Zobrazeno 1 - 10
of 94
pro vyhledávání: '"San-pin Wu"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Estrogen and progesterone, acting through their cognate receptors the estrogen receptor α (ERα) and the progesterone receptor (PR) respectively, regulate uterine biology. Using rapid immunoprecipitation and mass spectrometry (RIME) and co-
Externí odkaz:
https://doaj.org/article/f1d18940f90c41139b4b1583edd5eab3
Autor:
Yeongseok Oh, Elvis Quiroz, Tianyuan Wang, Yassmin Medina-Laver, Skylar Montague Redecke, Francisco Dominguez, John P. Lydon, Francesco J. DeMayo, San-Pin Wu
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Endometrial function is dependent on a tight crosstalk between the epithelial and stromal cells of the endometrium. This communication is critical to ensure a fertile uterus and relies on progesterone and estrogen signaling to prepare a receptive ute
Externí odkaz:
https://doaj.org/article/0fa7791da6b044fb83b2d6338c0b99db
Autor:
Vineet K. Maurya, Maria M. Szwarc, David M. Lonard, William E. Gibbons, San-Pin Wu, Bert W. O’Malley, Francesco J. DeMayo, John P. Lydon
Publikováno v:
Frontiers in Reproductive Health, Vol 4 (2022)
Steroid receptor coactivator-3 (SRC-3; also known as NCOA3 or AIB1) is a member of the multifunctional p160/SRC family of coactivators, which also includes SRC-1 and SRC-2. Clinical and cell-based studies as well as investigations on mice have demons
Externí odkaz:
https://doaj.org/article/52e567cba52d40b295aa29f38efea790
Autor:
Rong Li, Xiaoqiu Wang, Zhenyao Huang, Jayani Balaji, Tae Hoon Kim, Tianyuan Wang, Lecong Zhou, Ashley Deleon, Molly E. Cook, Margeaux W. Marbrey, San-Pin Wu, Jae Wook Jeong, Ripla Arora, Francesco J. DeMayo
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103487- (2021)
Summary: The loss of uterine epithelial progesterone receptor (PGR) is crucial for successful embryo implantation in both humans and mice. The two major isoforms PGRA and PGRB have divergent functions under both physiological and pathological conditi
Externí odkaz:
https://doaj.org/article/00666f3e5389487d8c758c6dc7b6bd8e
Autor:
Jianying Li, Pierre R. Bushel, Lin Lin, Kevin Day, Tianyuan Wang, Francesco J. DeMayo, San-Pin Wu, Jian-Liang Li
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Gene expression is controlled by multiple regulators and their interactions. Data from genome-wide gene expression assays can be used to estimate molecular activities of regulators within a model organism and extrapolate them to biological processes
Externí odkaz:
https://doaj.org/article/23c0123353774a9faf428f930b51a0fc
Autor:
Jian Liu, Tianyuan Wang, Chad J. Creighton, San-Pin Wu, Madhumita Ray, Kyathanahalli S. Janardhan, Cynthia J. Willson, Sung-Nam Cho, Patricia D. Castro, Michael M. Ittmann, Jian-Liang Li, Roger J. Davis, Francesco J. DeMayo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
LKB1 is frequently mutated in lung squamous cell carcinomas. Here, the authors show that sole LKB1 depletion is sufficient to drive the development of this cancer, where downstream defective MKK7-JNK1/2 signalling activates the ∆Np63/p63 pathway to
Externí odkaz:
https://doaj.org/article/3c4a64d307334e7da067be3231521b05
Autor:
Sylvia C. Hewitt, San-pin Wu, Tianyuan Wang, Steven L. Young, Thomas E. Spencer, Francesco J. DeMayo
Publikováno v:
Cells, Vol 11, Iss 11, p 1760 (2022)
For pregnancy to be established, uterine cells respond to the ovarian hormones, estrogen, and progesterone, via their nuclear receptors, the estrogen receptor (ESR1) and progesterone receptor (PGR). ESR1 and PGR regulate genes by binding chromatin at
Externí odkaz:
https://doaj.org/article/31d698f5e02d4e458c3eb9aeac15f1e3
Autor:
Chih-Fen Hu, San-Pin Wu, Gu-Jiun Lin, Chi-Chang Shieh, Chih-Sin Hsu, Jing-Wun Chen, Shih-Heng Chen, Jau-Shyong Hong, Shyi-Jou Chen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
While oxidative stress has been linked to multiple sclerosis (MS), the role of superoxide-producing phagocyte NADPH oxidase (Nox2) in central nervous system (CNS) pathogenesis remains unclear. This study investigates the impact of Nox2 gene ablation
Externí odkaz:
https://doaj.org/article/2fbdfd805d7b49819f5ea0ac652c8cd2
Autor:
Ru-pin Alicia Chi, Tianyuan Wang, Chou-Long Huang, San-pin Wu, Steven L. Young, John P. Lydon, Francesco J. DeMayo
Publikováno v:
JCI Insight, Vol 5, Iss 22 (2020)
WNK1 (with no lysine [K] kinase 1) is an atypical kinase protein ubiquitously expressed in humans and mice. A mutation in its encoding gene causes hypertension in humans, which is associated with abnormal ion homeostasis. WNK1 is critical for in vitr
Externí odkaz:
https://doaj.org/article/9cd769b8a4f046ccbce9ce99614ee48b
Autor:
Xiaoqiu Wang, Xilong Li, Tianyuan Wang, San-Pin Wu, Jae-Wook Jeong, Tae Hoon Kim, Steven L. Young, Bruce A. Lessey, Rainer B. Lanz, John P. Lydon, Francesco J. DeMayo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The transcription factor SOX17 is important for uterine gland formation, fertility, and embryo implantation in mouse. Here the authors show that SOX17 is upstream of Indian hedgehog to regulate mouse uterine receptivity, and their analysis of uterine
Externí odkaz:
https://doaj.org/article/c127c07db61c403ebeb300e9a82a357d