Zobrazeno 1 - 10
of 225
pro vyhledávání: '"San Ming, Wang"'
Autor:
Stephanie Andaluz, Bojin Zhao, Siddharth Sinha, Philip Naderev Panuringan Lagniton, Diogo Alpuim Costa, Xiaofan Ding, Miguel Brito, San Ming Wang
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Admixture occurs between different ethnic human populations. The global colonization in recent centuries by Europeans led to the most significant admixture in human history. While admixture may enhance genetic diversity for better
Externí odkaz:
https://doaj.org/article/422599836d4f4210b48d84ee321e20ee
Autor:
Bojin Zhao, Jiaheng Li, Siddharth Sinha, Zixin Qin, Si Hoi Kou, Fengxia Xiao, Huijun Lei, Tianhui Chen, Wenming Cao, Xiaofan Ding, San Ming Wang
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Genome stability is maintained by the DNA damage repair (DDR) system composed of multiple DNA repair pathways of hundreds of genes. Germline pathogenic variation (PV) in DDR genes damages function of the affected DDR genes, leadin
Externí odkaz:
https://doaj.org/article/9dbb202443294deeae552bed05a49163
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-10 (2024)
Abstract Background Mismatch repair (MMR) system is evolutionarily conserved for genome stability maintenance. Germline pathogenic variants (PVs) in MMR genes that lead to MMR functional deficiency are associated with high cancer risk. Knowing the ev
Externí odkaz:
https://doaj.org/article/56558a63c9c34cb1b10bcf982207b687
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
IntroductionThe DNA damage repair (DDR) system in human genome is pivotal in maintaining genomic integrity. Pathogenic variation (PV) in DDR genes impairs their function, leading to genome instability and increased susceptibility to diseases, especia
Externí odkaz:
https://doaj.org/article/17426feaf18e430a9e58944f98618497
Autor:
San Ming Wang
Publikováno v:
Journal of the National Cancer Center, Vol 3, Iss 1, Pp 14-20 (2023)
Pathogenic BRCA1 and BRCA2 (BRCA) variation is the genetic predisposition for high cancer risk affecting mostly breast and ovarian. BRCA variation information is widely used in clinical diagnosis, treatment, and prevention of BRCA-related cancer. The
Externí odkaz:
https://doaj.org/article/a843faebceb74462a561e4a45225c86e
Publikováno v:
Genes and Diseases, Vol 10, Iss 1, Pp 228-238 (2023)
Abnormal gene expression plays key role in cancer development. A core promoter is located around the transcriptional start site. Through interaction between core promoter sequences and transcriptional factors, core promoter controls transcriptional i
Externí odkaz:
https://doaj.org/article/20c7aeb508504254be0bd5b733b7987b
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-8 (2022)
Abstract BRCA1 mutation is the genetic predisposition in causing genome instability towards cancer. BRCA1 mutation is predominantly germline inherited at the fertilization. However, when the inherited mutation initiates genome instability in the muta
Externí odkaz:
https://doaj.org/article/5485af4bf19b4a3abd61f0c6e0cafd2b
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Bladder cancer is one of the most mortal cancers. Bladder cancer has distinct gene expression signature, highlighting altered gene expression plays important roles in bladder cancer etiology. However, the mechanism for how the reg
Externí odkaz:
https://doaj.org/article/bdf5e239ad8a4e63be9afb1bf9c5e38e
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106122- (2023)
Summary: Functional classification of genetic variants is a key for their clinical applications in patient care. However, abundant variant data generated by the next-generation DNA sequencing technologies limit the use of experimental methods for the
Externí odkaz:
https://doaj.org/article/cf632021ce98436ab7f06255021ddfbb
Autor:
Xiaoyu Wang, San Ming Wang
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background DNA damage repair (DDR) system is vital in maintaining genome stability and survival. DDR consists of over 160 genes in 7 different pathways to repair specific type of DNA damage caused by external and internal damaging factors. T
Externí odkaz:
https://doaj.org/article/91e72b1a329143579ae4dce05000123c