Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Samuele Marro"'
Autor:
Anna Podleśny-Drabiniok, Gloriia Novikova, Yiyuan Liu, Josefine Dunst, Rose Temizer, Chiara Giannarelli, Samuele Marro, Taras Kreslavsky, Edoardo Marcora, Alison Mary Goate
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Genetic and experimental evidence suggests that Alzheimer’s disease (AD) risk alleles and genes may influence disease susceptibility by altering the transcriptional and cellular responses of macrophages, including microglia, to damage of l
Externí odkaz:
https://doaj.org/article/027d5a15040d494d9ba7883e1eb3c81b
Autor:
Alice K. Min, Behnam Javidfar, Roy Missall, Donald Doanman, Madel Durens, Samantha St Vil, Zahra Masih, Mara Graziani, Annika Mordelt, Samuele Marro, Lotje de Witte, Benjamin K. Chen, Talia H. Swartz, Schahram Akbarian
Publikováno v:
bioRxiv
The central nervous system (CNS) is a major human immunodeficiency virus type 1 reservoir. Microglia are the primary target cell of HIV-1 infection in the CNS. Current models have not allowed the precise molecular pathways of acute and chronic CNS mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24ec0b7d17cf2c082815a66f9072942
https://europepmc.org/articles/PMC10168358/
https://europepmc.org/articles/PMC10168358/
Autor:
Anna Podlesny-Drabiniok, Gloriia Novikova, Yiyuan Liu, Josefine Dunst, Rose Temizer, Chiara Giannarelli, Samuele Marro, Taras Kreslavsky, Edoardo Marcora, Alison Mary Goate
Publikováno v:
bioRxiv
BackgroundGenetic and experimental evidence strongly implicates myeloid cells in the etiology of AD and suggests that AD-associated alleles and genes may modulate disease risk by altering the transcriptional and cellular responses of macrophages (lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efaa3ba163f13c65ac90a656ff4378a
https://europepmc.org/articles/PMC9948946/
https://europepmc.org/articles/PMC9948946/
Autor:
Joel M. Chick, Nickolas A. Bacon, Piotr Sicinski, Emanuelle Jecrois, Yichen Wang, Richard O. Han, Tobias Otto, Chen Chu, Wojciech Michowski, Lijun Liu, Samanta Sharma, Brian J. Abraham, Aleksandra Kolodziejczyk, Phatthamon Laphanuwat, Mitchell Li Cheong Man, Samuele Marro, Lars Anders, Anne Fassl, Alan M. Moses, Katharine E. Sweeney, Steven P. Gygi, Richard A. Young, Lukas M. Dunkl, Tian Zhang, Yan Geng, Jan M. Suski, Marius Wernig, Cheng Li, Daniel S. Day
Publikováno v:
Mol Cell
Elsevier
Elsevier
© 2020 Elsevier Inc. The cyclin-dependent kinase 1 (Cdk1) drives cell division. To uncover additional functions of Cdk1, we generated knockin mice expressing an analog-sensitive version of Cdk1 in place of wild-type Cdk1. In our study, we focused on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920d44e2f7a6a1a19b7a335e52b35122
https://europepmc.org/articles/PMC7214218/
https://europepmc.org/articles/PMC7214218/
Autor:
Samuele Marro, Deborah Chiabrando, Erika Messana, Jens Stolte, Emilia Turco, Emanuela Tolosano, Martina U. Muckenthaler
Publikováno v:
Haematologica, Vol 95, Iss 8 (2010)
Background Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or expor
Externí odkaz:
https://doaj.org/article/cc62847329d14127ad70904a936c0249
Autor:
Howard Y. Chang, Justyna A. Janas, Mavis Li, Yunshuo Tang, Thomas C. Südhof, Daniel Haag, Cheen Euong Ang, Arturo Alvarez Buylla, Orly L. Wapinski, John L.R. Rubenstein, Soham Chanda, Nan Yang, Moritz Mall, Marius Wernig, Henrik Ahlenius, Yi Han Ng, Quetzal Flores, Samuele Marro
Publikováno v:
Nature Methods. 14:621-628
Approaches to differentiating pluripotent stem cells (PSCs) into neurons currently face two major challenges-(i) generated cells are immature, with limited functional properties; and (ii) cultures exhibit heterogeneous neuronal subtypes and maturatio
Autor:
Tyler Fair, Thomas C. Südhof, Zhenjie Zhang, Samuele Marro, Kristin L. Arendt, Bo Zhou, Marius Wernig, Lu Chen, Christopher Patzke, Nan Yang, Yingsha Zhang
Fragile X syndrome (FXS) is an X chromosome-linked disease leading to severe intellectual disabilities. FXS is caused by inactivation of the fragile X mental retardation 1 (FMR1) gene, but how FMR1 inactivation induces FXS remains unclear. Using huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c11b962813c4403d207d5769ad1c23e
https://europepmc.org/articles/PMC6317709/
https://europepmc.org/articles/PMC6317709/
Autor:
Thomas C. Südhof, Sean Merrill, Hannah Shelby, Soham Chanda, Justyna A. Janas, Hannes Vogel, Justin H. Trotter, Marius Wernig, Samuele Marro, Nan Yang, Giulio Valperga, Issa Yousif, Bo Zhou, M. Yashar S. Kalani
Publikováno v:
Neuron
The autism-associated synaptic-adhesion gene Neuroligin-4 (NLGN4) is poorly conserved evolutionarily, limiting conclusions from Nlgn4 mouse models for human cells. Here, we show that the cellular and subcellular expression of human and murine Neuroli
Autor:
Yi Han Ng, Thomas C. Südhof, Howard Y. Chang, Qian Yi Lee, Soham Chanda, Thomas Vierbuchen, Orly L. Wapinski, Paul G. Giresi, Daniela Drechsel, Marius Wernig, Norma F. Neff, Kun Qu, François Guillemot, Samuele Marro, Anne Brunet, Ben Martynoga, Diogo S. Castro, Daniel R. Fuentes, Ashley E. Webb
Publikováno v:
Cell. 155:621-635
SummaryDirect lineage reprogramming is a promising approach for human disease modeling and regenerative medicine, with poorly understood mechanisms. Here, we reveal a hierarchical mechanism in the direct conversion of fibroblasts into induced neurona
Autor:
Jason P. Covy, Soham Chanda, Yingsha Zhang, Thomas C. Südhof, ChangHui Pak, Lu Chen, Nan Yang, Claudio Acuna, Wei Xu, Christopher Patzke, Henrik Ahlenius, Tamas Danko, Zhenjie Zhang, Samuele Marro, Marius Wernig, Yan Han
Publikováno v:
Neuron. 78(5):785-798
SummaryAvailable methods for differentiating human embryonic stem cells (ESCs) and induced pluripotent cells (iPSCs) into neurons are often cumbersome, slow, and variable. Alternatively, human fibroblasts can be directly converted into induced neuron