An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism.

Autor: Ptacin JL; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA. jptacin@gmail.com., Caffaro CE; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Ma L; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., San Jose Gall KM; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Aerni HR; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Acuff NV; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Herman RW; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Pavlova Y; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Pena MJ; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Chen DB; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Koriazova LK; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Shawver LK; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Joseph IB; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Milla ME; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA. marcos@samsaracap.com.

Publikováno v: Nature communications [Nat Commun] 2021 Aug 09; Vol. 12 (1), pp. 4785. Date of Electronic Publication: 2021 Aug 09.

IL-2 based cancer immunotherapies: an evolving paradigm.

Autor: Rokade, Sushama, Damani, Anita Mehta, Oft, Martin, Emmerich, Jan

Publikováno v: Frontiers in Immunology; 2024, p1-24, 24p

A novel dual mechanism-of-action bispecific PD-1-IL-2v armed by a "βγ-only" interleukin-2 variant.

Autor: Yongji Jiang, Chuyuan Chen, Yuan Liu, Rong Wang, Chuan Feng, Lili Cai, Shuang Chang, Lei Zhao

Publikováno v: Frontiers in Immunology; 2024, p1-12, 12p

Single cell transcriptome analyses reveal the roles of B cells in fructose-induced hypertension.

Autor: Cheong-Wun Kim, Sung Yong Joo, Boa Kim, Jee Young Kim, Sungmin Jang, Shiang-Jong Tzeng, Sang Jin Lee, Myunghoo Kim, Inkyeom Kim

Publikováno v: Frontiers in Immunology; 2023, p1-14, 14p

Evaluation of the clinical molecule anti-human-PD-L1/IL-15 KD033 in the human-PD-1/PD-L1-expressing murine model demonstrates PD-L1 targeting of IL-15 in vivo.

Autor: Martomo, Stella A., Patel, Jeegar

Publikováno v: Cancer Immunology, Immunotherapy; Jun2023, Vol. 72 Issue 6, p1941-1950, 10p