Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Samuel Sances"'
Autor:
Samuel Sances, Ritchie Ho, Gad Vatine, Dylan West, Alex Laperle, Amanda Meyer, Marlesa Godoy, Paul S. Kay, Berhan Mandefro, Seigo Hatata, Chris Hinojosa, Norman Wen, Dhruv Sareen, Geraldine A. Hamilton, Clive N. Svendsen
Publikováno v:
Stem Cell Reports, Vol 10, Iss 4, Pp 1222-1236 (2018)
Summary: Human stem cell-derived models of development and neurodegenerative diseases are challenged by cellular immaturity in vitro. Microengineered organ-on-chip (or Organ-Chip) systems are designed to emulate microvolume cytoarchitecture and enabl
Externí odkaz:
https://doaj.org/article/e1c4fcc300f543d9b59a13d1f73ed7bf
Publikováno v:
Lab on a Chip. 22:4246-4255
Engineered microfluidic organ-chips enable increased cellular diversity and function of human stem cell-derived tissues growniin vitro/i. These three dimensional (3D) cultures, however, are met with unique challenges in visualization and quantificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bd850af0fe6a2f89347900a271f10c
https://doi.org/10.1039/d2lc00116k
https://doi.org/10.1039/d2lc00116k
Publikováno v:
Cell Stem Cell
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease modeling and have unlocked new possibilities for understanding the mechanisms governing human biology, physiology, and genetics. However, hiPSC-derivatives have tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca3bc0d1c394b510333eff83c196003
https://doi.org/10.1016/j.stem.2020.02.011
https://doi.org/10.1016/j.stem.2020.02.011
Autor:
Veronica J. Garcia, Laperle Alexander, Zhan Shu, Matthew Jones, Maria G. Banuelos, K. M. Roxas, Clive N. Svendsen, Pablo Avalos, M. Tagliati, Samuel Sances, Victoria Dardov, Ritchie Ho, Ramachandran Murali, J. E. Van Eyk, Yucer Nur, A. N. Fulton, N. T. Maidment, D. West
Publikováno v:
Nature Medicine. 26:289-299
Young-onset Parkinson's disease (YOPD), defined by onset at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8acea9615c428aeb8b01e19fc0e2c7a7
https://doi.org/10.1038/s41591-019-0739-1
https://doi.org/10.1038/s41591-019-0739-1
Autor:
Leyla Amirifar, Amir Shamloo, Rohollah Nasiri, Natan Roberto de Barros, Ze Zhong Wang, Bige Deniz Unluturk, Alberto Libanori, Oleksandr Ievglevskyi, Sibel Emir Diltemiz, Samuel Sances, Ilangko Balasingham, Stephanie K. Seidlits, Nureddin Ashammakhi
Publikováno v:
Biomaterials. 285
Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to the development of organ-on-a-chip devices that can reproduce key functions of various organs. Such platforms promise to provide novel insights into variou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cd42f26c0e63f0d814e274b32abbdc
https://pubmed.ncbi.nlm.nih.gov/35533441
https://pubmed.ncbi.nlm.nih.gov/35533441
Autor:
Ritchie Ho, Samuel Sances, Clive N. Svendsen, Geraldine A. Hamilton, Gad D. Vatine, Seigo Hatata, Amanda Meyer, Norman Wen, Paul S. Kay, Chris Hinojosa, Marlesa Godoy, Alex Laperle, Berhan Mandefro, Dhruv Sareen, Dylan West
Publikováno v:
Stem Cell Reports, Vol 10, Iss 4, Pp 1222-1236 (2018)
Stem Cell Reports
Stem Cell Reports
Summary Human stem cell-derived models of development and neurodegenerative diseases are challenged by cellular immaturity in vitro. Microengineered organ-on-chip (or Organ-Chip) systems are designed to emulate microvolume cytoarchitecture and enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac9bade7d22b4174b1bfe3cfdfcd102
http://www.sciencedirect.com/science/article/pii/S2213671118301036
http://www.sciencedirect.com/science/article/pii/S2213671118301036
Autor:
Clive N. Svendsen, Todd E. Morgan, Mary Jo LaDu, V. Alexandra Moser, Caleb E. Finch, Christian J. Pike, Samuel Sances
Publikováno v:
Alzheimer's & Dementia. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8740d70d8ebedeb4a8ebd4ce83d092b0
https://doi.org/10.1016/j.jalz.2019.06.046
https://doi.org/10.1016/j.jalz.2019.06.046
Autor:
Ritchie Ho, Hynek Wichterle, Dhruv Sareen, Genevieve Gowing, Jacqueline G. O’Rourke, Anais Sahabian, Samuel Sances, Mackenzie W. Amoroso, Clive N. Svendsen, Robert H. Baloh
Publikováno v:
Nature neuroscience
Modeling amyotrophic lateral sclerosis (ALS) with human induced pluripotent stem cells (iPSCs) aims to reenact embryogenesis, maturation and aging of spinal motor neurons (spMNs) in vitro. As the maturity of spMNs grown in vitro compared to spMNs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4b9b63e28806d5ad6f8c84379aee98
http://europepmc.org/articles/PMC5003654
http://europepmc.org/articles/PMC5003654
Publikováno v:
Current stem cell reports, vol 3, iss 2
Purpose of reviewThe modeling of biological processes in vitro provides an important tool to better understand mechanisms of development and disease, allowing for the rapid testing of therapeutics. However, a critical constraint in traditional monola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459afec09b283fa917f76b49fad388e2
https://escholarship.org/uc/item/8n63w36b
https://escholarship.org/uc/item/8n63w36b
Autor:
Scott R. McKercher, Nobuki Nakanishi, Mohd Waseem Akhtar, Stuart A. Lipton, Laurence M. Brill, Shing Fai Chan, Shu-ichi Okamoto, Rameez Zaidi, Samuel Sances
Publikováno v:
The Journal of Neuroscience. 34:4640-4653
Mutations in the ataxia telangiectasia mutated (ATM) gene, which encodes a kinase critical for the normal DNA damage response, cause the neurodegenerative disorder ataxia-telangiectasia (AT). The substrates of ATM in the brain are poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9f8c58b5bedfe12bcb720261af0724
https://doi.org/10.1523/jneurosci.2510-12.2014
https://doi.org/10.1523/jneurosci.2510-12.2014