Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Samy, Omri"'
Autor:
Catherine Argyriou, Anna Polosa, Ji Yun Song, Samy Omri, Bradford Steele, Bruno Cécyre, Devin S. McDougald, Erminia Di Pietro, Jean-François Bouchard, Jean Bennett, Joseph G. Hacia, Pierre Lachapelle, Nancy E. Braverman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 225-240 (2021)
Patients with Zellweger spectrum disorder (ZSD) commonly present with vision loss due to mutations in PEX genes required for peroxisome assembly and function. Here, we evaluate PEX1 retinal gene augmentation therapy in a mouse model of mild ZSD beari
Externí odkaz:
https://doaj.org/article/8cbf07d636cf46afa1661d18efa2eb4c
Autor:
Rabah Dabouz, Colin W. H. Cheng, Pénélope Abram, Samy Omri, Gael Cagnone, Khushnouma Virah Sawmy, Jean-Sébastien Joyal, Michel Desjarlais, David Olson, Alexander G. Weil, William Lubell, José Carlos Rivera, Sylvain Chemtob
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-19 (2020)
Abstract Background Inflammation and particularly interleukin-1β (IL-1β), a pro-inflammatory cytokine highly secreted by activated immune cells during early AMD pathological events, contribute significantly to retinal neurodegeneration. Here, we id
Externí odkaz:
https://doaj.org/article/506aa30b38074c1d9d6c7c66eb9f544b
Autor:
Melanie Sanchez, David Hamel, Emmanuel Bajon, François Duhamel, Vikrant K. Bhosle, Tang Zhu, Jose Carlos Rivera, Rabah Dabouz, Mathieu Nadeau-Vallée, Nicholas Sitaras, David-Étienne Tremblay, Samy Omri, Tiffany Habelrih, Raphael Rouget, Xin Hou, Fernand Gobeil, Jean-Sébastien Joyal, Przemyslaw Sapieha, Grant Mitchell, Alfredo Ribeiro-Da-Silva, Mohammad Ali Mohammad Nezhady, Sylvain Chemtob
Publikováno v:
Cells, Vol 11, Iss 14, p 2185 (2022)
The GPCR SUCNR1/GPR91 exerts proangiogenesis upon stimulation with the Krebs cycle metabolite succinate. GPCR signaling depends on the surrounding environment and intracellular localization through location bias. Here, we show by microscopy and by ce
Externí odkaz:
https://doaj.org/article/08718907106b4199a8f209beb94c4878
Autor:
Michel Desjarlais, Pakiza Ruknudin, Maëlle Wirth, Isabelle Lahaie, Rabah Dabouz, José Carlos Rivera, Tiffany Habelrih, Samy Omri, Pierre Hardy, Alain Rivard, Sylvain Chemtob
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Background and AimInsufficient post-ischemic neovascularization is an initial key step in the pathogenesis of Oxygen-Induced Retinopathy (OIR). During neovascularization, pro-angiogenic cells (PACs) are mobilized from the bone marrow and integrate in
Externí odkaz:
https://doaj.org/article/8897c27c0d2f4502b53fdb07ee39e51b
Autor:
Baraa Noueihed, José Carlos Rivera, Rabah Dabouz, Pénélope Abram, Samy Omri, Isabelle Lahaie, Sylvain Chemtob
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Ischemic retinopathies (IRs), such as retinopathy of prematurity and diabetic retinopathy, are characterized by an initial phase of microvascular degeneration that results in retinal ischemia, followed by exaggerated pathologic neovascularization (NV
Externí odkaz:
https://doaj.org/article/618cc221bcd24071a2b85b2557f3586c
Autor:
Diane N. Sayah, Tianwei E. Zhou, Samy Omri, Javier Mazzaferri, Christiane Quiniou, Maëlle Wirth, France Côté, Rabah Dabouz, Michel Desjarlais, Santiago Costantino, Sylvain Chemtob
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Retinopathy of prematurity (ROP) is the leading cause of blindness in neonates. Inflammation, in particular interleukin-1β (IL-1β), is increased in early stages of the disorder, and contributes to inner and outer retinal vasoobliteration in the oxy
Externí odkaz:
https://doaj.org/article/517d3ff6c4aa43ef846cb4aa5a9b4ca5
Autor:
Michel Desjarlais, Maëlle Wirth, José Carlos Rivera, Isabelle Lahaie, Rabah Dabouz, Samy Omri, Pakiza Ruknudin, Celine Borras, Sylvain Chemtob
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Background and AimsVascular degeneration is a hallmark in the pathogenesis of oxygen-induced retinopathy (OIR). Dysregulation of microRNAs (miRNAs), key regulators of genes expressions, has been implicated in the regulation of ocular angiogenesis. Ho
Externí odkaz:
https://doaj.org/article/a3af8494e69948a9855d7f4b472db4b9
Autor:
Michel Desjarlais, Jose Carlos Rivera, Isabelle Lahaie, Gaël Cagnone, Maëlle Wirt, Samy Omri, Sylvain Chemtob
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218282 (2019)
BackgroundIschemic retinopathies (IRs) are leading causes of visual impairment. They are characterized by an initial phase of microvascular degeneration and a second phase of aberrant pre-retinal neovascularization (NV). microRNAs (miRNAs) regulate g
Externí odkaz:
https://doaj.org/article/623050ef1c944734bd2b321a91375b84
Autor:
Jean-François Bouchard, Pierre Lachapelle, Samy Omri, Nancy Braverman, Devin S. McDougald, Ji Yun Song, Erminia Di Pietro, Bruno Cécyre, Catherine Argyriou, Anna Polosa, Joseph G. Hacia, Jean Bennett, Bradford H. Steele
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 225-240 (2021)
Patients with Zellweger spectrum disorder (ZSD) commonly present with vision loss due to mutations in PEX genes required for peroxisome assembly and function. Here, we evaluate PEX1 retinal gene augmentation therapy in a mouse model of mild ZSD beari
Autor:
Stéphane Turcotte, Katia Mellal, Ramesh Chingle, Mukandila Mulumba, Samy Omri, Lylia Dif-Yaiche, Sylvain Chemtob, Huy Ong, William D. Lubell
Publikováno v:
Biomedicines, Vol 6, Iss 4, p 98 (2018)
Modulation of the cluster of differentiation-36 receptor (CD36) has proven promising for dampening pro-inflammatory macrophage signaling. For example, azapeptides (e.g., 1 and 2) bind CD36 selectively with high affinity, mitigate Toll-like receptor (
Externí odkaz:
https://doaj.org/article/1e4d6c5f99664b619bd18102e4c19a2d