Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Samuli Auno"'
Autor:
Lotta Pohjolainen, Sini M. Kinnunen, Samuli Auno, Alexandros Kiriazis, Saana Pohjavaara, Julia Kari-Koskinen, Matej Zore, Mikael Jumppanen, Jari Yli-Kauhaluoma, Virpi Talman, Heikki Ruskoaho, Mika J. Välimäki
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background The prevalence of heart failure is constantly increasing, and the prognosis of patients remains poor. New treatment strategies to preserve cardiac function and limit cardiac hypertrophy are therefore urgently needed. Human induced
Externí odkaz:
https://doaj.org/article/e9849cfeb7e34860b937a7a7a18376a5
Autor:
Tony S. Eteläinen, Tommi P. Kilpeläinen, Adele Ignatius, Samuli Auno, Francesca De Lorenzo, Johanna K. Uhari-Väänänen, Ulrika H. Julku, Timo T. Myöhänen
Publikováno v:
Neuropharmacology. 218
Parkinson's disease (PD) is characterized by degeneration of nigrostriatal dopaminergic neurons and accumu-lation of alpha-synuclein (alpha Syn) as Lewy bodies. Currently, there is no disease-modifying therapy available for PD. We have shown that a s
Publikováno v:
SSRN Electronic Journal.
Autor:
Pyry M. J. Dillemuth, Timo T. Myöhänen, Maija Lahtela-Kakkonen, Henri T. Pätsi, Samuli Auno, Erik A.A. Wallén, Khaled Arja, Tommi Kilpeläinen
Publikováno v:
ACS Medicinal Chemistry Letters
Different five-membered nitrogen-containing heteroaromatics in the position of the typical electrophilic group in prolyl oligopeptidase (PREP) inhibitors were investigated and compared to tetrazole. The 2-imidazoles were highly potent inhibitors of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2b18fee964d75dc4dbbf9ec8da5bbf
http://hdl.handle.net/10138/336056
http://hdl.handle.net/10138/336056
Autor:
Samuli Auno, Sampo Kurvonen, Poul Henning Jensen, Tommi Kilpeläinen, Lydia Zouzoula, Susanna Norrbacka, Hengjing Cui, Iiris Hovatta, Kalevi Trontti, Timo T. Myöhänen
Publikováno v:
Journal of Cellular and Molecular Medicine
Cui, H, Kilpeläinen, T, Zouzoula, L, Auno, S, Trontti, K, Kurvonen, S, Norrbacka, S, Hovatta, I, Jensen, P H & Myöhänen, T T 2021, ' Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy ', Journal of Cellular and Molecular Medicine, vol. 25, no. 20, pp. 9634-9646 . https://doi.org/10.1111/jcmm.16910
Cui, H, Kilpeläinen, T, Zouzoula, L, Auno, S, Trontti, K, Kurvonen, S, Norrbacka, S, Hovatta, I, Jensen, P H & Myöhänen, T T 2021, ' Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy ', Journal of Cellular and Molecular Medicine, vol. 25, no. 20, pp. 9634-9646 . https://doi.org/10.1111/jcmm.16910
Multiple system atrophy (MSA) is a fatal neurodegenerative disease where the histopathological hallmark is glial cytoplasmic inclusions in oligodendrocytes, rich of aggregated alpha-synuclein (aSyn). Therefore, therapies targeting aSyn aggregation an
Autor:
Heikki Ruskoaho, Mika J. Välimäki, Samuli Auno, Jari Yli-Kauhaluoma, Ingo B. Aumüller, Virpi Talman, Henri Xhaard, Gustav Boije af Gennäs, Sini Kinnunen, Tanja Bruun, Mikael Jumppanen
Publikováno v:
Journal of Medicinal Chemistry
Transcription factors GATA4 and NKX2-5 directly interact and synergistically activate several cardiac genes and stretch-induced cardiomyocyte hypertrophy. Previously, we identified phenylisoxazole carboxamide 1 as a hit compound, which inhibited the
Autor:
Samuli Auno, Anu Vaikkinen, Gianmario Scotti, Petteri Piepponen, Juha-Pekka Hieta, Jaakko Kopra, Markus Haapala, Heikki Räikkönen, Tiina J. Kauppila
Publikováno v:
Journal of the American Society for Mass Spectrometry. 28:1060-1065
In mass spectrometry imaging of tissues, the size of structures that can be distinguished is determined by the spatial resolution of the imaging technique. Here, the spatial resolution of IR laser ablation is markedly improved by increasing the dista
Autor:
Gabor Foldes, Gustav Boije af Gennäs, Samuli Auno, Lotta Pohjolainen, Sini Kinnunen, Jari Yli-Kauhaluoma, Virpi Talman, Mikael Jumppanen, S. Tuuli Karhu, Mika J. Välimäki, Heikki Ruskoaho, Robert S. Leigh
Publikováno v:
Archives of Toxicology
Safety assessment of drug candidates in numerous in vitro and experimental animal models is expensive, time consuming and animal intensive. More thorough toxicity profiling already in the early drug discovery projects using human cell models, which m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82948851bd15a94e2fddbdbd8b3787ca
http://hdl.handle.net/10138/240364
http://hdl.handle.net/10138/240364
Autor:
Henri Xhaard, Samuli Auno, Lari Lehtiö, Yuezhou Zhang, Leo Ghemtio, Gustav Boije af Gennäs, Harikanth Venkannagari, Zulfa Awol, Mikael Jumppanen, Jari Yli-Kauhaluoma, Mirko M. Maksimainen
The human O-acetyl-ADP-ribose deacetylase MDO1 is a mono-ADP-ribosylhydrolase involved in the reversal of post-translational modifications. Until now MDO1 has been poorly characterized, partly since no ligand is known besides adenosine nucleotides. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a4ef9050e8f6174f78b631bcab2582
http://urn.fi/urn:nbn:fi-fe201902266264
http://urn.fi/urn:nbn:fi-fe201902266264
Autor:
Antti Mikael Jumppanen, Sini Kinnunen, Mika Juhani Välimäki, Samuli Auno, Gustav Boije af Gennäs, Henri Xhaard, Virpi Talman, Heikki Juhani Ruskoaho, Jari Tapani Yli-Kauhaluoma
Publikováno v:
University of Helsinki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::14eb09cef4135786bb1c38380162285c
https://researchportal.helsinki.fi/en/publications/a8abbdca-2e6f-4fe8-b688-e7f78b42fcb9
https://researchportal.helsinki.fi/en/publications/a8abbdca-2e6f-4fe8-b688-e7f78b42fcb9