Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Samuel X. Shi"'
Autor:
Ning Liu, Jinrui Han, Yadan Li, Yinghua Jiang, Samuel X. Shi, Josephine Lok, Michael Whalen, Aaron S. Dumont, Xiaoying Wang
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract Background Traumatic brain injury (TBI) is a significant cause of death and disability worldwide. The TLR4-NFκB signaling cascade is the critical pro-inflammatory activation pathway of leukocytes after TBI, and modulating this signaling cas
Externí odkaz:
https://doaj.org/article/922b7f40a5f2438fa7c9c792a4b53768
Autor:
Samuel X. Shi, Samuel J. Vodovoz, Yuwen Xiu, Ning Liu, Yinghua Jiang, Prasad V. G. Katakam, Gregory Bix, Aaron S. Dumont, Xiaoying Wang
Publikováno v:
Cells, Vol 11, Iss 13, p 2011 (2022)
In the pathophysiology of hemorrhagic stroke, the perturbation of the neurovascular unit (NVU), a functional group of the microvascular and brain intrinsic cellular components, is implicated in the progression of secondary injury and partially inform
Externí odkaz:
https://doaj.org/article/eb7e2f0c69244715b73d23b1e178f6af
Autor:
Samuel X. Shi, Yu-Jing Li, Trevor S. Wendt, Kaibin Shi, Weina Jin, Qiang Liu, Rayna J. Gonzales
Sphingosine-1-phosphate receptor 1 (S1PR1) is highly expressed in endothelial cells and receptor activation plays an important role in mediating endothelial function and health, thus showing promise as a pharmacologic target for acute ischemic stroke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91581f645449f46abdc4d9499ee57651
https://doi.org/10.1101/2023.03.27.534410
https://doi.org/10.1101/2023.03.27.534410
Publikováno v:
Stroke. 51:967-974
Background and Purpose— Microglia are among the first cells to respond to intracerebral hemorrhage (ICH), but the mechanisms that underlie their activity following ICH remain unclear. IL (interleukin)-15 is a proinflammatory cytokine that orchestra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8017db5b880c6e0702357a265ddb5037
https://doi.org/10.1161/strokeaha.119.028638
https://doi.org/10.1161/strokeaha.119.028638
Autor:
Samuel X Shi, Yuwen Xiu, Kaibin Shi, Logan Glosser, Yinghua Jiang, Ning Liu, Qiang Liu, Xiaoying Wang, Weina Jin
Publikováno v:
Stroke. 53
Intracerebral hemorrhage (ICH), a devastating form of stroke, has a mortality of 40% and no available treatment. Inflammation contributes to the genesis and expansion of perihematomal edema (PHE) in ICH, thus driving secondary injury and subsequent n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eda6fdcda606bbb3e214f81d1601e57
https://doi.org/10.1161/str.53.suppl_1.wp142
https://doi.org/10.1161/str.53.suppl_1.wp142
Publikováno v:
Aging and disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc5f500dd2f4fd9f76e71a673a24924d
https://doi.org/10.14336/ad.2022.21020
https://doi.org/10.14336/ad.2022.21020
Autor:
Samuel X Shi, Boli Zhang, Mardeen S. Karim, Yinghua Jiang, Ning Liu, Xiaoying Wang, Min Zhou, Samuel J. Vodovoz, Aaron S. Dumont
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 3795, p 3795 (2021)
Journal of Clinical Medicine
Journal of Clinical Medicine
Blood-brain barrier (BBB) disruption following ischemic stroke (IS) contributes to hemorrhagic transformation, brain edema, increased neural dysfunction, secondary injury, and mortality. Brain endothelial cells form a para and transcellular barrier t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8de713f40952155b9389b520058491
https://www.mdpi.com/2077-0383/10/17/3795
https://www.mdpi.com/2077-0383/10/17/3795
Autor:
Yadan Li, Shusheng Wang, Jing Yuan, Aaron S. Dumont, Li Lin, Yinghua Jiang, Yinga Wu, Samuel X Shi, Xiaoying Wang, Ning Liu, MingMing Ning, Jinrui Han
Publikováno v:
Translational stroke research. 13(2)
Type 2 diabetes mellitus (T2DM) is a major comorbidity exacerbating ischemic brain injury and impairing post-stroke recovery. Our previous study suggested that recombinant human fibroblast growth factor (rFGF) 21 might be a potent therapeutic targeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c90eefde549e2dd86f67c925711c87
https://pubmed.ncbi.nlm.nih.gov/34523038
https://pubmed.ncbi.nlm.nih.gov/34523038
Autor:
Junwei Hao, Fu-Dong Shi, Mohammed Abdelwahab, Samuel X Shi, Alain Simard, Paul Whiteaker, Ronald Lukas, Qinghua Zhou
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57495 (2013)
Cigarette smoke exposure markedly compromises the ability of the immune system to protect against invading pathogens and tumorigenesis. Nicotine is a psychoactive component of tobacco products that acts as does the natural neurotransmitter, acetylcho
Externí odkaz:
https://doaj.org/article/3bf36803133245879d5a87042f4b2590
Autor:
Zhiguo Li, Xiaojing Cheng, Qiang Liu, Xiao-An Zhang, Minshu Li, Samuel X. Shi, Nan Yao, Zilong Zhu, Ai Guo
Publikováno v:
The Journal of Experimental Medicine
Intracerebral hemorrhage (ICH) provokes brain edema and causes high mortality and disability. This study has identified brain-bound natural killer cells as a key contributor to brain edema and neurological deterioration after ICH.
Perihematomal
Perihematomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1efcbb2d2e543a62d78c8ffd8bb6cc7
https://doi.org/10.1084/jem.20200213
https://doi.org/10.1084/jem.20200213