Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Samuel T. Robinson"'
Autor:
Aranzazu Villasante, Samuel T. Robinson, Andrew R. Cohen, Roberta Lock, X. Edward Guo, Gordana Vunjak-Novakovic
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
For decades, fetal bovine serum (FBS) has been used routinely for culturing many cell types, based on its empirically demonstrated effects on cell growth, and the lack of suitable non-xenogeneic alternatives. The FBS-based culture media do not repres
Externí odkaz:
https://doaj.org/article/bafff20ad3d24e35a3008ff4ce405b5e
Publikováno v:
Bone
Sclerostin antibody romosozumab (EVENITY™, romosozumab-aqqg) has a dual mechanism of action on bone, increasing bone formation and decreasing bone resorption, leading to increases in bone mass and strength, and a decreased risk of fracture, and has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe69211009a49d822c330704c2619f0b
https://europepmc.org/articles/PMC8217200/
https://europepmc.org/articles/PMC8217200/
Autor:
Jonathan Bernhard, Kelsey M. Kennedy, X. Edward Guo, Jeffrey M. Gimble, Keith Yeager, Brandon Zimmerman, Mandi J. Lopez, Sidney B. Eisig, Johnathan Ng, Catherine Takawira, David J. Chen, Samuel T. Robinson, Krista M. Durney, Josephine Y. Wu, Courtney A. Shaeffer, Olaia F. Vila, Gordana Vunjak-Novakovic, Gerard A. Ateshian
Publikováno v:
Science Translational Medicine. 12
Joint disorders can be detrimental to quality of life. There is an unmet need for precise functional reconstruction of native-like cartilage and bone tissues in the craniofacial space and particularly for the temporomandibular joint (TMJ). Current su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d79dfe89a63384b673d05e9cb574e1
https://doi.org/10.1126/scitranslmed.abb6683
https://doi.org/10.1126/scitranslmed.abb6683
Publikováno v:
Connect Tissue Res
PURPOSE: The osteocyte is considered the major mechanosensor in bone, capable of detecting forces at a cellular level to coordinate bone formation and resorption. The pathology of age-related bone loss, a hallmark of osteoporosis, is attributed in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a282b849a9f6200af51766f59c5c71a
https://pubmed.ncbi.nlm.nih.gov/31931640
https://pubmed.ncbi.nlm.nih.gov/31931640
Purpose: The osteocyte is considered the major mechanosensor in bone, capable of detecting forces at a cellular level to coordinate bone formation and resorption. The pathology of age-related bone loss, a hallmark of osteoporosis, is attributed in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fc468efb25f2c3f5a2ba521a98c21e
Publikováno v:
Bone
Intermittent injections of parathyroid hormone (PTH) and mechanical loading are both known to effect a net increase in bone mass. Fundamentally, bone metabolism can be divided into modeling (uncoupled formation or resorption) and remodeling (subseque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68b24739d681af0760454704da81fc8
https://doi.org/10.1016/j.bone.2021.116171
https://doi.org/10.1016/j.bone.2021.116171
Autor:
X. Edward Guo, Bin Zhou, Jonathan Bernhard, Yiyong Wei, Johnathan Ng, Aonnicha Burapachaisri, Samuel T. Robinson, Gordana Vunjak-Novakovic
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2556-2561
Standard isotropic culture fails to recapitulate the spatiotemporal gradients present during native development. Cartilage grown from human mesenchymal stem cells (hMSCs) is poorly organized and unstable in vivo. We report that human cartilage with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147038a09e63cf5c0f6110aad709b466
https://doi.org/10.1073/pnas.1611771114
https://doi.org/10.1073/pnas.1611771114
Autor:
Rachel L. Sattler, Gehua Zhen, Genevieve N. Brown, Lance C. Kam, Samuel T. Robinson, Andrea E. Morrell, Lynda F. Bonewald, X. Edward Guo, Xu Cao, Andrew D. Baik, Weiyang Jin
Publikováno v:
Bone Research, Vol 6, Iss 1, Pp 1-11 (2018)
Bone Research
Bone Research
The vast osteocytic network is believed to orchestrate bone metabolic activity in response to mechanical stimuli through production of sclerostin, RANKL, and osteoprotegerin (OPG). However, the mechanisms of osteocyte mechanotransduction remain poorl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c471b5fdc9d12db885b7229d553e14e8
https://doi.org/10.1038/s41413-018-0007-x
https://doi.org/10.1038/s41413-018-0007-x
Autor:
Manami Hiraiwa, Hitoshi Kurose, Yuki Onishi, Takashi Kanayama, Hiroyuki Fujita, Michio Nakaya, Tetsuhiro Horie, Kakeru Ozaki, Yukio Yoneda, X. Edward Guo, Gyujin Park, Takashi Iezaki, Takeshi Takarada, Kazuya Fukasawa, Katsuyuki Kaneda, Eiichi Hinoi, Yuka Kitaguchi, Samuel T. Robinson
Publikováno v:
Development.
Extracellular signal-regulated kinase 5 (Erk5) belongs to the mitogen-activated protein kinase (MAPK) family. Following its phosphorylation by MAPK/Erk kinase-5 (Mek5), Erk5 modulates several signaling pathways in a number of cell types. In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be17a0b1f06550d498c9e01e21972e04
https://doi.org/10.1242/dev.164004
https://doi.org/10.1242/dev.164004