Výsledky vyhledávání - "Samy M Eleawa"

Akademický článek

Camel milk protein hydrosylate alleviates hepatic steatosis and hypertension in high fructose-fed rats

Autor: Mohammad A. Alshuniaber, Ghedeir M. Alshammari, Samy M. Eleawa, Abu ElGasim A. Yagoub, Abdullrahman S. Al-Khalifah, Maha H. Alhussain, Laila Naif Al-Harbi, Mohammed Abdo Yahya

Publikováno v: Pharmaceutical Biology, Vol 60, Iss 1, Pp 1137-1147 (2022)

Context Camel milk is used in traditional medicine to treat diabetes mellitus hypertension and other metabolic disorders.Objective This study evaluated the antisteatotic and antihypertensive effects of camel milk protein hydrolysate (CMH) in high fru

Externí odkaz: https://doaj.org/article/eabc9b685734460f8d79767ca3056073

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Akademický článek

Fish oil protects against corn oil-induced cardiac insulin resistance and left ventricular dysfunction in rats via upregulation of PPAR-β/γ and inhibition of diacylglycerol/PCK axis activation

Autor: Refaat A. Eid, Mubarak Al-Shraim, Samy M. Eleawa, Mohamed Samir Ahmed Zaki, Attalla Farag El-kott, Muhammad Alaa Eldeen, Mahmoud A. Alkhateeb, Mohammed Alassiri, Hussain Alderah

Publikováno v: Journal of Functional Foods, Vol 56, Iss , Pp 342-352 (2019)

This study investigated the effects corn oil (CO) and different ratios of corn oil plus fish oil (FO) on insulin signaling in rat's heart. Adult male rats were fed low (LFD) or isocaloric high-fat diets (HFDs) of CO alone or CO + FO (ratios of 9:1 or

Externí odkaz: https://doaj.org/article/95a3ce40069d48fcbafdf288850badaf

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Exendin-4 Protects Against Myocardial Ischemia-Reperfusion Injury by Upregulation of SIRT1 and SIRT3 and Activation of AMPK

Autor: Mashael Mohammed Bin-Meferij, Samah A. Alharbi, Mubarak Al-Shraim, Muhammad Alaa Eldeen, Hussain Aldera, Refaat A. Eid, Mahmoud A. Alkhateeb, Fahmy El-Sayed, Attalla F. El-kott, Mohamed Samir Ahmed Zaki, Mohammad A. Khalil, Samy M Eleawa

Publikováno v: Journal of Cardiovascular Translational Research. 14:619-635

This study evaluated if the cardioprotective effect of Exendin-4 against ischemia/reperfusion (I/R) injury in male rats involves modulation of AMPK and sirtuins. Adult male rats were divided into sham, sham + Exendin-4, I/R, I/R + Exendin-4, and I/R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d144eee75bda48ead6978bcd5195bf9b
https://doi.org/10.1007/s12265-020-09984-5

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Exendin-4 Ameliorates Cardiac Remodeling in Experimentally Induced Myocardial Infarction in Rats by Inhibiting PARP1/NF-κB Axis in A SIRT1-Dependent Mechanism

Autor: Samy M Eleawa, Mohamed Samir Ahmed Zaki, Fahmy El-Sayed, Abd Al‐Rahman Salem Al‐Shudiefat, Attalla F. El-kott, Hussain Aldera, Refaat A. Eid, Muhammad Alaa Eldeen, Samah A. Alharbi

Publikováno v: Cardiovascular Toxicology. 20:401-418

Sirt1 is a potent inhibitor of both poly(ADP-ribose) polymerases1 (PARP1) and NF-kB. This study investigated the cardioprotective effect of exendin-4 on cardiac function and remodeling in rats after an expreimentally-induced myocardial infarction (MI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c0f3e0057602a9e665bf81e38ec40e
https://doi.org/10.1007/s12012-020-09567-5

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Melatonin attenuates cerebral hypoperfusion-induced hippocampal damage and memory deficits in rats by suppressing TRPM7 channels

Autor: Hussain Al Dera, Mohammed Alassiri, Reem Al Kahtani, Samy M. Eleawa, Mohammad K. AlMulla, Abdulhakeem Alamri

Publikováno v: Saudi journal of biological sciences. 29(4)

This study was conducted to examine if modulating transporters like transient receptor potential cation channels, subfamily M, member 7 (TRPM7) underlies the hippocampal neuroprotection afforded by melatonin (Mel) in rats exposed to cerebral hypoperf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44f6f2a06328ff6ac3023b58f4ce446
https://pubmed.ncbi.nlm.nih.gov/35531206

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Kaempferol Protects Against Cadmium Chloride-Induced Memory Loss and Hippocampal Apoptosis by Increased Intracellular Glutathione Stores and Activation of PTEN/AMPK Induced Inhibition of Akt/mTOR Signaling

Autor: Samy M Eleawa, Mashael Mohammed Bin-Meferij, Majed M. Alshehri, Attalla F. El-kott

Publikováno v: Neurochemical Research. 45:295-309

This study investigated the protective effect of Kaempferol against CdCl2-induced hippocampal damage and memory deficit in rats and investigated if such effects involve modulating the activity of AMPK/PTEN/Akt/mTOR axis. Adult male rats (n = 12/group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2dfe2fc0c83870478ec25f23143a55b
https://doi.org/10.1007/s11064-019-02911-4

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Melatonin Improves Memory Deficits in Rats with Cerebral Hypoperfusion, Possibly, Through Decreasing the Expression of Small-Conductance Ca2+-Activated K+ Channels

Autor: Abdelaziz M. Hussein, Sultan Alqahtani, Samy M Eleawa, Hussein F. Sakr, Mohammad A. Khalil, Mohammed Alassiri, Hussain Al Dera, Mahmoud A. Alkhateeb, Mohammad Dallak

Publikováno v: Neurochemical Research. 44:1851-1868

This study investigated the expression pattern, regulation of expression, and the role of hippocampal small-conductance Ca2+-activated K+ (SK) channels in memory deficits after cerebral hypoperfusion (CHP) with or without melatonin treatment, in rats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::046106d2bb10dee53dc72613d338da1d
https://doi.org/10.1007/s11064-019-02820-6

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Subacute ghrelin administration inhibits apoptosis and improves ultrastructural abnormalities in remote myocardium post-myocardial infarction

Autor: Fahaid Al-Hashem, Mahmoud A. Alkhateeb, Attalla F. El-kott, Refaat A. Eid, Mubarak Al-Shraim, Mohamed Samir Ahmed Zaki, Hoja Ibrahim, Hussain Aldera, Muhammad Alaa Eldeen, Samy M Eleawa

Publikováno v: Biomedicine & Pharmacotherapy. 101:920-928

This study investigated the effect of ghrelin on cardiomyocytes function, apoptosis and ultra-structural alterations of remote myocardium of the left ventricle (LV) of rats, 21 days post myocardial infarction (MI). Rats were divided into 4 groups as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617d0f4795884882dc78c3258b99f762
https://doi.org/10.1016/j.biopha.2018.03.010

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Ghrelin prevents cardiac cell apoptosis during cardiac remodelling post experimentally induced myocardial infarction in rats via activation of Raf-MEK1/2-ERK1/2 signalling

Autor: Fahaid Al-Hashem, Samy M Eleawa, Ismaeel Bin-Jaliah, Mahmoud A. Alkhateeb, Khalid A. Shatoor, Refaat A. Eid, Abdullah S. Shatoor, Mohamed Samir Ahmed Zaki, Mubarak Al-Shraim, Attalla F. El-kott

Publikováno v: Archives of Physiology and Biochemistry. 125:93-103

Mechanisms by which ghrelin affords its cardioprotection in mammals remained unclear.To examine if ghrelin confers cardio-protection during cardiac remodelling post-MI by modulating the RAF-1-MEK1/2-ERK1/2 signalling pathway.Rats were divided into co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14a4e0fc539117327847bf2548a4005
https://doi.org/10.1080/13813455.2018.1437751

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