Methylmercury-Induced Metabolic Alterations in Caenorhabditis elegans Are Diet-Dependent

Autor: Nicole Crawford, Megan Martell, Tyson Nielsen, Belal Khalil, Farooq Imtiaz, Etienne Nguidjo, Jennifer L. Newell-Caito, Julia Bornhorst, Tanja Schwerdtle, Samuel W. Caito

Publikováno v: Toxics, Vol 9, Iss 11, p 287 (2021)

Methylmercury (MeHg) is a well-known neurotoxicant; however, its role in metabolic diseases has been gaining wider attention. Chronic exposure to MeHg in human populations shows an association with diabetes mellitus and metabolic syndrome (MS). As th

Externí odkaz: https://doaj.org/article/dedb094b658041e3a0e9d01f44b74e8e

Contributors

Autor: Jan Aaseth, Peter Aggett, Antero Aitio, Agneta Åkesson, Maria Albin, Jan Alexander, Christian B.I. Andersen, Ole Andersen, Pietro Apostoli, Michael Aschner, Rowa Bakadlag, Lars Barregard, David C. Bellinger, Ingvar A. Bergdahl, Balazs Berlinger, Alfred Bernard, Carolina Bigert, Poul Bjerregaard, Robyn Blain, Lennart K. Blomqvist, Beatrice Bocca, Stephan Bose-O'Reilly, Karin Broberg, Ronald P. Brown, Esben Budtz-Jørgensen, Samuel W. Caito, Tiffany Carle, Chien-Jen Chen, Xiao Chen, Lung-Chi Chen, C.-H. Selene J. Chou, Mitchell D. Cohen, Max Costa, Giuseppe De Palma, Alison Elder, Carl-Gustaf Elinder, Bengt Fadeel, Obaid M. Faroon, Bruce A. Fowler, Hitomi Fujishiro, Silvia Fustinoni, Lars Gerhardsson, Philippe Grandjean, Per Gustavsson, Yolanda Hedberg, Seiichiro Himeno, Xi Huang, Per A. Hultman, Ivo Iavicoli, Taiyi Jin, Robert L. Jones, Hanna L. Karlsson, Larry S. Keith, Yangho Kim, Catherine B. Klein, Michael Kleinman, David Kotelchuck, Yukinori Kusaka, Philip J. Landrigan, Per E. Leffler, Veruscka Leso, Alex Heng Li, Dominique Lison, Shan Liu, Roberto G. Lucchini, Polina Maciejczyk, Koren K. Mann, Nikki Maples-Reynolds, Michael J. Maroney, Airton C. Martins, Mary S. Matsui, Daphne B. Moffett, Lisbeth Birk Møller, M. Moiz Mumtaz, Makiko Nakano, Benoit Nemery, Koji Nogawa, Gunnar F. Nordberg, Monica Nordberg, Angelica Ortiz, Agneta Oskarsson, Elena A. Ostrakhovitch, Cezary M. Pałczyński, Natalia Pawlas, Daniela Pelclova, Maria Pesonen, K. Michael Pollard, Lothar Rink, Flavia Ruggieri, Patricia Ruiz, Harold H. Sandstead, Tiina Santonen, Kazuhiro Sato, Hiroshi Satoh, Deepak Saxena, Greet Schoeters, Bengt Sjögren, Staffan Skerfving, Donald R. Smith, Dexter W. Sullivan, Daigo Sumi, Hong Sun, Hille Suojalehto, Akiyo Tanaka, Milton Tenenbein, George D. Thurston, Francisco A. Tomei Torres, Muhammet S. Toprak, Carolyn A. Tylenda, Julian F. Tyson, Tomohiro Umemura, Margaret H. Whittaker, Jana Wolf, Wenbo Yan, Robert A. Yokel, Rudolfs K. Zalups

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5280a02c2c7fb209a75944eb8170f23
https://doi.org/10.1016/b978-0-12-823292-7.01002-0

Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans

Autor: Samuel W. Caito, Leticia Priscilla Arantes, Pan Chen, Tanara V. Peres, Michael Aschner, Félix Alexandre Antunes Soares

Publikováno v: Toxicology Research. 5:1629-1638

The influence of routine guarana (Paullinia cupana) consumption on apparent tolerance to mercury intoxication has been proposed. The present study investigated this hypothesis in Caenorhabditis elegans, a suitable experimental model for studies in to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41dd5493a38018157d702cb994819aa6
https://doi.org/10.1039/c6tx00161k

Scavengers of reactive γ-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7

Autor: James West, Samuel W. Caito, Joshua P. Fessel, Thuy T. Nguyen, L. Jackson Roberts, Michael Aschner, William E. Zackert, Shijun Zhu

Publikováno v: Aging (Albany NY)

Isoketals (IsoKs) are highly reactive γ-ketoaldehyde products of lipid peroxidation that covalently adduct lysine side chains in proteins, impairing their function. Using C. elegans as a model organism, we sought to test the hypothesis that IsoKs co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702fb915783b2080431366caa33c7336
https://pubmed.ncbi.nlm.nih.gov/27514077

Manganese Is Essential for Neuronal Health

Autor: Samuel W. Caito, Michael Aschner, Kyle J. Horning, K. Grace Tipps, Aaron B. Bowman

Publikováno v: Annual review of nutrition. 35

The understanding of manganese (Mn) biology, in particular its cellular regulation and role in neurological disease, is an area of expanding interest. Mn is an essential micronutrient that is required for the activity of a diverse set of enzymatic pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f34bc4672bca9b77c9e156dff60b95
https://pubmed.ncbi.nlm.nih.gov/25974698