Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Samy O. Meroueh"'
Autor:
Khuchtumur Bum-Erdene, I-Ju Yeh, Giovanni Gonzalez-Gutierrez, Mona K. Ghozayel, Karen Pollok, Samy O. Meroueh
Publikováno v:
Journal of Medicinal Chemistry. 66:266-284
Transcriptional enhanced associate domains (TEADs) are transcription factors that bind to cotranscriptional activators like the yes-associated protein (YAP) or its paralog transcriptional coactivator with a PDZ-binding motif (TAZ). TEAD·YAP/TAZ targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64dc37be5d341eda267e8b35aa264fbf
https://doi.org/10.1021/acs.jmedchem.2c01189
https://doi.org/10.1021/acs.jmedchem.2c01189
Publikováno v:
ACS Med Chem Lett
[Image: see text] There is substantial interest in the development of small molecules that inhibit the tight and highly challenging protein–protein interaction between the glycophosphatidylinositol (GPI)-anchored cell surface receptor uPAR and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd108d6035896a06db2971cd65837e9
https://doi.org/10.1021/acsmedchemlett.0c00422
https://doi.org/10.1021/acsmedchemlett.0c00422
Autor:
Clark D. Wells, Timothy W. Corson, Melissa L. Fishel, Barbara J. Bailey, Karen E. Pollok, Donghui Zhou, Jun Wan, David Xu, Jonathan A. Lee, Samy O. Meroueh, Sheng Liu, Uma K. Aryal, Khuchtumur Bum-Erdene, Kamakshi Sishtla
Publikováno v:
ACS Chem Biol
Like most solid tumors, glioblastoma multiforme (GBM) harbors multiple overexpressed and mutated genes that affect several signaling pathways. Suppressing tumor growth of solid tumors like GBM without toxicity may be achieved by small molecules that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0f17bca988690af16c04342eda0321
https://doi.org/10.1021/acschembio.0c00078
https://doi.org/10.1021/acschembio.0c00078
Publikováno v:
ChemMedChem
Ral GTPases belong to the RAS superfamily, and they are directly activated by K-RAS. The RalGEF pathway is one of the three major K-RAS signaling pathways. Ral GTPases do not possess a cysteine nucleophile to develop a covalent inhibitor following th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936d6e09d00196e6988a8fbcff7e1b15
https://doi.org/10.1002/cmdc.202100750
https://doi.org/10.1002/cmdc.202100750
Autor:
Mona K. Ghozayel, Khuchtumur Bum-Erdene, Baocheng Yang, Samy O. Meroueh, David Xu, Paul A. Clemons, Yubing Si
Publikováno v:
ChemMedChem. 14:119-131
There is growing interest in the use of structure-based virtual screening to identify small molecules that inhibit challenging protein-protein interactions (PPIs). In this study, we investigated how effectively chemical library members docked at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0500630ce541662802d87b0769f356
https://doi.org/10.1002/cmdc.201800537
https://doi.org/10.1002/cmdc.201800537
Autor:
Tao Yu, George E. Sandusky, Xinna Zhang, Yifan Sun, Ka Man So, Guang Ji, Amber L. Mosley, Han-Chen Xu, Yunlong Liu, Samy O. Meroueh, Lu Zhang, Xiaoming He, Changlin Wan, Zhuolong Zhou, Cheng Huang, Xiongbin Lu, Chi Zhang, Yujing Li, Yuanzhang Fang, Degang Liu, Aruna B. Wijeratne, Michael Frieden, Kevin Van der Jeught
Publikováno v:
J Clin Invest
One of the primary mechanisms of tumor cell immune evasion is the loss of antigenicity, which arises due to lack of immunogenic tumor antigens as well as dysregulation of the antigen processing machinery. In a screen for small-molecule compounds from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b10d5692d47ca33fb6607f39a047791
https://pubmed.ncbi.nlm.nih.gov/33830945
https://pubmed.ncbi.nlm.nih.gov/33830945
Autor:
Khuchtumur Bum-Erdene, Samy O. Meroueh, Degang Liu, David Xu, Mona K. Ghozayel, Giovanni Gonzalez-Gutierrez
Publikováno v:
Proc Natl Acad Sci U S A
Ral (Ras-like) GTPases are directly activated by oncogenic Ras GTPases. Mutant K-Ras (G12C) has enabled the development of covalent K-Ras inhibitors currently in clinical trials. However, Ral, and the overwhelming majority of mutant oncogenic K-Ras,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b25cef295fde188727d9ad8df9c9e3
https://pubmed.ncbi.nlm.nih.gov/32179690
https://pubmed.ncbi.nlm.nih.gov/32179690
Autor:
Timothy W. Corson, Sardar Pasha Sheik Pran Babu, Samy O. Meroueh, Sayak K. Mitter, Seung-Yong Seo, Wei Sun, Rania S. Sulaiman, Bit Lee, Xiaoping Qi, Yubing Si, Bomina Park, Xiang Fei, Rakshin Kharwadkar, Michael E. Boulton
Publikováno v:
ACS Chemical Biology. 13:45-52
The standard-of-care therapeutics for the treatment of ocular neovascular diseases like wet age-related macular degeneration (AMD) are biologics targeting vascular endothelial growth factor signaling. There are currently no FDA approved small molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69fce039098c45f199bdd98d12325a2
https://doi.org/10.1021/acschembio.7b00854
https://doi.org/10.1021/acschembio.7b00854
Publikováno v:
Journal of Chemical Information and Modeling. 57:2250-2272
The binding affinity of a protein–protein interaction is concentrated at amino acids known as hot spots. It has been suggested that small molecules disrupt protein–protein interactions by either (i) engaging receptor protein hot spots or (ii) mim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c79bf6dabad68ea3813c9c0055a628d9
https://doi.org/10.1021/acs.jcim.7b00181
https://doi.org/10.1021/acs.jcim.7b00181
Autor:
Donghui Zhou, Kay F. Macleod, Andy Hudmon, Degang Liu, David Xu, Samy O. Meroueh, Maya Z. Springer
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2995-3005
Triple-negative breast cancers (TNBCs) lack the signature targets of other breast tumors, such as HER2, estrogen receptor, and progesterone receptor. These aggressive basal-like tumors are driven by a complex array of signaling pathways that are acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd90a5149d5b711e9286b13b6fbfcba
https://doi.org/10.1016/j.bmc.2017.03.048
https://doi.org/10.1016/j.bmc.2017.03.048