Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Samuele Maramai"'
Autor:
Giusy Tassone, Samuele Maramai, Marco Paolino, Stefania Lamponi, Federica Poggialini, Elena Dreassi, Elena Petricci, Stefano Alcaro, Cecilia Pozzi, Isabella Romeo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Bioconjugation is one of the most promising strategies to improve drug delivery, especially in cancer therapy. Biomolecules such as bile acids (BAs) have been intensively explored as carriers, due to their peculiar physicochemical properties
Externí odkaz:
https://doaj.org/article/1a4c84aa763544cdb95cf8741a3df437
Autor:
Antonella Brizzi, Samuele Maramai, Francesca Aiello, Maria Camilla Baratto, Federico Corelli, Claudia Mugnaini, Marco Paolino, Francesco Scorzelli, Carlo Aldinucci, Luciano De Petrocellis, Cinzia Signorini, Federica Pessina
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13580 (2022)
α-Lipoic acid is a sulfur-containing nutrient endowed with pleiotropic actions and a safe biological profile selected to replace the unsaturated alkyl acid of capsaicin with the aim of obtaining lipoic amides potentially active as a TRPV1 ligand and
Externí odkaz:
https://doaj.org/article/dfed174b768243ed8aecab73d600cf76
Autor:
Antonella Brizzi, Alfonso Trezza, Ottavia Spiga, Samuele Maramai, Francesco Scorzelli, Simona Saponara, Fabio Fusi
Publikováno v:
Molbank, Vol 2021, Iss 3, p M1258 (2021)
Quercetin and ferulic acid are two phytochemicals extensively represented in the plant kingdom and daily consumed in considerable amounts through diets. Due to a common phenolic structure, these two molecules share several pharmacological properties,
Externí odkaz:
https://doaj.org/article/ab69e5e920104c85a6d78050eab183a2
Autor:
Giusy Tassone, Marco Mazzorana, Stefano Mangani, Elena Petricci, Elena Cini, Giuseppe Giannini, Cecilia Pozzi, Samuele Maramai
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9458 (2022)
Heat shock protein 90 (Hsp90) is a ubiquitous molecular chaperone that stabilizes client proteins in a folded and functional state. It is composed of two identical and symmetrical subunits and each monomer consists of three domains, the N-terminal (N
Externí odkaz:
https://doaj.org/article/36a7d552437642ad946f7f7e91da1c5c
Autor:
Laura Micheli, Samuele Maramai, Alessandra Toti, Valentina Ferrara, Clara Ciampi, Lorenzo Di Cesare Mannelli, Carla Ghelardini
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8428 (2022)
Neuroinflammation is a key pathological event shared by different diseases affecting the nervous system. Since the underlying mechanism of neuroinflammation is a complex and multifaceted process, current pharmacological treatments are unsatisfactory
Externí odkaz:
https://doaj.org/article/0ab7343511284b8b82190ad484ae9164
Autor:
Elena Petricci, Simone Zurzolo, Camilla Matassini, Samuele Maramai, Francesca Cardona, Andrea Goti, Maurizio Taddei
Publikováno v:
Molecules, Vol 27, Iss 15, p 4762 (2022)
A general method for the synthesis of pyrrolizidine derivatives using an intramolecular hydroaminomethylation protocol (HAM) under microwave (MW) dielectric heating is reported. Starting from a 3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-vinylpyrrolid
Externí odkaz:
https://doaj.org/article/438ab9c3b4ca4a66ada6edea3ac0f44a
Autor:
Samuele Maramai, Sandra Gemma, Simone Brogi, Giuseppe Campiani, Stefania Butini, Holger Stark, Margherita Brindisi
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
D3 receptors represent a major focus of current drug design and development of therapeutics for dopamine-related pathological states. Their close homology with the D2 receptor subtype makes the development of D3 selective antagonists a challenging ta
Externí odkaz:
https://doaj.org/article/92280543732a4783801504a85dcb3218
Autor:
Isabella Romeo, Antonella Brizzi, Federica Pessina, Francesca Alessandra Ambrosio, Francesca Aiello, Carmela Belardo, Gabriele Carullo, Giosuè Costa, Luciano De Petrocellis, Maria Frosini, Livio Luongo, Samuele Maramai, Marco Paolino, Aniello Schiano Moriello, Claudia Mugnaini, Francesco Scorzelli, Sabatino Maione, Federico Corelli, Vincenzo Di Marzo, Stefano Alcaro, Anna Artese
Publikováno v:
Journal of Medicinal Chemistry. 66:6994-7015
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d13ff81e05df56efeb83a125a9dee633
https://doi.org/10.1021/acs.jmedchem.3c00447
https://doi.org/10.1021/acs.jmedchem.3c00447
Autor:
Fabrizio Manetti, Luisa Maresca, Enrica Crivaro, Sara Pepe, Elena Cini, Snigdha Singh, Paolo Governa, Samuele Maramai, Giuseppe Giannini, Barbara Stecca, Elena Petricci
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1329-1336
A virtual screening approach based on a five-feature pharmacophoric model for negative modulators of GLI1 was applied to databases of commercially available compounds. The resulting quinoline derivatives showed significant ability to reduce the GLI1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7240b4e76b611d047e71c5a70ec98a6c
https://doi.org/10.1021/acsmedchemlett.2c00249
https://doi.org/10.1021/acsmedchemlett.2c00249
Autor:
Marco Paolino, Mariagrazia Rullo, Samuele Maramai, Modesto de Candia, Leonardo Pisani, Marco Catto, Claudia Mugnaini, Antonella Brizzi, Andrea Cappelli, Massimo Olivucci, Federico Corelli, Cosimo D. Altomare
Publikováno v:
RSC Med Chem
Neurodegenerative diseases are multifactorial disorders characterized by protein misfolding, oxidative stress, and neuroinflammation, finally resulting in neuronal loss and cognitive dysfunctions. Nowadays, an attractive strategy to improve the class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c33966568eda0ece2fc2d2b4721803d
https://doi.org/10.1039/d2md00042c
https://doi.org/10.1039/d2md00042c