Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Samuel Schäfer"'
Autor:
Samuel Schäfer, Martin Smelik, Oleg Sysoev, Yelin Zhao, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Holger Heyn, Antonio Julia, István A. Kovács, Joseph Loscalzo, Sara Marsal, Huan Zhang, Xinxiu Li, Danuta Gawel, Hui Wang, Mikael Benson
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-24 (2024)
Abstract Background Ineffective drug treatment is a major problem for many patients with immune-mediated inflammatory diseases (IMIDs). Important reasons are the lack of systematic solutions for drug prioritisation and repurposing based on characteri
Externí odkaz:
https://doaj.org/article/cc1c6e30e6e14966a03d083a086f0b98
A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets
Autor:
Xinxiu Li, Eun Jung Lee, Sandra Lilja, Joseph Loscalzo, Samuel Schäfer, Martin Smelik, Maria Regina Strobl, Oleg Sysoev, Hui Wang, Huan Zhang, Yelin Zhao, Danuta R. Gawel, Barbara Bohle, Mikael Benson
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-21 (2022)
Abstract Background Medical digital twins are computational disease models for drug discovery and treatment. Unresolved problems include how to organize and prioritize between disease-associated changes in digital twins, on cellulome- and genome-wide
Externí odkaz:
https://doaj.org/article/bff40798a944430ca9b713b2d1f1f0ae
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 16, Iss 1, Pp 1-8 (2020)
Abstract Background Non-communicable diseases, such as allergies, are influenced by both genetic and epigenetic factors. Perinatal determinants conceivably modify the epigenetic makeup of the developing fetal immune system preventing or predisposing
Externí odkaz:
https://doaj.org/article/de7ca89d500e48ae934dd896710ab017
Autor:
Bergthor Björnsson, Carl Borrebaeck, Nils Elander, Thomas Gasslander, Danuta R. Gawel, Mika Gustafsson, Rebecka Jörnsten, Eun Jung Lee, Xinxiu Li, Sandra Lilja, David Martínez-Enguita, Andreas Matussek, Per Sandström, Samuel Schäfer, Margaretha Stenmarker, X. F. Sun, Oleg Sysoev, Huan Zhang, Mikael Benson, on behalf of the Swedish Digital Twin Consortium
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-4 (2019)
Abstract Personalized medicine requires the integration and processing of vast amounts of data. Here, we propose a solution to this challenge that is based on constructing Digital Twins. These are high-resolution models of individual patients that ar
Externí odkaz:
https://doaj.org/article/813cc408ddb94ef6ad9e11849ee4ab05
Autor:
Danuta R. Gawel, Eun Jung Lee, Xinxiu Li, Sandra Lilja, Andreas Matussek, Samuel Schäfer, Renate Slind Olsen, Margaretha Stenmarker, Huan Zhang, Mikael Benson
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Screening programs for colorectal cancer (CRC) often rely on detection of blood in stools, which is unspecific and leads to a large number of colonoscopies of healthy subjects. Painstaking research has led to the identification of a large nu
Externí odkaz:
https://doaj.org/article/ab9bb67a288e45d0bb73b6b76a175059
Autor:
Danuta R. Gawel, Jordi Serra-Musach, Sandra Lilja, Jesper Aagesen, Alex Arenas, Bengt Asking, Malin Bengnér, Janne Björkander, Sophie Biggs, Jan Ernerudh, Henrik Hjortswang, Jan-Erik Karlsson, Mattias Köpsen, Eun Jung Lee, Antonio Lentini, Xinxiu Li, Mattias Magnusson, David Martínez-Enguita, Andreas Matussek, Colm E. Nestor, Samuel Schäfer, Oliver Seifert, Ceylan Sonmez, Henrik Stjernman, Andreas Tjärnberg, Simon Wu, Karin Åkesson, Alex K. Shalek, Margaretha Stenmarker, Huan Zhang, Mika Gustafsson, Mikael Benson
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-25 (2019)
Abstract Background Genomic medicine has paved the way for identifying biomarkers and therapeutically actionable targets for complex diseases, but is complicated by the involvement of thousands of variably expressed genes across multiple cell types.
Externí odkaz:
https://doaj.org/article/df9e574b19784a248beeb061ae47db7f
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0252215 (2021)
Asthma is the most common non-communicable pulmonary condition, affecting prepubertal boys more often than girls. This study explored how maternal and perinatal risk factors are linked to poorly controlled childhood asthma in a sex dependent manner.
Externí odkaz:
https://doaj.org/article/f29b80987b2f416087162ba52e038c37
Autor:
Xinxiu Li, Eun Jung Lee, Danuta R. Gawel, Sandra Lilja, Samuel Schäfer, Huan Zhang, Mikael Benson
Publikováno v:
Journal of Immunology Research, Vol 2020 (2020)
Background. Unbiased studies using different genome-wide methods have identified a great number of candidate biomarkers for diagnosis and treatment response in pediatric ulcerative colitis (UC). However, clinical translation has been proven difficult
Externí odkaz:
https://doaj.org/article/7f46128d37064a5cb98f40244e250582
Autor:
Danuta R. Gawel, Jordi Serra-Musach, Sandra Lilja, Jesper Aagesen, Alex Arenas, Bengt Asking, Malin Bengnér, Janne Björkander, Sophie Biggs, Jan Ernerudh, Henrik Hjortswang, Jan-Erik Karlsson, Mattias Köpsen, Eun Jung Lee, Antonio Lentini, Xinxiu Li, Mattias Magnusson, David Martínez-Enguita, Andreas Matussek, Colm E. Nestor, Samuel Schäfer, Oliver Seifert, Ceylan Sonmez, Henrik Stjernman, Andreas Tjärnberg, Simon Wu, Karin Åkesson, Alex K. Shalek, Margaretha Stenmarker, Huan Zhang, Mika Gustafsson, Mikael Benson
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/1bebcba2f7344d23bc047b7d6fbb6f8c
Autor:
Eun Jung Lee, Sandra Lilja, Mikael Benson, Oleg Sysoev, Huan Zhang, Xinxiu Li, Danuta R. Gawel, Samuel Schäfer
Publikováno v:
Rhinology journal. 58:360-367
Background: Identification of clinically useful biomarkers for Nasal Polyposis in chronic rhinosinusitis (CRSwNP) has proven dif-ficult. We analyzed gene expression profiling data to find explanations for this. Methods: We analyzed mRNA expression pr