Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Samuele De Minicis"'
Autor:
Sören V Siegmund, Monika Schlosser, Frank A Schildberg, Ekihiro Seki, Samuele De Minicis, Hiroshi Uchinami, Christian Kuntzen, Percy A Knolle, Christian P Strassburg, Robert F Schwabe
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150893 (2016)
Serum amyloid A (SAA) is an evolutionary highly conserved acute phase protein that is predominantly secreted by hepatocytes. However, its role in liver injury and fibrogenesis has not been elucidated so far. In this study, we determined the effects o
Externí odkaz:
https://doaj.org/article/57b39f380dc549c4b6086d463d47b92f
Autor:
Samuele De Minicis, Laura Agostinelli, Chiara Rychlicki, Gian Pio Sorice, Stefania Saccomanno, Cinzia Candelaresi, Andrea Giaccari, Luciano Trozzi, Irene Pierantonelli, Eleonora Mingarelli, Marco Marzioni, Giovanna Muscogiuri, Melania Gaggini, Antonio Benedetti, Amalia Gastaldelli, Maria Guido, Gianluca Svegliati-Baroni
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97136 (2014)
NAFLD is the most common liver disease worldwide but it is the potential evolution to NASH and eventually to hepatocellular carcinoma (HCC), even in the absence of cirrhosis, that makes NAFLD of such clinical importance.we aimed to create a mouse mod
Externí odkaz:
https://doaj.org/article/cd2888c23b1e42fdb789e478ced6d534
Autor:
Chiara Rychlicki, I. Pierantonelli, C. Pinto, C. Saponaro, Amalia Gastaldelli, Saverio Cinti, Samuele De Minicis, Gianluca Svegliati-Baroni, Valeria Manghina, Marco Marzioni, Luciano Trozzi, Emma Buzzigoli, E. Mingarelli, Sergio Uzzau, Melania Gaggini, Laura Agostinelli, Antonio Giordano, Debora Maria Giordano, Loris Sartini, Cristina Fraumene
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Non-Alcoholic Fatty Liver Disease (NAFLD) represents the most common form of chronic liver injury and can progress to cirrhosis and hepatocellular carcinoma. A “multi-hit” theory, involving high fat diet and signals from the gut-liver axis, has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc72a58e5e8487bc57e207201bf0514
http://link.springer.com/article/10.1038/s41598-017-11744-6
http://link.springer.com/article/10.1038/s41598-017-11744-6
Autor:
Samuele De Minicis, Filippo Antonini, Nico Pagano, P. Rossetti, S. Piergallini, Elisabetta Buscarini, V. Belfiori, Massimiliano Lo Cascio, B. Marraccini, Raffaele Pezzilli, Elena Andrenacci, Giampiero Macarri
Publikováno v:
Pancreas. 46(4)
Objectives We have previously shown that at least 50% of patients with asymptomatic chronic pancreatic hyperenzymemia (ACPH) may develop morphological pancreatic alterations. Endoscopic ultrasonography (EUS) may detect small lesions, and its sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e89c2011cb4cbc4b98d8517fe823700
https://pubmed.ncbi.nlm.nih.gov/28196017
https://pubmed.ncbi.nlm.nih.gov/28196017
Autor:
Laura Agostinelli, Chiara Rychlicki, Antonio Benedetti, Jesus M. Banales, Stefania Saccomanno, Luciano Trozzi, Samuele De Minicis, Luca Maroni, E. Mingarelli, Cinzia Candelaresi, Gianluca Svegliati Baroni, Marco Marzioni
Publikováno v:
Hepatology. 60:1324-1335
The activation of the biliary stem-cell signaling pathway hairy and enhancer of split 1/pancreatic duodenal homeobox-1 (Hes-1/PDX-1) in mature cholangiocytes determines cell proliferation. Neurogenin-3 (Ngn-3) is required for pancreas development and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13782adf24e635eb59149c6c45de9ebd
https://doi.org/10.1002/hep.27262
https://doi.org/10.1002/hep.27262
Autor:
Floriana Facchetti, Fabio Piscaglia, Alessandro Granito, S. Gemini, Sara Vavassori, Davide Bitetto, Pierluigi Toniutto, Samuele De Minicis, Luca Faloppi, Mario Scartozzi, Cristian Loretelli, Giammarco Fava, Antonietta D'Errico, Italo Bearzi, Maristella Bianconi, Stefano Cascinu, Sara Marinelli, Gianluca Svegliati Baroni, Antonio Benedetti, Massimo Colombo, L. Venerandi, Luigi Bolondi, Alessandra Mandolesi, Massimo Iavarone, Riccardo Giampieri
Publikováno v:
International Journal of Cancer. 135:1247-1256
Although new treatment modalities changed the global approach to hepatocellular carcinoma (HCC), this disease still represents a medical challenge. Currently, the therapeutic stronghold is sorafenib, a tyrosine kinase inhibitor (TKI) directed against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::801adccb1207cef969ccb947e4326ae2
https://doi.org/10.1002/ijc.28772
https://doi.org/10.1002/ijc.28772
Autor:
David A. Brenner, Federico Mocchegiani, Laura Agostinelli, Luciano Trozzi, Marco Marzioni, Samuele De Minicis, Cinzia Candelaresi, Chiara Rychlicki, Stefania Saccomanno, Cristina Millán, Marco Vivarelli, Gianluca Svegliati-Baroni, Antonio Benedetti, Ramon Bataller
Publikováno v:
The American Journal of Pathology; Vol 183
Semaphorin7A (SEMA7A) is a membrane-anchored protein involved in immune and inflammatory responses, exerting an effect on pulmonary fibrosis. Thus, we aimed to investigate the role of SEMA7A in hepatic fibrosis. Liver injury was induced in vivo by ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78846fa87cdea6aab49f6091f50a8d93
https://doi.org/10.1016/j.ajpath.2013.05.030
https://doi.org/10.1016/j.ajpath.2013.05.030
Autor:
Ana Cristina Dragomir, Costica Aloman, Johannes Kluwe, Myoung Kuk Jang, Geum-Youn Gwak, Dianne H. Dapito, Jingjing Jiao, Richard A. Friedman, Robert F. Schwabe, Nina D. Guenther, Samuele De Minicis, Ingmar Mederacke, Jean Philippe Pradere
Publikováno v:
Hepatology. 58:1461-1473
The development of liver fibrosis constitutes one of the major complications of chronic liver disease with many clinical consequences such as the development of esophageal varices and ascites being directly related to the presence of liver fibrosis (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16b54c5a7904c585b421582c52c43e28
https://doi.org/10.1002/hep.26429
https://doi.org/10.1002/hep.26429
Publikováno v:
Current Pharmaceutical Design. 19:5239-5249
NAFLD is the most common liver disease worldwide but it is the potential evolution to cirrhosis and hepatocellular carcinoma (HCC) that makes NAFLD of such clinical importance. The current work provides an overview of the main mechanims and potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ee76f9b4e874560dc270027586d3e1
https://doi.org/10.2174/1381612811319290006
https://doi.org/10.2174/1381612811319290006
Autor:
Samuele De Minicis, Debora Maria Giordano, Luciano Trozzi, C. Pinto, Chiara Rychlicki, Marco Marzioni, Antonio Benedetti, Tom H. Karlsen, Laura Agostinelli, Luca Maroni, Jesus M. Banales, Stefania Saccomanno, Gianluca Svegliati Baroni, Espen Melum
Publikováno v:
The American journal of pathology. 187(2)
Microbial products are thought to influence the progression of cholangiopathies, in particular primary sclerosing cholangitis (PSC). Inflammasomes are molecular platforms that respond to microbial products through the synthesis of proinflammatory cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4c42e8d8170b84376e0517fbd267fc
https://pubmed.ncbi.nlm.nih.gov/27912077
https://pubmed.ncbi.nlm.nih.gov/27912077