A new dawn for monoclonal antibodies against antimicrobial resistant bacteria

Autor: Marco Troisi, Eleonora Marini, Valentina Abbiento, Samuele Stazzoni, Emanuele Andreano, Rino Rappuoli

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

Antimicrobial resistance (AMR) is a quickly advancing threat for human health worldwide and almost 5 million deaths are already attributable to this phenomenon every year. Since antibiotics are failing to treat AMR-bacteria, new tools are needed, and

Externí odkaz: https://doaj.org/article/ca91b9b359d94e90806e2ec34a284e68

Neuartige Poxin‐stabile cGAMP‐Derivate als bemerkenswerte STING‐Agonisten

Autor: Samuele Stazzoni, Daniel F. R. Böhmer, Fabian Hernichel, Dilara Özdemir, Aikaterini Pappa, David Drexler, Stefan Bauernfried, Gregor Witte, Mirko Wagner, Simon Veth, Karl‐Peter Hopfner, Veit Hornung, Lars M. König, Thomas Carell

Publikováno v: Angewandte Chemie. 134

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b954dd7527ee4ec5acdc2b86d198f8a
https://doi.org/10.1002/ange.202207175

A Click‐Chemistry Linked 2′3′‐cGAMP Analogue

Autor: David Jan Drexler, Samuele Stazzoni, Gregor Witte, Hidenori Okamura, Felix Müller, Alexander Pichler, Thomas Carell, Karl-Peter Hopfner, Clemens Reto Dialer, Simon Veth

Publikováno v: Chemistry – A European Journal

2'3'-cGAMP is an uncanonical cyclic dinucleotide where one A and one G base are connected via a 3'-5' and a unique 2'-5' linkage. The molecule is produced by the cyclase cGAS in response to cytosolic DNA binding. cGAMP activates STING and hence one o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d460222f310744fa407e7cc3e5d3070
https://doi.org/10.1002/chem.201805409

Synthesis of dicarba-cyclooctapeptide Somatostatin analogs by conventional and MW-assisted RCM: A study about the impact of the configuration at C α of selected amino acids

Autor: Alfonso Carotenuto, Anna Maria Papini, Diego Brancaccio, Giuseppina Sabatino, Samuele Stazzoni, Marco Chinol, Mauro Ginanneschi, Paolo Rovero, Marco Lumini, Alessandro Pratesi, Ettore Novellino

Publikováno v: Chemical engineering and processing
122 (2017): 365–372. doi:10.1016/j.cep.2017.02.005
info:cnr-pdr/source/autori:Pratesi A.; Stazzoni S.; Lumini M.; Sabatino G.; Carotenuto A.; Brancaccio D.; Novellino E.; Chinol M.; Rovero P.; Ginanneschi M.; Papini A.M./titolo:Synthesis of dicarba-cyclooctapeptide Somatostatin analogs by conventional and MW-assisted RCM: A study about the impact of the configuration at C? of selected amino acids/doi:10.1016%2Fj.cep.2017.02.005/rivista:Chemical engineering and processing (Print)/anno:2017/pagina_da:365/pagina_a:372/intervallo_pagine:365–372/volume:122

This work describes the synthesis of thirteen cyclooctapeptides dicarba-analogues of Somatostatin, containing l- or d-allylglycine (Agl) residues at the termini of the peptide chain, through on resin Ring Closing Metathesis (RCM) of the linear octape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7379a30f423e837c8a6c3d550c178220
https://doi.org/10.1016/j.cep.2017.02.005

5-Formylcytosine Could Be a Semipermanent Base in Specific Genome Sites

Autor: Markus Müller, Thomas Carell, Meng Su, Angie Kirchner, Samuele Stazzoni, Arne S. Schröder, Mirko Wagner

Publikováno v: Angewandte Chemie International Edition

5-Formyl-2’-deoxycytosine (fdC) is a recently discovered epigenetic base in the genome of stem cells, with yet unknown functions. Sequencing data show that the base is enriched in CpG islands of promoters and hence likely involved in the regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c5b24089cbdc86d49fbe2b66c58968
https://pubmed.ncbi.nlm.nih.gov/27561097