Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Samuel W. Entwisle"'
Autor:
David A. Guertin, Huawei Li, Wen-Yu Hsiao, Su Myung Jung, Sophie Trefely, Judit Villén, Kathryn E. Wellen, Chien-Min Hung, Amelia K. Luciano, AnnMarie Torres, C. Martinez Calejman, Nathaniel W. Snyder, Samuel W. Entwisle
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
mTORC2 phosphorylates AKT in a hydrophobic motif site that is a biomarker of insulin sensitivity. In brown adipocytes, mTORC2 regulates glucose and lipid metabolism, however the mechanism has been unclear because downstream AKT signaling appears unaf
Publikováno v:
Molecular & Cellular Proteomics : MCP
Post-translational modification (PTM) of proteins allows cells to regulate protein functions, transduce signals and respond to perturbations. PTMs expand protein functionality and diversity, which leads to increased proteome complexity. PTM crosstalk
Autor:
Su Myung Jung, Wen-Yu Hsiao, Kathryn E. Wellen, Chien-Min Hung, Amelia K. Luciano, AnnMarie Torres, C. Martinez Calejman, Huawei Li, Judit Villén, Nathaniel W. Snyder, Sophie Trefely, David A. Guertin, Samuel W. Entwisle
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
mTORC2 phosphorylates AKT in a hydrophobic motif site that is a biomarker of insulin sensitivity. In brown adipocytes, mTORC2 regulates glucose and lipid metabolism, however the mechanism has been unclear because downstream AKT signaling appears unaf
Autor:
David A. Guertin, Judit Villén, Robert T. Lawrence, Anthony S. Valente, Camila Martinez Calejman, Samuel W. Entwisle, Chien-Min Hung
Publikováno v:
Mol Cell Proteomics
Stimulating brown adipose tissue (BAT) activity represents a promising therapy for overcoming metabolic diseases. mTORC2 is important for regulating BAT metabolism, but its downstream targets have not been fully characterized. In this study, we apply
Autor:
Robert T. Lawrence, Sankeerth Takkellapati, Garrett R. Mullins, Jennifer M. Pearson, Mitchell E. Granade, Salome Boroda, Samuel W. Entwisle, Thurl E. Harris, Judit Villén, James M. Eaton
Publikováno v:
Journal of Biological Chemistry. 292:20481-20493
Lipins 1, 2, and 3 are Mg2+-dependent phosphatidic acid phosphatases and catalyze the penultimate step of triacylglycerol synthesis. We have previously investigated the biochemistry of lipins 1 and 2 and shown that di-anionic phosphatidic acid (PA) a
Autor:
Anthony S. Valente, Takashi K. Ito, Matt Kaeberlein, Heather Z. Huang, Anthony S. Grillo, Judit Villén, Dayae Kim, Jeehae Han, Samuel W. Entwisle, Masanao Yajima, Miguel Martin-Perez
Publikováno v:
Nature metabolism
Leigh syndrome is a fatal neurometabolic disorder caused by defects in mitochondrial function. mTOR inhibition with rapamycin attenuates disease progression in a mouse model of Leigh syndrome (Ndufs4 KO mouse); however, the mechanism of rescue is unk
Autor:
Jeehae Han, Dayae Kim, Samuel W. Entwisle, Heather Z. Huang, Anthony S. Grillo, Anthony S. Valente, Judit Villén, Matt Kaeberlein, Takashi K. Ito, Masanao Yajima, Miguel Martin-Perez
Leigh syndrome is a fatal neurometabolic disorder caused by defects in mitochondrial function. mTOR inhibition with rapamycin attenuates disease progression in a mouse model of Leigh syndrome (Ndufs4 KO mouse); however, the mechanism of rescue is unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84280ca903e8c9f24c5ba5124e71a3a4
https://doi.org/10.1101/562207
https://doi.org/10.1101/562207
Autor:
David J. Pedersen, Adilson L. Guilherme, Robert T. Lawrence, Michael P. Czech, David A. Guertin, Su Myung Jung, Judit Villén, Sanchez-Gurmaches J, Miguel Martin-Perez, Samuel W. Entwisle
Stimulating brown adipose tissue (BAT) energy expenditure could be a therapy for obesity and related metabolic diseases. Achieving this requires a systems-level understanding of the biochemical underpinnings of thermogenesis. To identify novel metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f284a058a1e0e0f33a5416aa5060fd98
https://doi.org/10.1101/445718
https://doi.org/10.1101/445718
Autor:
Maureen M. Lynes, Alexander Meissner, Laurence Daheron, Emily Brookes, Leonard I. Zon, Jade McPherson, Xin Li, Amelia Cianci, Chad A. Cowan, Prerana Malwadkar, Thorsten M. Schlaeger, Dipti Gupta, Didem Demirbas, Lee L. Rubin, Namyoung Jung, Samuel W. Entwisle, Anne Cherry, Kelly Fitzgerald, Thomas Brickler, Manav Gupta, Akiko Doi, Alexander M. Tsankov, Michelle Godfrey, Blair Bell, George Q. Daley, Karrie Chan, Alex Devine, Andrew P. Feinberg, Andrew Ettenger
Publikováno v:
Nature Biotechnology. 33:58-63
Human induced pluripotent stem cells (hiPSCs1–3) are useful in disease modeling and drug discovery, and they promise to provide a new generation of cell-based therapeutics. To date there has been no systematic evaluation of the most widely used tec