Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Samuel W. CUSHMAN"'
Autor:
Candice A. Allister, Li-fen Liu, Cindy A. Lamendola, Colleen M. Craig, Samuel W. Cushman, Marc K. Hellerstein, Tracey L. McLaughlin
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 2, Pp 435-439 (2015)
Indirect evidence suggests that impaired triglyceride storage in the subcutaneous fat depot contributes to the development of insulin resistance via lipotoxicity. We directly tested this hypothesis by measuring, in vivo, TG synthesis, de novo lipogen
Externí odkaz:
https://doaj.org/article/8bb695155aea4d78afaae84528e33b52
Publikováno v:
PLoS ONE, Vol 5, Iss 4 (2010)
Externí odkaz:
https://doaj.org/article/bd37400286b44311a863875238cdae52
Publikováno v:
Journal of Lipid Research, Vol 14, Iss 6, Pp 632-642 (1973)
A rapid and flexible method has been developed for measuring cell-associated, probably intracellular, nonesterified fatty acids (CAFA) in isolated mouse adipose cells. A variety of lipolytic agents as well as various concentrations of epinephrine ele
Externí odkaz:
https://doaj.org/article/8ae90ca65579412492f34c8a3275da3c
Publikováno v:
BMC Public Health, Vol 16, Iss 1, Pp 1-12 (2016)
Abstract Background The aim of this study was to identify corresponding body mass index (BMI) and waist circumference cut-offs for equivalent levels of insulin sensitivity in a Middle Eastern immigrant population compared with native Swedes. Methods
Externí odkaz:
https://doaj.org/article/41e1478ade134d2eaf02a35eb0361d9a
Autor:
Li Fen Liu, Colleen M Craig, Lorna L Tolentino, Okmi Choi, John Morton, Homero Rivas, Samuel W Cushman, Edgar G Engleman, Tracey McLaughlin
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170728 (2017)
AIM:The physiologic mechanisms underlying the relationship between obesity and insulin resistance are not fully understood. Impaired adipocyte differentiation and localized inflammation characterize adipose tissue from obese, insulin-resistant humans
Externí odkaz:
https://doaj.org/article/32aeb8c8d27e4a08a2e885651ba423ef
Autor:
Georgeta Crivat, Vladimir A Lizunov, Caroline R Li, Karin G Stenkula, Joshua Zimmerberg, Samuel W Cushman, Leslie Pick
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e77953 (2013)
The fruit fly Drosophila melanogaster is an excellent model system for studies of genes controlling development and disease. However, its applicability to physiological systems is less clear because of metabolic differences between insects and mammal
Externí odkaz:
https://doaj.org/article/318f31fbc7834aa38afafeb7cb206ed4
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57559 (2013)
Insulin-stimulated delivery of glucose transporter-4 (GLUT4) to the plasma membrane (PM) is the hallmark of glucose metabolism. In this study we examined insulin's effects on GLUT4 organization in PM of adipose cells by direct microscopic observation
Externí odkaz:
https://doaj.org/article/5942b6b611b546c6b2ca6d2c8354c9a7
Autor:
Bernie J Daigle, Alicia Deng, Tracey McLaughlin, Samuel W Cushman, Margaret C Cam, Gerald Reaven, Philip S Tsao, Russ B Altman
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 3, p e1000718 (2010)
Although they have become a widely used experimental technique for identifying differentially expressed (DE) genes, DNA microarrays are notorious for generating noisy data. A common strategy for mitigating the effects of noise is to perform many expe
Externí odkaz:
https://doaj.org/article/ccfec585f80e4b68a51bbcf6f883b6e6
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8197 (2010)
In mammals, calories ingested in excess of those used are stored primarily as fat in adipose tissue; consistent ingestion of excess calories requires an enlargement of the adipose tissue mass. Thus, a dysfunction in adipose tissue growth may be a key
Externí odkaz:
https://doaj.org/article/3ebb294f868a4b128e59776da5035617
Autor:
Junghyo Jo, Oksana Gavrilova, Stephanie Pack, William Jou, Shawn Mullen, Anne E Sumner, Samuel W Cushman, Vipul Periwal
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 3, p e1000324 (2009)
Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Genetics and diet affect the relative contributions of these two mechanisms to the growth of adipose tissue in obesity. In this study, th
Externí odkaz:
https://doaj.org/article/89669567ec3b4f58a2e96f2f4bf1fc87