Zobrazeno 1 - 10
of 36
pro vyhledávání: '"San Hadži"'
Autor:
San Hadži, Zala Živič, Matic Kovačič, Uroš Zavrtanik, Sarah Haesaerts, Daniel Charlier, Janez Plavec, Alexander N. Volkov, Jurij Lah, Remy Loris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Disordered protein sequences can exhibit different binding modes, ranging from well-ordered folding-upon-binding to highly dynamic fuzzy binding. The primary function of the intrinsically disordered region of the antitoxin HigA2 from Vibrio
Externí odkaz:
https://doaj.org/article/06373e45cceb44e791bae82d031f10e3
Autor:
San Hadži, Zala Živič, Matic Kovačič, Uroš Zavrtanik, Sarah Haesaerts, Daniel Charlier, Janez Plavec, Alexander N. Volkov, Jurij Lah, Remy Loris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/15dc824587654d8cb1f120760493e947
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1150 (2022)
The structural polymorphism of G-quadruplex nucleic acids is an important factor in their recognition by proteins and small-molecule ligands. However, it is not clear why the binding of several ligands alters G-quadruplex topology. We addressed this
Externí odkaz:
https://doaj.org/article/ff3d1cb38c254d848e32b190bd0d5f65
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Protein interactions mediated by the intrinsically disordered proteins (IDPs) are generally associated with lower affinities compared to those between globular proteins. Here, we characterize the association between the intrinsically disordered HigA2
Externí odkaz:
https://doaj.org/article/d3091bdc08b04ed9b21671da03fa4f0f
Autor:
Ariel Talavera, Hedvig Tamman, Andres Ainelo, Albert Konijnenberg, San Hadži, Frank Sobott, Abel Garcia-Pino, Rita Hõrak, Remy Loris
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The Pseudomonas putida toxin GraT and antitoxin GraA form a type II toxin-antoxin module. Here the authors present the crystal structures of the GraA dimer, GraTA and GraA-DNA complexes and show that GraT contains a functionally important N-terminal
Externí odkaz:
https://doaj.org/article/2ca47fc86554403caf82746cade3eeed
Publikováno v:
Molecules, Vol 26, Iss 17, p 5188 (2021)
The recognition of specific DNA sequences in processes such as transcription is associated with a cooperative binding of proteins. Some transcription regulation mechanisms involve additional proteins that can influence the binding cooperativity by ac
Externí odkaz:
https://doaj.org/article/d23b3285b164493a85b1f8f0aa9d96ad
Autor:
Uroš Zavrtanik, San Hadži
Publikováno v:
Data in Brief, Vol 24, Iss , Pp - (2019)
A non-redundant data set of nanobody-antigen crystal structures is presented. The data set consists of a collection of cleaned pdb files which can be readily used as an input with most automatic analysis software. The accompanying data also include n
Externí odkaz:
https://doaj.org/article/b762e8af8eb84cdfb7d181feddbee34e
Publikováno v:
Journal of Medicinal Chemistry. 65:2623-2632
Monoclonal antibodies are the fastest growing class of therapeutics. However, aggregation limits their shelf life and can lead to adverse immune responses. Assessment and optimization of the long-term antibody stability are therefore key challenges i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fef81937b48b298d69adc6407c6cd8
https://doi.org/10.1021/acs.jmedchem.1c02010
https://doi.org/10.1021/acs.jmedchem.1c02010
Autor:
Maruša Prolič-Kalinšek, Alexander N. Volkov, San Hadži, Jeroen Van Dyck, Indra Bervoets, Daniel Charlier, Remy Loris
Publikováno v:
Acta crystallographica. Section D, Structural biology
YdaT is a functional equivalent of the CII repressor in certain lambdoid phages and prophages. YdaT from the cryptic prophage CP-933P in the genome of Escherichia coli O157:H7 is functional as a DNA-binding protein and recognizes a 5′-TTGATTN6AATCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6dbd176031b8b4c587c97ecc694d422
https://hdl.handle.net/10067/1951710151162165141
https://hdl.handle.net/10067/1951710151162165141
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