Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Samuel Schmitz"'
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The human adaptive immune response enables the targeting of epitopes on pathogens with high specificity. Infection with a pathogen induces somatic hyper-mutation and B-cell selection processes that govern the shape and diversity of the antibody seque
Externí odkaz:
https://doaj.org/article/55d70e278c44490795e6dde18e581202
Autor:
Cinque Soto, Jessica A. Finn, Jordan R. Willis, Samuel B. Day, Robert S. Sinkovits, Taylor Jones, Samuel Schmitz, Jens Meiler, Andre Branchizio, James E. Crowe
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-7 (2020)
Abstract Background Recent advances in DNA sequencing technologies have enabled significant leaps in capacity to generate large volumes of DNA sequence data, which has spurred a rapid growth in the use of bioinformatics as a means of interrogating an
Externí odkaz:
https://doaj.org/article/edd5c95dc07b4be798f44bcf7e346469
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 1, p e1008568 (2021)
Computational protein design has the ambitious goal of crafting novel proteins that address challenges in biology and medicine. To overcome these challenges, the computational protein modeling suite Rosetta has been tailored to address various protei
Externí odkaz:
https://doaj.org/article/c670d4ef8cf84908876a0d0db0c5af43
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The antibody (Ab) germline gene rearrangement of variable (V), diversity (D), and joining (J) gene segments, as well as somatic hypermutation, give rise to the human Ab variable gene sequence repertoire. It is common to characterize single nucleotide
Externí odkaz:
https://doaj.org/article/adad5970d6da468f88a9148d70bb3721
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 6, p e1005600 (2017)
Computational protein design (CPD) is a powerful technique to engineer existing proteins or to design novel ones that display desired properties. Rosetta is a software suite including algorithms for computational modeling and analysis of protein stru
Externí odkaz:
https://doaj.org/article/e3ee4b9dbca547e89bb740373759321d
Autor:
Elisabeth Silberhorn, Uwe Schwartz, Patrick Löffler, Samuel Schmitz, Anne Symelka, Tania de Koning-Ward, Rainer Merkl, Gernot Längst
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006080 (2016)
The packaging and organization of genomic DNA into chromatin represents an additional regulatory layer of gene expression, with specific nucleosome positions that restrict the accessibility of regulatory DNA elements. The mechanisms that position nuc
Externí odkaz:
https://doaj.org/article/ff1bd278a9044d38bbed43616969f964
Publikováno v:
Proteins
Antibody-antigen co-crystal structures are a valuable resource for the fundamental understanding of antibody-mediated immunity. Determination of structures with antibodies in complex with their antigens, however, is a laborious task without guarantee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439abb6d8ab5238e1e9a88274891e031
https://doi.org/10.1002/prot.26166
https://doi.org/10.1002/prot.26166
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 1, p e1008568 (2021)
PLoS Computational Biology
PLoS Computational Biology
Computational protein design has the ambitious goal of crafting novel proteins that address challenges in biology and medicine. To overcome these challenges, the computational protein modeling suite Rosetta has been tailored to address various protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21a6c998fdb3e5b5ebdebe6701c6008
https://doaj.org/article/c670d4ef8cf84908876a0d0db0c5af43
https://doaj.org/article/c670d4ef8cf84908876a0d0db0c5af43
Autor:
Robert Stein, Antje Körner, Kathrin Landgraf, Rami Abou Jamra, Jürgen Kratzsch, Franziska Voigtmann, Jens Meiler, Annette G. Beck-Sickinger, Samuel Schmitz, Matthias Blüher, Philipp Wolf, Wieland Kiess
Publikováno v:
Metabolism 116:154438 (2021)
Background Deficiency in the leptin-leptin receptor (LEPR) axis leads to severe, and potentially treatable, obesity in humans. To guide clinical decision-making, the functional relevance of variants in the LEPR gene needs to be carefully investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8685480e702291d75ffd686883e1ab51
https://pubmed.ncbi.nlm.nih.gov/33221380
https://pubmed.ncbi.nlm.nih.gov/33221380
Autor:
James E. Crowe, Taylor Jones, Jessica A. Finn, Jens Meiler, Robert S. Sinkovits, Cinque Soto, Jordan R. Willis, Samuel Schmitz, Samuel Day, Andre Branchizio
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-7 (2020)
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-7 (2020)
Background Recent advances in DNA sequencing technologies have enabled significant leaps in capacity to generate large volumes of DNA sequence data, which has spurred a rapid growth in the use of bioinformatics as a means of interrogating antibody va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af85a8fca832a58bad9c6779c961ed9
http://europepmc.org/articles/PMC7364545
http://europepmc.org/articles/PMC7364545