Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Samuel V. Calzadilla"'
Autor:
Jinshyun R. Wu-Wong, Terry J. Opgenorth, Douglas B. Dixon, Robert J. Padley, Samuel V. Calzadilla, Jerry L. Wessale, Andrew L. Adler
Publikováno v:
Journal of Cardiovascular Pharmacology. 36:S292-S296
Endothelin (ET) receptor antagonists may be beneficial for treating several medical conditions. Human trials with various ET receptor antagonists show that these antagonists elevate the plasma immunoreactive endothelin-1 (irET-1) level, and different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5739bfb5942b4ac2eef4bb4e4a6854
https://doi.org/10.1097/00005344-200036001-00086
https://doi.org/10.1097/00005344-200036001-00086
Autor:
Chang Z. Zhu, Robert J. Padley, Terry J. Opgenorth, Samuel V. Calzadilla, Jerry L. Wessale, James J Lynch, Elizabeth A. Kowaluk, Michael F. Jarvis, Brian D. Dayton
Publikováno v:
European Journal of Pharmacology. 388:29-35
Tactile allodynia, the enhanced perception of pain in response to normally non-painful stimulation, represents a common complication of diabetic neuropathy. The activation of endothelin ET(A) receptors has been implicated in diabetes-induced reductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3596e935ee55565494c8e63eb85e86cc
https://doi.org/10.1016/s0014-2999(99)00865-1
https://doi.org/10.1016/s0014-2999(99)00865-1
Autor:
Samuel V. Calzadilla, Douglas B. Dixon, Daniel J. Hoffman, Brian D. Dayton, Hugh N. Nellans, Lisa E. Hernandez, William J. Chiou, Jinshyun R. Wu-Wong, Kennan C. Marsh, Kester Jeffrey A, T. J. Opgenorth, T. W. Von Geldern
Publikováno v:
Journal of Medicinal Chemistry. 39:982-991
The oral absorption profile of a family of azole-based ET(A)-selective antagonists has been improved through a rational series of structural modifications which were suggested by analysis of the physicochemical parameter delta log P. Comparison of ur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fafcb821dd25a65d8813bb585b940a
https://doi.org/10.1021/jm9505932
https://doi.org/10.1021/jm9505932
Publikováno v:
American Journal of Hypertension. 6:514-521
A-72517 is a potent inhibitor of human renin (IC50 = 1.0 nmol/L, pH 7.4 in plasma) and, aside from displaying modest activity against canine plasma renin (IC50 = 110 nmol/L), has been shown to be orally active in the dog and other animals. Renin inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75f95e747168460695247e27b005d98
https://doi.org/10.1093/ajh/6.6.514
https://doi.org/10.1093/ajh/6.6.514
Autor:
Glenn A. Reinhart, Bryan F. Cox, C. Thomas Lin, Samuel V. Calzadilla, Ryan M. Fryer, Hongyu Xu, Lee C. Preusser, Murali Gopalakrishnan, Yanhui Hu, Kennan C. Marsh
Publikováno v:
Journal of cardiovascular pharmacology. 44(2)
The therapeutic utility of K A T P channel opening agents (KCOs) in the treatment of overactive bladder may be limited by hypotension as a result of insufficient selectivity in vivo for bladder versus vasculature smooth muscle. Recently, we demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937af68753e97d49befc62f99a1f1e61
https://pubmed.ncbi.nlm.nih.gov/15243293
https://pubmed.ncbi.nlm.nih.gov/15243293
Autor:
Kennan C. Marsh, Terry J. Opgenorth, Brian D. Dayton, J. Ruth Wu-Wong, Thomas W. von Geldern, Martin Winn, Andrew L. Adler, Jerry L. Wessale, Eugene I. Novosad, Jae Hwan-Soo, Samuel V. Calzadilla
Publikováno v:
Clinical science (London, England : 1979). 103
Endothelins (ETs), 21-amino-acid peptides involved in the pathogenesis of various diseases, bind to ETA and ETB receptors to initiate their effects. Based on the same core structure, we have developed four small-molecule ET receptor antagonists, ABT-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2da699634e496ad2afd274f650445f
https://pubmed.ncbi.nlm.nih.gov/12193067
https://pubmed.ncbi.nlm.nih.gov/12193067
Autor:
Jerry L. Wessale, William J. Chiou, Kennan C. Marsh, Bruce G. Szczepankiewicz, Thomas W. von Geldern, Eugene I. Novosad, Lisa M. Hernández, Jinshyun R. Wu-Wong, Gang Liu, Samuel V. Calzadilla, Douglas B. Dixon, Andrew L. Adler, Brian D. Dayton, Terry J. Opgenorth
Publikováno v:
European journal of pharmacology. 366(2-3)
Endothelins, 21-amino acid peptides involved in the pathogenesis of various diseases, bind to endothelin ETA and ETB receptors to initiate their effects. Here, we characterize the pharmacology of A-216546 ([2S-(2,2-dimethylpentyl)-4S-(7-methoxy-1,3-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f790bf34bd8b8b187d83aa6ef9fb1220
https://pubmed.ncbi.nlm.nih.gov/10082200
https://pubmed.ncbi.nlm.nih.gov/10082200
Autor:
Samuel V. Calzadilla, Vered Klinghofer, Boyd Steven A, Peter J. Kovar, William R. Baker, Jerry L. Wessale, Herman H. Stein, Jennifer L. Barlow, Robert A. Mantei, Hollis D. Kleinert
Publikováno v:
Journal of cardiovascular pharmacology. 22(4)
A-74273 is a nonpeptidic, potent inhibitor of human and canine renin (IC50 = 3.1 and 43 nM, respectively, in plasma at pH 7.4) and has been shown to be orally active in dogs. To determine the hemodynamic mechanism underlying this renin inhibitor's hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1569b3a2261d5f1ca59ef52e47272e1
https://pubmed.ncbi.nlm.nih.gov/7505369
https://pubmed.ncbi.nlm.nih.gov/7505369
Publikováno v:
Cardiovascular research. 12(11)
Abrupt coronary occlusion was performed in anaesthetised, open-chest dogs with pre-occlusion arterial blood P o2 ranging from 8.0 to 10.7 kPa (60 to 80 mmHg). Ventricular fibrillation occurred in 15/19 dogs with high spontaneous heart rate (greater t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39a87211b5ea4786b702ba06cdb2973
https://pubmed.ncbi.nlm.nih.gov/750078
https://pubmed.ncbi.nlm.nih.gov/750078
Autor:
Robert D. Reynolds, Samuel V. Calzadilla, Dennis E. Drayer, William E. Burmeister, Robert J. Lee, Marcus M. Reidenberg
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 169(2)
The antiarrhythmic effects of p-hydroxy-N-(3-diethylaminopropyl)benzamide (PP), procainamide (PA), and N-acetylprocainamide (NAPA) were compared. ED50 values for PP, PA, and NAPA in the mouse chloroform arrhythmia model were not significantly differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8f48401d9a65bed08e5dcaad740e00
https://pubmed.ncbi.nlm.nih.gov/6174988
https://pubmed.ncbi.nlm.nih.gov/6174988