Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Samy L. Habib"'
Autor:
Pallavi Kompella, Guliang Wang, Russell E. Durrett, Yanhao Lai, Celeste Marin, Yuan Liu, Samy L. Habib, John DiGiovanni, Karen M. Vasquez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Obesity is associated with increased cancer risk, yet the underlying mechanisms remain elusive. Obesity-associated cancers involve disruptions in metabolic and cellular pathways, which can lead to genomic instability. Repetitive DNA sequence
Externí odkaz:
https://doaj.org/article/363ca44e435d4b4689a49fce09619af1
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 9, Pp 730-743 (2021)
Abstract Epithelial–mesenchymal transition (EMT) plays an important role in tissue fibrosis following chronic exposure to hyperglycemia. This study investigates the role of chronic diabetes in regulating tuberin/snail/AMPK to enhance EMT and increa
Externí odkaz:
https://doaj.org/article/619599559b9440fdb487fe0187db292f
Autor:
Dan He, Hongguang Wu, Jinnan Xiang, Xinsen Ruan, Peike Peng, Yuanyuan Ruan, Ye-Guang Chen, Yibin Wang, Qiang Yu, Hongbing Zhang, Samy L. Habib, Ronald A. De Pinho, Huijuan Liu, Baojie Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Intestinal aging is associated with declines in structure and absorption of nutrients. Here, the authors show that aging related intestinal decline is mediated by activation of the mTORC1-p38MAPK-p53 pathway in intestinal stem cells and can be amelio
Externí odkaz:
https://doaj.org/article/2b693f1be87a4d81b68d6deb696ecba7
Autor:
Ke Li, Hongguang Wu, Ao Wang, Jean Charron, Yuji Mishina, Samy L. Habib, Huijuan Liu, Baojie Li
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109069- (2021)
Summary: mTOR, the sensor of nutrients and growth factors, has important roles in tissue homeostasis and tumorigenesis. However, how mTOR controls gastric epithelial cell turnover and gastric cancer development, a leading malignancy, remains poorly u
Externí odkaz:
https://doaj.org/article/b6ea9c7aabb041719f8031128fb06a17
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 557 (2022)
Innate immunity is critical for immediate recognition and elimination of invading pathogens or defense against cancer cell growth. Dysregulation of innate immune systems is associated with the pathogenesis of different types of inflammatory diseases,
Externí odkaz:
https://doaj.org/article/b4732b6fa8ed4c7fba2d38624bb25207
Publikováno v:
Molecular Oncology, Vol 12, Iss 11, Pp 1917-1934 (2018)
Loss of Von Hippel‐Lindau in renal carcinoma cells results in upregulation of the activity of hypoxia‐inducible factor (HIF‐α), a major transcription factor involved in kidney cancer. Rapamycin as mammalian target of rapamycin inhibitor and 5
Externí odkaz:
https://doaj.org/article/494175f547704be3864c9bb5e0297b38
Autor:
Hongguang Wu, Zhixiang Wu, Ping Li, Qian Cong, Rongrong Chen, Wenrui Xu, Soma Biswas, Huijuan Liu, Xuechun Xia, Shanshan Li, Weiwei Hu, Zhenlin Zhang, Samy L. Habib, Lingli Zhang, Jun Zou, Hongbing Zhang, Weihong Zhang, Baojie Li
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1600-1616 (2017)
The bone size and quality, acquired during adolescent growth under the influence of anabolic hormones, growth factors, and nutrients, determine the height and bone stability and forecast osteoporosis risks in late life. Yet bone size and quality cont
Externí odkaz:
https://doaj.org/article/f936622d4824437ab6da48b54dc235d0
Data from mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK
Autor:
Baojie Li, Huijuan Liu, Samy L. Habib, Bijaya K. Nayak, Yibin Wang, Jean Charron, Xin Zhou, Md Shafiquzzaman, Soma Biswas, Dan He, Hongguang Wu
Renal cell carcinoma (RCC) mainly originates from renal proximal tubules. Intriguingly, disruption of genes frequently mutated in human RCC samples thus far has only generated RCC originated from other renal tubule parts in mouse models. This hampers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37e0a9ade1c4fe70e3d9a790b27a1d72
https://doi.org/10.1158/0008-5472.c.6513277.v1
https://doi.org/10.1158/0008-5472.c.6513277.v1
Autor:
Robert H. Weiss, Julie Sutcliffe, Abhijit J. Chaudhari, Sitai Liang, Benjamin Stewart, Josephine Trott, Samy L. Habib, Omran Abu Aboud
Further representative sections of normal right kidney (RK) and tumor tissues were subjected to immunohistochemical analysis for NRF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57104a10171fca0553fb17d18d55ffc5
https://doi.org/10.1158/0008-5472.22415154.v1
https://doi.org/10.1158/0008-5472.22415154.v1
Autor:
Robert H. Weiss, Julie Sutcliffe, Abhijit J. Chaudhari, Sitai Liang, Benjamin Stewart, Josephine Trott, Samy L. Habib, Omran Abu Aboud
Many cancers appear to activate intrinsic antioxidant systems as a means to counteract oxidative stress. Some cancers, such as clear cell renal cell carcinoma (ccRCC), require exogenous glutamine for growth and exhibit reprogrammed glutamine metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a228d4cea959d38b45c0ec29ba3beb53
https://doi.org/10.1158/0008-5472.c.6509184
https://doi.org/10.1158/0008-5472.c.6509184