A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration.

Autor: San Gil R; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Pascovici D; Insight Stats, Croydon Park, NSW, Australia.; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde Sydney, NSW, Australia., Venturato J; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Brown-Wright H; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Mehta P; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Madrid San Martin L; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Wu J; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde Sydney, NSW, Australia., Luan W; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Chui YK; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Bademosi AT; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Swaminathan S; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Naidoo S; School of Biological Sciences, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Berning BA; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Wright AL; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Keating SS; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Curtis MA; Centre for Brain Research, University of Auckland, Auckland, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand., Faull RLM; Centre for Brain Research, University of Auckland, Auckland, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand., Lee JD; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia, Brisbane, QLD, Australia., Ngo ST; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia., Lee A; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Morsch M; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Chung RS; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Scotter E; School of Biological Sciences, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Lisowski L; Vector and Genome Engineering Facility, Children's Medical Research Institute, Westmead, NSW, Australia.; Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine - National Research Institute, Warsaw, Poland.; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Mirzaei M; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde Sydney, NSW, Australia., Walker AK; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. adam.walker@uq.edu.au.

Publikováno v: Nature communications [Nat Commun] 2024 Feb 19; Vol. 15 (1), pp. 1508. Date of Electronic Publication: 2024 Feb 19.

CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions.

Autor: Herrera-Pariente C; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain., Bonjoch L; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain., Muñoz J; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain., Fernàndez G; Hospital Sant Joan de Déu, CIBERER, 08950, Barcelona, Spain., Soares de Lima Y; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain., Mahmood R; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain., Cuatrecasas M; Pathology, Hospital Clínic, FRCB-IDIBAPS, CIBEREHD, 08036, Barcelona, Spain., Ocaña T; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain., Lopez-Prades S; Pathology, Hospital Clínic, FRCB-IDIBAPS, CIBEREHD, 08036, Barcelona, Spain., Llargués-Sistac G; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain., Domínguez-Rovira X; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain., Llach J; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain., Luzko I; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain., Díaz-Gay M; Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, UC San Diego, La Jolla, San Diego, CA, 92093, USA., Lazaro C; Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL, CIBERONC, 08908, Barcelona, Spain., Brunet J; Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL, CIBERONC, 08908, Barcelona, Spain.; Hereditary Cancer Program, Catalan Institute of Oncology, IDIBGI, 17190, Girona, Spain., Castillo-Manzano C; Hereditary Cancer Program, Catalan Institute of Oncology, 08916, Badalona, Spain., García-González MA; Instituto de Investigación Sanitaria Aragón, Instituto Aragonés de Ciencias de La Salud, CIBEREHD, 50009, Zaragoza, Spain., Lanas A; Instituto de Investigación Sanitaria Aragón, Instituto Aragonés de Ciencias de La Salud, CIBEREHD, 50009, Zaragoza, Spain.; Gastroenterology, Hospital Clínico Universitario de Zaragoza, Instituto de Investigación Sanitaria Aragón, Universidad de Zaragoza, CIBEREHD, 50009, Zaragoza, Spain., Carrillo M; Gastroenterology, Centro de Investigación Biomédica de Canarias (CIBICAN), Hospital Universitario de Canarias, Instituto Universitario de Tecnologías Biomédicas (ITB), Universidad de La Laguna, 38320, Santa Cruz de Tenerife, Spain., Hernández San Gil R; Department of Medical Oncology, Hospital Universitario de Canarias, 38320, Tenerife, Spain., Quintero E; Gastroenterology, Centro de Investigación Biomédica de Canarias (CIBICAN), Hospital Universitario de Canarias, Instituto Universitario de Tecnologías Biomédicas (ITB), Universidad de La Laguna, 38320, Santa Cruz de Tenerife, Spain., Sala N; Unit of Nutrition and Cancer, Translational Research Laboratory, Catalan Institute of Oncology (ICO) and Bellvitge Biomedical Research Institute (IDIBELL), 08908, Barcelona, Spain., Llort G; Medical Oncology, Parc Taulí University Hospital, 08208, Sabadell, Spain., Aguilera L; Gastroenterology, Vall d'Hebron Research Institute, 08035, Barcelona, Spain., Carot L; Gastroenterology, Hospital del Mar, 08003, Barcelona, Spain., Diez-Redondo P; Hospital Universitario Río Hortega, 47012, Valladolid, Spain., Jover R; Gastroenterology, Departamento de Medicina Clínica, Hospital General Universitario Dr. Balmis, Instituto de Investigación Sanitaria ISABIAL, Universidad Miguel Hernández, 03010, Alicante, Spain., Ramon Y Cajal T; Medical Oncology, Santa Creu I Sant Pau Hospital, 08041, Barcelona, Spain., Cubiella J; Gastroenterology, Complexo Hospitalario de Ourense, CIBEREHD, 32005, Ourense, Spain., Castells A; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain., Balaguer F; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain., Bujanda L; Department of Hepatology and Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Biodonostia Health Research Institute - Donostia University Hospital, Universidad del País Vasco (UPV/EHU), 20014, San Sebastián, Spain., Castellví-Bel S; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain., Moreira L; Gastroenterology, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), CIBEREHD, Universitat de Barcelona, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain. lmoreira@clinic.cat.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain. lmoreira@clinic.cat.

Publikováno v: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association [Gastric Cancer] 2024 Jul; Vol. 27 (4), pp. 747-759. Date of Electronic Publication: 2024 May 25.

Efficacy and safety of chemotherapy in young patients with advanced gastroesophageal adenocarcinoma: data from the Spanish AGAMENON-SEOM registry.

Autor: Pérez-Wert P; Medical Oncology Department, Hospital Universitario La Paz, CIBERONC CB16/12/00398, Paseo de La Castellana, 261, 28046, Madrid, Spain. pablopwert@gmail.com., Custodio A; Medical Oncology Department, Hospital Universitario La Paz, CIBERONC CB16/12/00398, Paseo de La Castellana, 261, 28046, Madrid, Spain., Jimenez-Fonseca P; Medical Oncology Department, Hospital Universitario Central de Asturias, ISPA, Oviedo, Spain., Carmona-Bayonas A; Hematology and Medical Oncology Department, Hospital Universitario Morales Meseguer, University of Murcia, IMIB, Murcia, Spain., Lecumberri A; Medical Oncology Department, Hospital Universitario de Navarra, Pamplona, Spain., Cacho Lavin D; Medical Oncology Department, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain., Losantos García I; Biostatistics Unit, IdiPAZ-Hospital Universitario La Paz, Madrid, Spain., Fernández Montes A; Medical Oncology Department, Complejo Hospitalario de Orense, Orense, Spain., Cano JM; Medical Oncology Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain., Limón ML; Medical Oncology Department, Hospital Universitario Virgen del Rocío, Seville, Spain., Hernández San Gil R; Medical Oncology Department, Hospital Universitario de Canarias, Tenerife, Spain., Diez M; Medical Oncology Department, Hospital Universitario Val d´Hebron, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain., Vidal Tocino R; Medical Oncology Department, Complejo Asistencial Universitario de Salamanca-IBSAL, Salamanca, Spain., Macías Declara I; Medical Oncology Department, Hospital Universitario Parc Tauli, Sabadell, Spain., Visa L; Medical Oncology Department, Hospital Universitario El Mar, Barcelona, Spain., Pimentel Cáceres P; Medical Oncology Department, Hospital General Universitario Santa Lucía, Cartagena, Spain., Gil Raga M; Medical Oncology Department, Hospital General Universitario de Valencia, Valencia, Spain., Martínez Moreno E; Medical Oncology Department, Hospital Universitario de Fuenlabrada, Madrid, Spain., Sauri T; Medical Oncology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain., Martín Richard M; Medical Oncology Department, Catalan Institute of Oncology, L'Hospitalet, Spain., Granja M; Medical Oncology Department, Hospital Universitario Clínico San Carlos, Madrid, Spain., Cerdà P; Medical Oncology Department, Hospital Universitario Santa Creu I Sant Pau, Barcelona, Spain., Gómez González L; Medical Oncology Department, Hospital General Universitario de Alicante, Alicante, Spain., Mérida-García A; Medical Oncology Department, Hospital Universitario de Zamora, Zamora, Spain., Ruiz Martín M; Medical Oncology Department, Hospital Universitario Río Carrión, Palencia, Spain., Gallego J; Medical Oncology Department, Hospital General Universitario of Elche, Elche, Spain.

Publikováno v: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association [Gastric Cancer] 2024 Jan; Vol. 27 (1), pp. 131-145. Date of Electronic Publication: 2023 Nov 15.

Impact of systemic cancer treatment on quality of life and mental well-being: a comparative analysis of patients with localized and advanced cancer.

Autor: Rodríguez-Gonzalez A; Department of Medical Oncology, Hospital Universitario Central of Asturias, ISPA, Faculty of Medicine, University of Oviedo, Avenida de Roma S/N, Oviedo, Asturias, Spain., Carmona-Bayonas A; Department of Medical Oncology, Hospital General Universitario Morales Meseguer, Murcia, Spain., Hernandez San Gil R; Department of Medical Oncology, Hospital Universitario de Canarias, Tenerife, Spain., Cruz-Castellanos P; Department of Medical Oncology, Hospital Universitario la Paz, Madrid, Spain., Antoñanzas-Basa M; Department of Medical Oncology, Hospital Universitario Clínico San Carlos, Madrid, Spain., Lorente-Estelles D; Department of Medical Oncology, Hospital Provincial de Castellón, Castellón, Spain., Corral MJ; Department of Clinical Psychology and Psychobiology, Faculty of Psychology, University of Barcelona, Barcelona, Spain., González-Moya M; Department of Medical Oncology. Hospital QuironSalud, Seville, Spain., Castillo-Trujillo OA; Department of Medical Oncology, Hospital Universitario Central of Asturias, ISPA, Faculty of Medicine, University of Oviedo, Avenida de Roma S/N, Oviedo, Asturias, Spain., Esteban E; Department of Medical Oncology, Hospital Universitario Central of Asturias, ISPA, Faculty of Medicine, University of Oviedo, Avenida de Roma S/N, Oviedo, Asturias, Spain., Jiménez-Fonseca P; Department of Medical Oncology, Hospital Universitario Central of Asturias, ISPA, Faculty of Medicine, University of Oviedo, Avenida de Roma S/N, Oviedo, Asturias, Spain. palucaji@hotmail.com., Calderon C; Department of Clinical Psychology and Psychobiology, Faculty of Psychology, University of Barcelona, Barcelona, Spain.

Publikováno v: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2023 Dec; Vol. 25 (12), pp. 3492-3500. Date of Electronic Publication: 2023 May 29.

Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD.

Autor: Luan W; Neurodegeneration Pathobiology Laboratory, Queensland Brain Institute, University of Queensland, St Lucia, QLD, Australia., Wright AL; Neurodegeneration Pathobiology Laboratory, Queensland Brain Institute, University of Queensland, St Lucia, QLD, Australia.; Centre for Motor Neuron Disease Research, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Brown-Wright H; Neurodegeneration Pathobiology Laboratory, Queensland Brain Institute, University of Queensland, St Lucia, QLD, Australia., Le S; Centre for Motor Neuron Disease Research, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., San Gil R; Neurodegeneration Pathobiology Laboratory, Queensland Brain Institute, University of Queensland, St Lucia, QLD, Australia., Madrid San Martin L; Neurodegeneration Pathobiology Laboratory, Queensland Brain Institute, University of Queensland, St Lucia, QLD, Australia., Ling K; Ionis Pharmaceuticals, Carlsbad, CA, 90201, USA., Jafar-Nejad P; Ionis Pharmaceuticals, Carlsbad, CA, 90201, USA., Rigo F; Ionis Pharmaceuticals, Carlsbad, CA, 90201, USA., Walker AK; Neurodegeneration Pathobiology Laboratory, Queensland Brain Institute, University of Queensland, St Lucia, QLD, Australia. adam.walker@uq.edu.au.; Centre for Motor Neuron Disease Research, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia. adam.walker@uq.edu.au.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2023 Jun; Vol. 28 (6), pp. 2445-2461. Date of Electronic Publication: 2023 Apr 03.