Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Samuele Lodovichi"'
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112060- (2023)
Summary: The nucleolytic processing (resection) of a DNA double-strand break (DSB) is a critical step to repair the lesion by homologous recombination (HR). PARylation, which is the attachment of poly(ADP-ribose) (PAR) units to specific targets by PA
Externí odkaz:
https://doaj.org/article/a122f8c971014469b41152925330e687
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
In budding yeast, the 53BP1 ortholog Rad9 limits the resection nucleolytic processing of DNA double strand breaks. Here the authors reveal that Rad9 promotes long tract gene conversions, BIR and CO, during the HR repair of a DSB via modulation of Sgs
Externí odkaz:
https://doaj.org/article/08beea997c6d4a558a57c65b6a2aa622
Publikováno v:
Microbial Cell, Vol 7, Iss 7, Pp 162-174 (2020)
Technological advances are continuously revealing new genetic variants that are often difficult to interpret. As one of the most genetically tractable model organisms, yeast can have a central role in determining the consequences of human genetic var
Externí odkaz:
https://doaj.org/article/5e091684c89649249030957d9dcd1a9d
Autor:
Luisa Maresca, Samuele Lodovichi, Alessandra Lorenzoni, Tiziana Cervelli, Rossella Monaco, Laura Spugnesi, Mariella Tancredi, Elisabetta Falaschi, Katia Zavaglia, Elisabetta Landucci, Manuela Roncella, Caterina Congregati, Angiolo Gadducci, Antonio Giuseppe Naccarato, Maria Adelaide Caligo, Alvaro Galli
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
In this study, we determined if BRCA1 partners involved in DNA double-strand break (DSB) and mismatch repair (MMR) may contribute to breast and ovarian cancer development. Taking advantage the functional conservation of DNA repair pathways between ye
Externí odkaz:
https://doaj.org/article/e639c8c962944410837a5ab480c63c8e
Publikováno v:
Microbial Cell
Microbial Cell, Vol 7, Iss 7, Pp 162-174 (2020)
Microbial Cell, Vol 7, Iss 7, Pp 162-174 (2020)
Technological advances are continuously revealing new genetic variants that are often difficult to interpret. As one of the most genetically tractable model organisms, yeast can have a central role in determining the consequences of human genetic var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407954ccaeb24855a8338ff328df5b6d
https://doi.org/10.15698/mic2020.07.721
https://doi.org/10.15698/mic2020.07.721
Autor:
Samuele Lodovichi, Francesca Bellè, Alberto Mercatanti, Laura Spugnesi, Cristina Cozzani, Maria Adelaide Caligo, Tiziana Cervelli, Alvaro Galli
Publikováno v:
FEMS yeast research. 22(1)
The breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2, are key players in the homologous recombination (HR) repair pathway and act as tumor suppressors by maintaining genome stability. The yeast Saccharomyces cerevisiae has no BRCA1/2 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a65c157554660aac9d90b937477574
https://pubmed.ncbi.nlm.nih.gov/35472165
https://pubmed.ncbi.nlm.nih.gov/35472165
Autor:
Alessandra Lorenzoni, Maria A. Caligo, Francesca Bellè, Samuele Lodovichi, Tiziana Cervelli, Cristina Cozzani, Luisa Maresca, Alvaro Galli
Publikováno v:
Mutagenesis. 35:189-195
Evaluation of the functional impact of germline BRCA1 variants that are likely to be associated to breast and ovarian cancer could help to investigate the mechanism of BRCA1 tumorigenesis. Expression of pathogenic BRCA1 missense variants increased ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204b9ad8aca97cbc71631e822d671fd7
https://doi.org/10.1093/mutage/gez043
https://doi.org/10.1093/mutage/gez043
Publikováno v:
Oncotarget
Knowledge of interaction network between different proteins can be a useful tool in cancer therapy. To develop new therapeutic treatments, understanding how these proteins contribute to dysregulated cellular pathways is an important task. PARP1 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2b5b39e554bb53fe40dcba654689ea
https://doi.org/10.18632/oncotarget.26812
https://doi.org/10.18632/oncotarget.26812
Autor:
Francesca Bellè, Alberto Mercatanti, Samuele Lodovichi, Caterina Congregati, Chiara Guglielmi, Mariella Tancredi, Maria Adelaide Caligo, Tiziana Cervelli, Alvaro Galli
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 4049
Germline mutations in the BRCA1 gene have been reported to increase the lifetime risk of developing breast and/or ovarian cancer (BOC). By new sequencing technologies, numerous variants of uncertain significance (VUS) are identified. It is mandatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76fca213393291025eb57e35e0ec3dbe
https://doi.org/10.3390/ijms23074049
https://doi.org/10.3390/ijms23074049
A DNA double strand break (DSB) is primed for homologous recombination (HR) repair through the nucleolytic processing (resection) of its ends, leading to the formation of a 3′ single-stranded DNA (ssDNA). Generation of the ssDNA is accompanied by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b4e337e19c7bd96ffe17ad5b9e3c5d
