Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Samuel W Gerritz"'
High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus.
Autor:
Michael J Wichroski, Jie Fang, Betsy J Eggers, Ronald E Rose, Charles E Mazzucco, Kevin A Pokornowski, Carl J Baldick, Monique N Anthony, Craig J Dowling, Lauren E Barber, John E Leet, Brett R Beno, Samuel W Gerritz, Michele L Agler, Mark I Cockett, Daniel J Tenney
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42609 (2012)
The recent development of a Hepatitis C virus (HCV) infectious virus cell culture model system has facilitated the development of whole-virus screening assays which can be used to interrogate the entire virus life cycle. Here, we describe the develop
Externí odkaz:
https://doaj.org/article/c696c60727114ef3a6359c336e98b64f
Autor:
Carl J Baldick, Michael J Wichroski, Annapurna Pendri, Ann W Walsh, Jie Fang, Charles E Mazzucco, Kevin A Pokornowski, Ronald E Rose, Betsy J Eggers, Mayla Hsu, Weixu Zhai, Guangzhi Zhai, Samuel W Gerritz, Michael A Poss, Nicholas A Meanwell, Mark I Cockett, Daniel J Tenney
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001086 (2010)
Small molecule inhibitors of hepatitis C virus (HCV) are being developed to complement or replace treatments with pegylated interferons and ribavirin, which have poor response rates and significant side effects. Resistance to these inhibitors emerges
Externí odkaz:
https://doaj.org/article/1ee8b0be7b894e5398d932dbcf2e4866
Autor:
Kanak Raina, Chris D. Forbes, Rebecca Stronk, Jonathan P. Rappi, Kyle J. Eastman, Samuel W. Gerritz, Xinheng Yu, Hao Li, Amit Bhardwaj, Mia Forgione, Abigail Hundt, Madeline P. King, Zoe M. Posner, Allison Denny, Andrew McGovern, David E. Puleo, Ethan Garvin, Rebekka Chenard, Nilesh Zaware, James J. Mousseau, Jennifer Macaluso, Michael Martin, Kyle Bassoli, Kelli Jones, Marco Garcia, Katia Howard, Levi M. Smith, Jinshan M. Chen, Cesar A. De Leon, John Hines, Katherine J. Kayser-Bricker, Craig M. Crews
While specific cell signaling pathway inhibitors have yielded great success in oncology, directly triggering cancer cell death is one of the great drug discovery challenges facing biomedical research in the era of precision oncology. Attempts to erad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23ae61c78302824016b90ccec8643f82
https://doi.org/10.1101/2023.01.01.522436
https://doi.org/10.1101/2023.01.01.522436
Autor:
Samuel W. Gerritz
Publikováno v:
Current Opinion in Chemical Biology. 5:264-268
The host of solid supports available to the synthetic chemist adds yet another level of complexity to solid-phase synthesis. Although the selection of the optimal solid support for a specific synthetic transformation is still empirically driven, sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e243cf2ce0e30fbab5a59aab3585504b
https://doi.org/10.1016/s1367-5931(00)00201-5
https://doi.org/10.1016/s1367-5931(00)00201-5
Publikováno v:
Journal of the American Chemical Society. 122:6357-6363
A high-throughput technique for elucidating Hammett relationships on solid supports and its application to the comparison of various commercially available solid supports is reported. Specifically, we report the use of competition experiments to deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1cf60dce6ada8a8c1588a90ff8e5b67
https://doi.org/10.1021/ja9943187
https://doi.org/10.1021/ja9943187
Autor:
Samuel W. Gerritz, Andrea M. Sefler
Publikováno v:
Journal of Combinatorial Chemistry. 2:127-133
Solid-phase MAS techniques have proved to be very useful in characterizing compounds bound to resin; however, little has been reported on using NMR to characterize compounds attached to Chiron SynPhase crowns. We have used proton, carbon, and COSY sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804bb44f24d661cf75499a16ed6a0fd2
https://doi.org/10.1021/cc9900551
https://doi.org/10.1021/cc9900551
Publikováno v:
Tetrahedron Letters. 40:2227-2230
The solid phase synthesis of 1,3,5-trisubsituted pyridin-2-ones is reported via selective 1 NH- alkylation of 3-amino-5-carbomethoxy-1 H -pyridin-2-one with a solid-supported halo-acid. Coupling of an acid to solid-supported 3-aminopyridinone was fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5e9f88ff6df224b6ba8e876574c74f3
https://doi.org/10.1016/s0040-4039(98)02628-8
https://doi.org/10.1016/s0040-4039(98)02628-8
Publikováno v:
Tetrahedron Letters. 38:3377-3380
The solid-phase synthesis of trisubsituted guanidines is reported via aza-Wittig coupling of a solid-supported alkyl iminophosphorane with an aryl or alkyl isothiocyanate to generate the corresponding solid-supported carbodiimide which is then reacte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a8d9b5e518df58e6017d22a2299d79c
https://doi.org/10.1016/s0040-4039(97)00653-9
https://doi.org/10.1016/s0040-4039(97)00653-9
Autor:
Samuel W. Gerritz, Andrew T Merritt
Publikováno v:
Current Opinion in Chemical Biology. 7:305-307
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da1cb5a8a0c80dd16d8088eb45c05a85
https://doi.org/10.1016/s1367-5931(03)00063-2
https://doi.org/10.1016/s1367-5931(03)00063-2
Autor:
Akiyoshi Sawabe, Samuel W. Gerritz, Satoru Masamune, Sandra A. Filla, Norihiko Tanimoto, Takeshi Noda
Publikováno v:
Angewandte Chemie. 106:674-677
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7419a7fde79eb8e1a13059f0c99d0238
https://doi.org/10.1002/ange.19941060611
https://doi.org/10.1002/ange.19941060611