Multi-modal transcriptomic analysis unravels enrichment of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer.

Autor: Sahoo S; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India., Ramu S; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India., Nair MG; Division of Molecular Medicine, St. John's Research Institute, St. John's Medical College, Bangalore, 560012, India., Pillai M; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India.; Current affiliation: Feinberg School of Medicine, Northwestern University, Chicago, 60611, USA., San Juan BP; Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia., Milioli HZ; Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia., Mandal S; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India., Naidu CM; Division of Molecular Medicine, St. John's Research Institute, St. John's Medical College, Bangalore, 560012, India., Mavatkar AD; Division of Molecular Medicine, St. John's Research Institute, St. John's Medical College, Bangalore, 560012, India., Subramaniam H; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India., Neogi AG; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India., Chaffer CL; Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia.; University of New South Wales, UNSW Medicine, UNSW Sydney, NSW, 2052, Australia., Prabhu JS; Division of Molecular Medicine, St. John's Research Institute, St. John's Medical College, Bangalore, 560012, India., Somarelli JA; Department of Medicine, Duke University, Durham, NC 27708, USA., Jolly MK; Department of Bioengineering, Indian Institute of Science, Bangalore, 560012, India.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 02. Date of Electronic Publication: 2023 Oct 02.

Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning.

Autor: Burkhardt DB; Department of Genetics, Yale University, New Haven, Connecticut.; Cellarity, Somerville, Massachusetts., San Juan BP; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.; St Vincent's Clinical School, UNSW Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia., Lock JG; School of Medical Sciences, Faculty of Medicine and Health, UNSW Sydney, Kensington, New South Wales, Australia., Krishnaswamy S; Department of Genetics, Yale University, New Haven, Connecticut.; Department of Computer Science, Computational Biology Bioinformatics Program, Applied Math Program, Yale University, New Haven, Connecticut., Chaffer CL; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.; St Vincent's Clinical School, UNSW Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia.

Publikováno v: Cancer discovery [Cancer Discov] 2022 Aug 05; Vol. 12 (8), pp. 1847-1859.

IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization.

Autor: Castaño Z; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., San Juan BP; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia., Spiegel A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Pant A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., DeCristo MJ; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Laszewski T; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Ubellacker JM; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Janssen SR; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Dongre A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Reinhardt F; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Henderson A; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Del Rio AG; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gifford AM; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Herbert ZT; Molecular Biology Core Facilities, Dana-Farber Cancer Institute, Boston, MA, USA., Hutchinson JN; Department of Biostatistics, Harvard T.H. Chan, School of Public Health, Boston, MA, USA., Weinberg RA; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; MIT Department of Biology and Ludwig/MIT Center for Molecular Oncology, Cambridge, MA, USA., Chaffer CL; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia. c.chaffer@garvan.org.au.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA. c.chaffer@garvan.org.au., McAllister SS; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. smcallister1@bwh.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. smcallister1@bwh.harvard.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. smcallister1@bwh.harvard.edu.; Harvard Stem Cell Institute, Cambridge, MA, USA. smcallister1@bwh.harvard.edu.

Publikováno v: Nature cell biology [Nat Cell Biol] 2018 Sep; Vol. 20 (9), pp. 1084-1097. Date of Electronic Publication: 2018 Aug 27.

The bHLH factors Dpn and members of the E(spl) complex mediate the function of Notch signalling regulating cell proliferation during wing disc development.

Autor: San Juan BP; Centro de Biología Molecular Severo Ochoa (CSIC/UAM) C/Nicolás Cabrera 1 , 28049 Madrid , Spain., Andrade-Zapata I, Baonza A

Publikováno v: Biology open [Biol Open] 2012 Jul 15; Vol. 1 (7), pp. 667-76. Date of Electronic Publication: 2012 May 30.