Výsledky vyhledávání - "Samuel W. Kazer"

Akademický článek

Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection

Autor: Aaron J. Wilk, Joshua O. Marceau, Samuel W. Kazer, Ira Fleming, Vincent N. Miao, Jennyfer Galvez-Reyes, Jason T. Kimata, Alex K. Shalek, Susan Holmes, Julie Overbaugh, Catherine A. Blish

Publikováno v: Genome Medicine, Vol 16, Iss 1, Pp 1-22 (2024)

Abstract Background The Lentivirus human immunodeficiency virus (HIV) causes chronic inflammation and AIDS in humans, with variable rates of disease progression between individuals driven by both host and viral factors. Similarly, simian lentiviruses

Externí odkaz: https://doaj.org/article/040342a1e3f44ef39d97dc79be476a1a

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Akademický článek

Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer

Autor: Mauro Di Pilato, Yun Gao, Yi Sun, Amina Fu, Carina Grass, Thomas Seeholzer, Regina Feederle, Irina Mazo, Samuel W. Kazer, Kevin Litchfield, Ulrich H. von Andrian, Thorsten R. Mempel, Russell W. Jenkins, Daniel Krappmann, Peter Keller

Publikováno v: Journal of Immunotherapy and Precision Oncology, Vol 6, Iss 2, Pp 61-73 (2023)

Introduction: Regulatory T cells (Tregs) play a critical role in the maintenance of immune homeostasis but also protect tumors from immune-mediated growth control or rejection and pose a significant barrier to effective immunotherapy. Inhibition of M

Externí odkaz: https://doaj.org/article/dc5e74a62a884d328a611a253bea0c01

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Akademický článek

HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TRM) CD8+ T-cells is of gr

Externí odkaz: https://doaj.org/article/2214efc1e1c44dd5be878bda8705a958

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Akademický článek

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Glioblastomas (GBM) are frequently resistant to immune checkpoint blockade therapy. Here the authors show that treatment with an agonistic anti-GITR antibody converts tumor infiltrating regulatory T cells to effector cells, overcoming resistance to P

Externí odkaz: https://doaj.org/article/1ab21691b67f4af6a88731fc02b3c2eb

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Akademický článek

MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection

Autor: Sharon Khuzwayo, Maphe Mthembu, Erin W. Meermeier, Sanjay M. Prakadan, Samuel W. Kazer, Thierry Bassett, Kennedy Nyamande, Dilshaad Fakey Khan, Priya Maharaj, Mohammed Mitha, Moosa Suleman, Zoey Mhlane, Dirhona Ramjit, Farina Karim, Alex K. Shalek, David M. Lewinsohn, Thumbi Ndung’u, Emily B. Wong

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi. Despite growing evidence that immune cells at mucosa

Externí odkaz: https://doaj.org/article/37081af5c8b343fc8e6d5d47528bed3c

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Akademický článek

A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood

Autor: Maya Sangesland, Ashraf S. Yousif, Larance Ronsard, Samuel W. Kazer, Alex Lee Zhu, G. James Gatter, Matthew R. Hayward, Ralston M. Barnes, Maricel Quirindongo-Crespo, Daniel Rohrer, Nils Lonberg, Douglas Kwon, Alex K. Shalek, Daniel Lingwood

Publikováno v: Cell Reports, Vol 32, Iss 8, Pp 108065- (2020)

Summary: B cell receptors (BCRs) display a combination of variable (V)-gene-encoded complementarity determining regions (CDRs) and adaptive/hypervariable CDR3 loops to engage antigens. It has long been proposed that the former tune for recognition of

Externí odkaz: https://doaj.org/article/4869d22e49344399b1979bd3c854bad0

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Akademický článek

A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers

Autor: Enrique Martin-Gayo, Michael B. Cole, Kellie E. Kolb, Zhengyu Ouyang, Jacqueline Cronin, Samuel W. Kazer, Jose Ordovas-Montanes, Mathias Lichterfeld, Bruce D. Walker, Nir Yosef, Alex K. Shalek, Xu G. Yu

Publikováno v: Genome Biology, Vol 19, Iss 1, Pp 1-21 (2018)

Abstract Background Human immunity relies on the coordinated responses of many cellular subsets and functional states. Inter-individual variations in cellular composition and communication could thus potentially alter host protection. Here, we explor

Externí odkaz: https://doaj.org/article/49d6cbdd74584883a09c5c667e8590f0

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Akademický článek

A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages

Autor: Robert J. Kimmerling, Gregory Lee Szeto, Jennifer W. Li, Alex S. Genshaft, Samuel W. Kazer, Kristofor R. Payer, Jacob de Riba Borrajo, Paul C. Blainey, Darrell J. Irvine, Alex K. Shalek, Scott R. Manalis

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)

Existing single-cell RNA-seq methods provide the transcriptome of a cellular phenotype at a single time point. Here, Kimmerlinget al. present a microfluidic platform that enables off-chip single-cell RNA-seq after multigenerational lineage tracking u

Externí odkaz: https://doaj.org/article/bea614acf94645cdb3402d06fdfa86be

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