Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Samyuktha Guttha"'
Autor:
Jacob K. Sterling, Bailey Baumann, Sierra Foshe, Andrew Voigt, Samyuktha Guttha, Ahab Alnemri, Sam J. McCright, Mingyao Li, Randy J. Zauhar, Sandra R. Montezuma, Rebecca J. Kapphahn, Venkata R.M. Chavali, David A. Hill, Deborah A. Ferrington, Dwight Stambolian, Robert F. Mullins, David Merrick, Joshua L. Dunaief
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110942- (2022)
Summary: Age-related macular degeneration (AMD), the leading cause of irreversible blindness among Americans over 50, is characterized by dysfunction and death of retinal pigment epithelial (RPE) cells. The RPE accumulates iron in AMD, and iron overl
Externí odkaz:
https://doaj.org/article/a701cd56ed6f48bc9d2e45ba3c34f5f4
Autor:
Jacob K. Sterling, Modupe O. Adetunji, Samyuktha Guttha, Albert R. Bargoud, Katherine E. Uyhazi, Ahmara G. Ross, Joshua L. Dunaief, Qi N. Cui
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108271- (2020)
Summary: Glaucoma is the leading cause of irreversible blindness and is characterized by the death of retinal ganglion cells (RGCs). Recent studies have implicated pro-inflammatory microglia, macrophages, and A1 astrocytes in the pathogenesis of neur
Externí odkaz:
https://doaj.org/article/75de906bdc0e4cc7bbdb65b3f0a09636
Autor:
Steven Carrubba, Alexi Geevarghese, Elena Solli, Samyuktha Guttha, Jeffrey Sims, Laurence Sperber, Shane Meehan, Ann Ostrovsky
Publikováno v:
The Lancet Infectious Diseases. 23:e190-e197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad342894f034b8e70b9680b89b5e8dad
https://doi.org/10.1016/s1473-3099(22)00869-6
https://doi.org/10.1016/s1473-3099(22)00869-6
Autor:
Kevin R. Zhang, Bailey Baumann, Ying Song, Jacob Sterling, Elizabeth A. Erler, Samyuktha Guttha, Zbynek Kozmik, Joshua L. Dunaief
Publikováno v:
Exp Eye Res
Iron accumulation has been implicated in degenerative retinal diseases. It can catalyze the production of damaging reactive oxygen species. Previous work has demonstrated iron accumulation in multiple retinal diseases, including age-related macular d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f93860c0ab44cd6a9616f9b877476c8
https://europepmc.org/articles/PMC9050911/
https://europepmc.org/articles/PMC9050911/
Autor:
Ahmara G. Ross, Katherine E. Uyhazi, Samyuktha Guttha, Albert R. Bargoud, Modupe O Adetunji, Qi N. Cui, Joshua L. Dunaief, Jacob Sterling
SUMMARYGlaucoma is the leading cause of irreversible blindness worldwide and is characterized by the death of retinal ganglion cells. Reduction of intraocular pressure (IOP) is the only therapeutic mechanism available to slow disease progression. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ba1bcf8575da8fdd897866a8541a7c2
https://doi.org/10.1101/2020.06.18.146720
https://doi.org/10.1101/2020.06.18.146720
Autor:
Samyuktha Guttha, Ahmara G. Ross, Albert Bargoud, Joshua L. Dunaief, Katherine E. Uyhazi, Qi N. Cui, Jacob Sterling, Modupe O Adetunji
Publikováno v:
Cell reports
Cell Reports, Vol 33, Iss 5, Pp 108271-(2020)
Cell Reports, Vol 33, Iss 5, Pp 108271-(2020)
SUMMARY Glaucoma is the leading cause of irreversible blindness and is characterized by the death of retinal ganglion cells (RGCs). Recent studies have implicated pro-inflammatory microglia, macrophages, and A1 astrocytes in the pathogenesis of neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefbbe4473e0fef67bbd9ae0a48e5aca
https://pubmed.ncbi.nlm.nih.gov/33147455
https://pubmed.ncbi.nlm.nih.gov/33147455
Autor:
Jacob K. Sterling, Tae-In Kam, Samyuktha Guttha, Hyejin Park, Bailey Baumann, Amir A. Mehrabani-Tabari, Hannah Schultz, Brandon Anderson, Ahab Alnemri, Shih-Ching Chou, Juan C. Troncoso, Valina L. Dawson, Ted M. Dawson, Joshua L. Dunaief
Publikováno v:
Cell Reports. 38:110358
α-synuclein (α-syn) aggregation and accumulation drive neurodegeneration in Parkinson's disease (PD). The substantia nigra of patients with PD contains excess iron, yet the underlying mechanism accounting for this iron accumulation is unclear. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ec1dbfc491f73f25bcdcdbb2e1bc2d
https://doi.org/10.1016/j.celrep.2022.110358
https://doi.org/10.1016/j.celrep.2022.110358
Autor:
Joshua L. Dunaief, Delu Song, Majda Hadziahmetovic, Samyuktha Guttha, Ying Song, Jacob Sterling
Publikováno v:
Experimental Eye Research. 155:15-23
Intracellular retinal iron accumulation has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of irreversible blindness among individuals over the age of 50. Ceruloplasmin/hephaestin double knockout mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f1feee25a443e3e88bd361275204ca
https://doi.org/10.1016/j.exer.2016.12.008
https://doi.org/10.1016/j.exer.2016.12.008