Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Samy Kefalopoulou"'
Autor:
Ryan J. Geusz, Allen Wang, Dieter K. Lam, Nicholas K. Vinckier, Konstantinos-Dionysios Alysandratos, David A. Roberts, Jinzhao Wang, Samy Kefalopoulou, Araceli Ramirez, Yunjiang Qiu, Joshua Chiou, Kyle J. Gaulton, Bing Ren, Darrell N. Kotton, Maike Sander
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Enhancers for endodermal organs are primed at the chromatin level prior to lineage induction by FOXA pioneer transcription factors; how pervasive this is, is not well known. Here the authors show that only a small subset of organ-specific enhancers a
Externí odkaz:
https://doaj.org/article/a8ff109def3c49e6a1431185b2073726
Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
Autor:
Ryan J Geusz, Allen Wang, Joshua Chiou, Joseph J Lancman, Nichole Wetton, Samy Kefalopoulou, Jinzhao Wang, Yunjiang Qiu, Jian Yan, Anthony Aylward, Bing Ren, P Duc Si Dong, Kyle J Gaulton, Maike Sander
Publikováno v:
eLife, Vol 10 (2021)
Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as pancreatic islets. Here, we investigated contributions of regulatory programs active during pancreatic development to T2D ri
Externí odkaz:
https://doaj.org/article/ae2ad6bb2f8440508324b4fcde2ff75c
Publikováno v:
Cells, Vol 8, Iss 3, p 271 (2019)
The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. Genomic regions contacting the NL are lamina associated domains (LAD
Externí odkaz:
https://doaj.org/article/4f5df0dcb3874419afedbbd6fcaa4f73
Autor:
Dieter K Lam, Konstantinos-Dionysios Alysandratos, Samy Kefalopoulou, Joshua Chiou, Darrell N. Kotton, Kyle J Gaulton, Nicholas K Vinckier, Allen Y. Wang, Bing Ren, Jinzhao Wang, Yunjiang Qiu, Araceli Ramirez, Maike Sander, David A. Roberts, Ryan J Geusz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications
Nature communications, vol 12, iss 1
FOXA pioneer transcription factors (TFs) associate with primed enhancers in endodermal organ precursors. Using a human stem cell model of pancreas differentiation, we here discover that only a subset of pancreatic enhancers is FOXA-primed, whereas th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c707515c982f95358c386edd746aa207
https://doaj.org/article/a8ff109def3c49e6a1431185b2073726
https://doaj.org/article/a8ff109def3c49e6a1431185b2073726
Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
Autor:
Yunjiang Qiu, Bing Ren, P. Duc Si Dong, Joshua Chiou, Allen Wang, Nichole Wetton, Joseph J. Lancman, Maike Sander, Anthony Aylward, Samy Kefalopoulou, Jinzhao Wang, Jian Yan, Ryan J Geusz, Kyle J. Gaulton
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as pancreatic islets. Here, we investigated contributions of regulatory programs active during pancreatic development to T2D ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c8c4dda20ab0e4735b55a8c63b6e8b
http://edoc.mdc-berlin.de/22523/1/22523oa.pdf
http://edoc.mdc-berlin.de/22523/1/22523oa.pdf
Autor:
Anthony Aylward, Joseph J. Lancman, Nichole Wetton, Ryan J Geusz, Allen Wang, Jian Yan, Kyle J. Gaulton, Joshua Chiou, Jinzhao Wang, Maike Sander, Yunjiang Qiu, Bing Ren, Samy Kefalopoulou, P. Duc Si Dong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71404a476713210243eeba42f2ac1d42
https://doi.org/10.7554/elife.59067.sa2
https://doi.org/10.7554/elife.59067.sa2
Autor:
Darrell N. Kotton, Yunjiang Qiu, Allen Wang, Ryan J Geusz, Jinzhao Wang, Bing Ren, Konstantinos-Dionysios Alysandratos, Samy Kefalopoulou, Nicholas Vinckier, Maike Sander, David A. Roberts, Joshua Chiou, Dieter K. Lam, Kyle J. Gaulton
SUMMARYFOXA pioneer transcription factors (TFs) displace nucleosomes and prime chromatin across enhancers of different endodermal organs in multipotent precursors before lineage induction. Here, we examined patterns and mechanisms of FOXA target site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16bba39dbe1d4eb46a7e3ab83241bfbc
https://doi.org/10.1101/2020.08.28.263020
https://doi.org/10.1101/2020.08.28.263020
Publikováno v:
Cells
Cells, Vol 8, Iss 3, p 271 (2019)
Cells, 8(3). Multidisciplinary Digital Publishing Institute (MDPI)
Cells, Vol 8, Iss 3, p 271 (2019)
Cells, 8(3). Multidisciplinary Digital Publishing Institute (MDPI)
The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. Genomic regions contacting the NL are lamina associated domains (LAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89edd3a042726f8d3685ef79672f6436
https://pubmed.ncbi.nlm.nih.gov/30901978
https://pubmed.ncbi.nlm.nih.gov/30901978