Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Samuel Thompson"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract While much prior work has explored the constraints on protein sequence and evolution induced by physical protein-protein interactions, the sequence-level constraints emerging from non-binding functional interactions in metabolism remain uncl
Externí odkaz:
https://doaj.org/article/758a3b3895ba497eaf578c8a4214fdc5
Autor:
Christian DeMaio BS, Rob Nayfa BS, Ty D. Reasnor BS, Jake A. Fox MD, Samuel Thompson MD, Amgad Haleem Amin MD, PhD
Publikováno v:
Foot & Ankle Orthopaedics, Vol 8 (2023)
Category: Other; Hindfoot Introduction/Purpose: The opioid epidemic in the United States has gained significant attention over the past few years. Subsequently, there have been several publications characterizing postoperative opioid consumption in p
Externí odkaz:
https://doaj.org/article/5a32cceede8f4fa8b3d2213c51e44fa5
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-17 (2022)
Abstract FOXC1 encodes a forkhead-domain transcription factor associated with several ocular disorders. Correct FOXC1 dosage is critical to normal development, yet the mechanisms controlling its expression remain unknown. Together with FOXQ1 and FOXF
Externí odkaz:
https://doaj.org/article/d8de002a61884311afd43d18ade434ed
Autor:
Atanas Radkov, Anne L Sapiro, Sebastian Flores, Corey Henderson, Hayden Saunders, Rachel Kim, Steven Massa, Samuel Thompson, Chase Mateusiak, Jacob Biboy, Ziyi Zhao, Lea M Starita, William L Hatleberg, Waldemar Vollmer, Alistair B Russell, Jean-Pierre Simorre, Spencer Anthony-Cahill, Peter Brzovic, Beth Hayes, Seemay Chou
Publikováno v:
eLife, Vol 11 (2022)
Members of the bacterial T6SS amidase effector (Tae) superfamily of toxins are delivered between competing bacteria to degrade cell wall peptidoglycan. Although Taes share a common substrate, they exhibit distinct antimicrobial potency across differe
Externí odkaz:
https://doaj.org/article/e8b6e88e62cc4ba1b7e72be730157666
Autor:
Linda M. Reis, Huban Atilla, Peter Kannu, Adele Schneider, Samuel Thompson, Tanya Bardakjian, Elena V. Semina
Publikováno v:
Genes, Vol 14, Iss 1, p 216 (2023)
Histone lysine methyltransferase and demethylase enzymes play a central role in chromatin organization and gene expression through the dynamic regulation of histone lysine methylation. Consistent with this, genes encoding for histone lysine methyltra
Externí odkaz:
https://doaj.org/article/d0e375de6ea44c35aa4b97e8b093ac9e
Publikováno v:
eLife, Vol 10 (2021)
Our ability to rationally optimize allosteric regulation is limited by incomplete knowledge of the mutations that tune allostery. Are these mutations few or abundant, structurally localized or distributed? To examine this, we conducted saturation mut
Externí odkaz:
https://doaj.org/article/3ce7063cca2b4858aca2b4f1ac587e44
Publikováno v:
eLife, Vol 9 (2020)
Protein mutational landscapes are shaped by the cellular environment, but key factors and their quantitative effects are often unknown. Here we show that Lon, a quality control protease naturally absent in common E. coli expression strains, drastical
Externí odkaz:
https://doaj.org/article/cda4130dfdc640e48cf5aaef0e23ee13
Autor:
Erik Simon-Lledó, Samuel Thompson, Andrew Yool, Adrian Flynn, Christina Pomee, John Parianos, Daniel O. B. Jones
Publikováno v:
Frontiers in Marine Science, Vol 6 (2019)
We report on preliminary observations of the abyssal megafauna communities in the exclusive economic zone of Kiribati, a huge abyssal area with few previous studies. These observations also provide useful context for marine minerals exploration withi
Externí odkaz:
https://doaj.org/article/af8169c7b42f4c5b99a43f4bd5e657af
Autor:
David Mavor, Kyle Barlow, Samuel Thompson, Benjamin A Barad, Alain R Bonny, Clinton L Cario, Garrett Gaskins, Zairan Liu, Laura Deming, Seth D Axen, Elena Caceres, Weilin Chen, Adolfo Cuesta, Rachel E Gate, Evan M Green, Kaitlin R Hulce, Weiyue Ji, Lillian R Kenner, Bruk Mensa, Leanna S Morinishi, Steven M Moss, Marco Mravic, Ryan K Muir, Stefan Niekamp, Chimno I Nnadi, Eugene Palovcak, Erin M Poss, Tyler D Ross, Eugenia C Salcedo, Stephanie K See, Meena Subramaniam, Allison W Wong, Jennifer Li, Kurt S Thorn, Shane Ó Conchúir, Benjamin P Roscoe, Eric D Chow, Joseph L DeRisi, Tanja Kortemme, Daniel N Bolon, James S Fraser
Publikováno v:
eLife, Vol 5 (2016)
Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance
Externí odkaz:
https://doaj.org/article/f3e8373dbc7b4012a1c82425c9fb49fb
Autor:
Deepti Bal, Atif Iqbal Ahmed Shaikh, Murali Rayani, Sanjith Aaron, Viji Samuel Thompson, John Jose, Jesu Krupa, Rohit Ninan Benjamin, Joanne Lydia Rajkumar, Appaswamy Thirumal Prabhakar
Publikováno v:
Journal of the Association of Physicians of India. 70:52-56
Background: Cryptogenic strokes are common in young adults. Patent foramen ovale (PFO) is an important cause of cryptogenic ischemic strokes. Transcranial Doppler (TCD) with bubble contrast is a noninvasive bedside tool in screening for PFO and other