Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Samuel Sperry"'
Autor:
Kevin R. Webster, Siegfried H. Reich, Justin T. Ernst, Paul A. Sprengeler, Chinh Tran, Theodore Michels, Garrick K. Packard, Christian Nilewski, Alan Xiang, Samuel Sperry, Jeff Clarine, Andres Nevarez, Christopher J. Wegerski, Adina Gerson-Gurwitz, Gary G. Chiang, Jocelyn Staunton, Ana Parra, Eric Sung, Haleigh Howard, Maria Barrera, Joan Chen, Sarah Fish, Nathan P. Young, Boreth Eam, Peggy A. Thompson
The PI3K/AKT/mTOR pathway is often activated in lymphoma through alterations in PI3K, PTEN, and B-cell receptor signaling, leading to dysregulation of eIF4A (through its regulators, eIF4B, eIF4G, and PDCD4) and the eIF4F complex. Activation of eIF4F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1650a320f50adfe95d94d63fa8b72d9e
https://doi.org/10.1158/1535-7163.c.6542892.v1
https://doi.org/10.1158/1535-7163.c.6542892.v1
Autor:
Kevin R. Webster, Siegfried H. Reich, Justin T. Ernst, Paul A. Sprengeler, Chinh Tran, Theodore Michels, Garrick K. Packard, Christian Nilewski, Alan Xiang, Samuel Sperry, Jeff Clarine, Andres Nevarez, Christopher J. Wegerski, Adina Gerson-Gurwitz, Gary G. Chiang, Jocelyn Staunton, Ana Parra, Eric Sung, Haleigh Howard, Maria Barrera, Joan Chen, Sarah Fish, Nathan P. Young, Boreth Eam, Peggy A. Thompson
Tables S1-S3, Figures S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b76301f84d3ad65de199ac1ded585c
https://doi.org/10.1158/1535-7163.22521054.v1
https://doi.org/10.1158/1535-7163.22521054.v1
Autor:
Haleigh Howard, Eric Sung, Samuel Sperry, Christopher J. Wegerski, Tran Chinh Viet, Adina Gerson-Gurwitz, Gary G. Chiang, Garrick Packard, Andres Nevarez, Paul A. Sprengeler, Joan Chen, Jocelyn Staunton, Kevin R. Webster, Maria Barrera, Reich Siegfried Heinz, Ana Parra, Nathan P Young, Alan Xiang, Justin T. Ernst, Sarah Fish, Theodore Michels, Peggy A. Thompson, Christian Nilewski, Jeff Clarine, Boreth Eam
Publikováno v:
Molecular Cancer Therapeutics. 20:26-36
The PI3K/AKT/mTOR pathway is often activated in lymphoma through alterations in PI3K, PTEN, and B-cell receptor signaling, leading to dysregulation of eIF4A (through its regulators, eIF4B, eIF4G, and PDCD4) and the eIF4F complex. Activation of eIF4F
Autor:
Nathan P Young, Paul A. Sprengeler, Christopher J. Wegerski, Samuel Sperry, Tran Chinh Viet, Andres Nevarez, Kevin R. Webster, Jocelyn Staunton, Haleigh Howard, Gary G. Chiang, Jim R Appleman, Alan Xiang, Theodore Michels, Reich Siegfried Heinz, Jolene Molter, Garrick Packard, Jeff Clarine, Christian Nilewski, Sarah Fish, Justin T. Ernst, Peggy A. Thompson, Boreth Eam, Joan Chen
Publikováno v:
Journal of medicinal chemistry. 63(11)
Dysregulation of protein translation is a key driver for the pathogenesis of many cancers. Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a critical component of the eIF4F complex, which regulates cap-dependent pr
Autor:
Nathan P. Young, Gary G. Chiang, Andres Nevarez, Joan Chen, Tran Chinh Viet, Reich Siegfried Heinz, Theodore Michels, Eric Sung, Haleigh Howard, Christopher J. Wegerski, Ana Parra, Gregory S. Parker, Boreth Eam, Alan Xiang, Samuel Sperry, Jocelyn Staunton, Maria Barrera, Christian Nilewski, Kevin R. Webster, Garrick Packard, Sarah Fish, Jeff Clarine, Paul A. Sprengeler, Peggy A. Thompson, Ivy Nj Hung, Justin T. Ernst
Publikováno v:
Cancer Research. 78:DDT02-05
eFT226: A Selective and Highly Potent Inhibitor of Eukaryotic Initiation Factor 4A (eIF4A), a Novel Approach for the Treatment of Cancer Siegfried H Reich, Peggy A Thompson, Justin T Ernst, Boreth Eam, Nathan P Young, Sarah Fish, Joan Chen, Maria Bar
Autor:
Christian Nilewski, Andres Nevarez, Sarah Fish, Boreth Eam, Alan X. Xiang, Paul A. Sprengeler, Peggy A. Thompson, Jeff Clarine, Garrick Kenneth Packard, Theodore Michels, Reich Siegfried Heinz, Christopher J. Wegerski, Justin T. Ernst, Samuel Sperry
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 47:128111
Flavaglines such as silvestrol (1) and rocaglamide (2) constitute an interesting class of natural products with promising anticancer activities. Their mode of action is based on inhibition of eukaryotic initiation factor 4A (eIF4A) dependent translat
Autor:
Joan Chen, Jeff Clarine, Craig R. Stumpf, Paul A. Sprengeler, Christopher J. Wegerski, Michels Theodore, Garrick Kenneth Packard, Christian Nilewski, Jocelyn Staunton, Eric Sung, Kaveri Urklalan, Alan Xiang, Takasuke Mukaiyama, Reich Siegfried Heinz, Ivy Nj Hung, Justin T. Ernst, Kevin R. Webster, Gary G. Chiang, Gregory S. Parker, Andreas Nevarez, Peggy A. Thompson, Samuel Sperry, Maria Barrera, Ana Parra
Publikováno v:
Molecular Cancer Research. 18:B33-B33
Aberrant protein translation plays a role in the pathogenesis of multiple solid tumors and hematologic malignancies. The translation initiation factor eIF4E is essential for the translation of m7G-capped mRNA and is a key point of convergence for sev
Abstract B133: eFT226, a first in class inhibitor of eIF4A1, targets FGFR1/2 and HER2 driven cancers
Autor:
Samuel Sperry, Nathan P Young, Gregory S. Parker, Adina Gerson-Gurwitz, Reich Siegfried Heinz, Boreth Eam, Maria Barrera, Gary G. Chiang, Vikas K Goel, Eric Sung, Craig R. Stumpf, Joan Chen, Christopher J. Wegerski, Kevin R. Webster, Jocelyn Staunton, Peggy A. Thompson, Sarah Fish
Publikováno v:
Molecular Cancer Therapeutics. 18:B133-B133
Background: Mutations or amplifications affecting receptor tyrosine kinases (RTKs) activate the RAS/MAPK and PI3K/AKT signaling pathways thereby promoting cancer cell proliferation and survival. Oncoprotein expression is tightly controlled at the lev
Autor:
Joan Chen, Melissa Neal, Katti Jessen, Gregory S. Parker, Reich Siegfried Heinz, Michael B. Shaghafi, Edward Z. R. Han, Ivy Nj Hung, Justin T. Ernst, James R. Appleman, Tran Chinh Viet, Qing Han, Douglas E. Murphy, Craig R. Stumpf, Christopher J. Wegerski, Vera Huang, Jolene Molter, Paul A. Sprengeler, Peggy A. Thompson, Jocelyn Staunton, Gary G. Chiang, Vikas K Goel, Jeff Clarine, Samuel Sperry, Boreth Eam, Kevin R. Webster, Adriana L. Jemison, Stephen E. Webber, Hong Zheng
Publikováno v:
Journal of medicinal chemistry. 61(8)
Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated protein kinase interacting kinases (MNK)1/2 are key regulators of mRNA translation integrating signals from oncogenic and immune signaling pathways through phosph
Autor:
Dean Stamos, Michael Liu, Beth Fleck, Lance Goulet, Weichao Chen, Harmon J. Zuccola, Phillip W. Snyder, Dao Tran, Peggy Chiang, James Reynolds, Azin Nezami, Samuel Sperry, Khisal Ahmed Alvi, Alcacio Timothy, Lisa Woody, William Kargo, Amy Turnbull, Timothy Neubert, Justin T. Ernst
Publikováno v:
Journal of Medicinal Chemistry. 57:3382-3400
A structure-based drug design strategy was used to optimize a novel benzolactam series of HSP90α/β inhibitors to achieve >1000-fold selectivity versus the HSP90 endoplasmic reticulum and mitochondrial isoforms (GRP94 and TRAP1, respectively). Selec