩
DNA Repair, Elsevier, 2015, 29, pp.154-165. ⟨10.1016/j.dnarep.2015.02.017⟩
Xeroderma pigmentosum variant (XP-V) is a rare genetic disease, characterized by sunlight sensitivity and predisposition to cutaneous malignancies. XP-V is caused by a deficiency in DNA polymerase eta (Polη) that plays a pivotal role in translesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32e60e7e10743aa1510e679790b44de
https://hal.archives-ouvertes.fr/hal-02979091
https://hal.archives-ouvertes.fr/hal-02979091
Autor:
Emmanuelle Despras, Charlène Garandeau, Sana Ahmed-Seghir, Noémie Delrieu, Patricia Kannouche
Publikováno v:
Environmental and molecular mutagenesis. 53(9)
During translesion synthesis (TLS), low-fidelity polymerases of the Y-family polymerases bypass DNA damages that block the progression of conventional processive DNA polymerases, thereby allowing the completion of DNA replication. Among the TLS polym