Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Samuel V. Givens"'
Autor:
Michael Budde, Michael Knoessl, Joachim Moecks, Samuel V. Givens, Walter Koehler, Gary G. Koch, Martin Scott
Publikováno v:
Journal of Biopharmaceutical Statistics. 14:415-437
Double-blind placebo-controlled clinical trials in metastatic bone disease considered counts of morbid events as the clinical outcome measure. These (recurrent) skeletal events were derived from a composite endpoint based on the necessity of medical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1037c1cdab35c72ece5323940db30651
https://doi.org/10.1081/bip-120037190
https://doi.org/10.1081/bip-120037190
Autor:
Samuel V. Givens, Olga Rutman
Publikováno v:
Journal of Biopharmaceutical Statistics. 7:605-615
Computer-assisted NDAs (CANDAs) have evolved from an instrument that provides information to regulators to also providing information to internal researchers. They are still not as useful internally during the NDA process as they will be in the futur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4333da8999d14164b15ff6f1547d2851
https://doi.org/10.1080/10543409708835210
https://doi.org/10.1080/10543409708835210
Autor:
Annette Smith, Samuel V. Givens
Publikováno v:
Drug Information Journal. 27:771-778
The measurement and assessment of laboratory data pose some special difficulties for those involved in clinical trials, particularly with respect to the definition and use of normal ranges. This paper describes a number of these problems. One importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::487edfd6cb88e791786ed3de052c722b
https://doi.org/10.1177/009286159302700320
https://doi.org/10.1177/009286159302700320
Publikováno v:
The Journal of Clinical Pharmacology. 26:48-54
The effect of single 0.25 mg, 0.75 mg, 1.5 mg, and 3.0-mg oral doses of trimoprostil and placebo on the inhibition of meal-stimulated gastric acid secretion was investigated in duodenal ulcer patients. Drug and placebo were administered in a double-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc985f7f514ebb0dfba8c8d35a36ea6
https://doi.org/10.1002/j.1552-4604.1986.tb02902.x
https://doi.org/10.1002/j.1552-4604.1986.tb02902.x
Autor:
Robert A. Levine, Bo H Min, Monte L Scheinbaum, Samuel V Givens, Hugo E Gallo-Torres, E. H. Schwartzel, Wayne A. Colburn, Robert J Wills
Publikováno v:
Clinical Pharmacology and Therapeutics. 37:113-117
A single, oral, 1.5-mg dose of trimoprostil was taken before a standard meal and a matching placebo was taken after a standard meal by 10 subjects (group A). A second group of 10 subjects took placebo before a meal and trimoprostil after the meal (gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b4bcc330b39cd124e9af3800432928
https://doi.org/10.1038/clpt.1985.21
https://doi.org/10.1038/clpt.1985.21
Autor:
Stots B Reele, Judith A Dabice, Louise M Rozik, Samuel V Givens, Cynthia A Rogers‐Phillips, Daniel G Pace
Publikováno v:
Clinical Pharmacology and Therapeutics. 44:137-144
To compare the relative merits of two different administration regimens, tyramine was administered intravenously in ascending doses to 12 healthy subjects to raise systolic blood pressure slightly more than 30 mm Hg. Six subjects received tyramine by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0427b0d5d6e05633a2f4e35931fd00ee
https://doi.org/10.1038/clpt.1988.128
https://doi.org/10.1038/clpt.1988.128
Publikováno v:
Journal of clinical pharmacology. 28(1)
The effect of oral cibenzoline on steady-state digoxin concentrations was studied in 12 healthy subjects ranging from 41 to 55 years of age. Each subject received an oral dose of 0.25 mg or 0.375 mg digoxin once daily for 27 days. On days 14 to 21, 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d400b327e98a434e4dd578edbb800aec
https://pubmed.ncbi.nlm.nih.gov/3350991
https://pubmed.ncbi.nlm.nih.gov/3350991
Autor:
M. M. C. Rees, M. Parsonnet, Robert J. Wills, Samuel V. Givens, D. M. Gibson, H. E. Gallo-Torres, F. Rubio
Publikováno v:
European journal of clinical pharmacology. 27(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4c78ccd0215d2eecacf6ff920a5b6d
https://pubmed.ncbi.nlm.nih.gov/6499906
https://pubmed.ncbi.nlm.nih.gov/6499906