Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Samuel T. Slocum"'
Autor:
Yi-Yuan Lee, Mustafa Guler, Desnor N. Chigumba, Shen Wang, Neel Mittal, Cameron Miller, Benjamin Krummenacher, Haodong Liu, Liu Cao, Aditya Kannan, Keshav Narayan, Samuel T. Slocum, Bryan L. Roth, Alexey Gurevich, Bahar Behsaz, Roland D. Kersten, Hosein Mohimani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Recent analyses of public microbial genomes have found over a million biosynthetic gene clusters, the natural products of the majority of which remain unknown. Additionally, GNPS harbors billions of mass spectra of natural products without k
Externí odkaz:
https://doaj.org/article/d0cd311036a049e799043f3d3049ff80
Autor:
Brian E. Krumm, Jeffrey F. DiBerto, Reid H. J. Olsen, Hye Jin Kang, Samuel T. Slocum, Shicheng Zhang, Ryan T. Strachan, Xi-Ping Huang, Lauren M. Slosky, Anthony B. Pinkerton, Lawrence S. Barak, Marc G. Caron, Terry Kenakin, Jonathan F. Fay, Bryan L. Roth
Publikováno v:
Biochemistry. 62:1233-1248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e46ba96106037966aa36314ed803bd6d
https://doi.org/10.1021/acs.biochem.3c00029
https://doi.org/10.1021/acs.biochem.3c00029
Autor:
Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar
Publikováno v:
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Externí odkaz:
https://doaj.org/article/dc31183697a3454e95268139bbe3d9fd
Autor:
Anat Levit Kaplan, Danielle N. Confair, Kuglae Kim, Ximena Barros-Álvarez, Ramona M. Rodriguiz, Ying Yang, Oh Sang Kweon, Tao Che, John D. McCorvy, David N. Kamber, James P. Phelan, Luan Carvalho Martins, Vladimir M. Pogorelov, Jeffrey F. DiBerto, Samuel T. Slocum, Xi-Ping Huang, Jain Manish Kumar, Michael J. Robertson, Ouliana Panova, Alpay B. Seven, Autumn Q. Wetsel, William C. Wetsel, John J. Irwin, Georgios Skiniotis, Brian K. Shoichet, Bryan L. Roth, Jonathan A. Ellman
Publikováno v:
Nature. 610:582-591
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baa77bd0c4ea2800539996a89d21473e
https://doi.org/10.1038/s41586-022-05258-z
https://doi.org/10.1038/s41586-022-05258-z
Publikováno v:
ACS Chemical Neuroscience. 13:2386-2398
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51ff15594835cffc8588f86706e76e9e
https://doi.org/10.1021/acschemneuro.1c00815
https://doi.org/10.1021/acschemneuro.1c00815
Publikováno v:
Journal of Neurochemistry. 162:24-38
A confluence of factors has renewed interest in the scientific understanding and translational potential of psychedelic drugs such as lysergic acid diethylamide (LSD), mescaline, and psilocybin: the desire for additional approaches to mental health c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafac5a4ce8b95de5f352849ddaf044f
https://doi.org/10.1111/jnc.15540
https://doi.org/10.1111/jnc.15540
Autor:
Brian E. Krumm, Jeffrey F. DiBerto, Reid H. J. Olsen, Hye Jin Kang, Samuel T. Slocum, Shicheng Zhang, Ryan T. Strachan, Lauren M. Slosky, Anthony B. Pinkerton, Lawrence S. Barak, Marc G. Caron, Terry Kenakin, Jonathan F. Fay, Bryan L. Roth
SUMMARYThe NTSR1 neurotensin receptor (NTSR1) is a G protein coupled receptor (GPCR) found in the brain and peripheral tissues with neurotensin (NTS) being its endogenous peptide ligand. In the brain, NTS modulates dopamine neuronal activity, induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7f8f9a1b8e405f18eeb9bd5e4602a8f
https://doi.org/10.1101/2022.12.26.521971
https://doi.org/10.1101/2022.12.26.521971
Autor:
Samuel T. Slocum, Yongfeng Liu, Bryan L. Roth, Jian Jin, Brian E. Krumm, Brian J. Bender, Reid H.J. Olsen, Hye Jin Kang, Justin G. English, Isha Singh, Jing Liu, Lily Yeh Jan, Wenlei Ye, Brian K. Shoichet, Xi Ping Huang, Byron W. Hayes, Can Cao, John D. McCorvy, Jonathan F. Fay, Katherine Lansu, Soman N. Abraham, Shicheng Zhang, Chengwei Zhang, Wesley K. Kroeze, Kuglae Kim, He Chen, Ryan H. Gumpper, Jeffrey F. DiBerto, Joel Karpiak
Publikováno v:
Nature
Nature, vol 600, iss 7887
Nature, vol 600, iss 7887
The MRGPRX family of receptors (MRGPRX1–4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently1. Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e74bb609d8bd744fc782cf9ab54a3d
https://doi.org/10.1038/s41586-021-04126-6
https://doi.org/10.1038/s41586-021-04126-6
Autor:
Bronwyn M. Kivell, Shainnel O. Eans, Abdullah Allaoa, András Váradi, Lisa L. Wilson, Gavril W. Pasternak, Rajendra Uprety, Andrew C. Kruegel, John E. Pintar, Xiaohai Li, Samuel T. Slocum, Takeshi Irie, Jay P. McLaughlin, Brittany Scouller, Amy F. Alder, Michael D. Cameron, Sanjay Kalra, Ying-Xian Pan, Amanda Hunkele, Susruta Majumdar, Michael Ansonoff, Valerie Le Rouzic, Dalibor Sames, Soumen Chakraborty, Jin Xu
Publikováno v:
J Med Chem
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of natural products chemistry, chemical synthesis, and pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c5e470bfb54471841442c42450dcbe
https://doi.org/10.1021/acs.jmedchem.1c01111
https://doi.org/10.1021/acs.jmedchem.1c01111
Autor:
Abdelfattah Faouzi, Haoqing Wang, Saheem A. Zaidi, Jeffrey F. DiBerto, Tao Che, Qianhui Qu, Michael J. Robertson, Manish K. Madasu, Amal El Daibani, Balazs R. Varga, Tiffany Zhang, Claudia Ruiz, Shan Liu, Jin Xu, Kevin Appourchaux, Samuel T. Slocum, Shainnel O. Eans, Michael D. Cameron, Ream Al-Hasani, Ying Xian Pan, Bryan L. Roth, Jay P. McLaughlin, Georgios Skiniotis, Vsevolod Katritch, Brian K. Kobilka, Susruta Majumdar
Publikováno v:
Nature.
Mu opioid receptor (µOR) agonists like fentanyl have long been used for pain management, but are considered a major public health concern due to their adverse side effects, including lethal overdose.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143f7b494fdbc9f2a3c16eb8287e1d82
https://pubmed.ncbi.nlm.nih.gov/36450356
https://pubmed.ncbi.nlm.nih.gov/36450356