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pro vyhledávání: '"San-bo Qin"'
Publikováno v:
Protein and peptide letters. 13(1)
It has been reported that the cooperative binding of calcium ions indicated a local conformational change of the human cytosolic phospholipase A2 (cPLA2) C2 domain (Nalefski et al., (1997) Biochemistry 36, 12011-12018). However its structural evidenc
Sequential conformation changes of chinese hamster ovary dihydrofolate reductase at its active sites
Publikováno v:
Protein and peptide letters. 12(5)
The local fluorescence probes, 2-(p-toluidino)-6-naphthalenesulfonic acid (TNS) and NADPH were employed to detect urea-induced conformation changes at each active site of dihydrofolate reductase (DHFR), respectively. The results indicate that local c