Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Samuel Sampson"'
Publikováno v:
MedEdPublish, Vol 7, Iss 3 (2018)
Introduction: Physician empathy is a highly desired characteristic in clinical practice with benefits for both patients and doctors. Increasingly, medical educators have acknowledged the importance of empathy and sought effective ways of inculcating
Externí odkaz:
https://doaj.org/article/edc13780266c431c93542bf4c95f1ae8
Autor:
Anna Larson, Taylor Bargenquast, Sara Byron, Anish Raju, Avijit Podder, Shelby Rheinschmidt, Tithi Ghosh Halder, Samuel Sampson, Sydney Adamson, Serina Ng, Kate Gutowsky, Alexis Weston, Trason Thode, Justin Moser, Erkut Borazanci, Mohan Kaadige, Nicholas Schork, Raffaella Soldi, Sunil Sharma
Publikováno v:
Cancer Research. 83:1069-1069
Background: Cancer therapy has witnessed great progress over the last 50 years with advancements in diagnostic tools to enable more precise treatment. With the development of next-generation sequencing, the field of precision oncology has been expand
Autor:
Stephen K. Horrigan, Trason Thode, Serina Ng, Sunil Sharma, Ravi Salgia, Hariprasad Vankayalapati, Kevin Drenner, Raffaella Soldi, Mohan R. Kaadige, Samuel Sampson, Ryan Rodriguez del Villar, Surinder K. Batra, Alexis Weston, Tithi Ghosh Halder, Kapil N. Bhalla
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 378:77-86
The central role of β-catenin in the Wnt pathway makes it an attractive therapeutic target for cancers driven by aberrant Wnt signaling. We recently developed a small-molecule inhibitor, BC-2059, that promotes apoptosis by disrupting the β-catenin/
Autor:
Alexis Weston, Trason Thode, Ryan Rodriguez del Villar, Serina Ng, Samuel Sampson, Shelby Rheinschmidt, Tithi Ghosh Halder, Raffaella Soldi, Mohan Kaadige, Srinivas Kasibhatla, Haiyong Han, Justin Moser, Vincent Chung, Joseph Chao, Victoria Villaflor, Daniel Von Hoff, Sunil Sharma
Publikováno v:
Cancer Research. 82:3931-3931
Purpose: Overexpression of Cyclin-Dependent Kinase 7 (CDK7) is linked to poor clinical outcomes in a variety of cancer types including AML, breast, ovarian, pancreatic, and lung cancers. CDK7 plays a dual role in tumor progression by regulating the c
Autor:
Shelby Rheinschmidt, Trason Thode, Samuel Sampson, Alexis Weston, Tithi Ghosh Halder, Serina Ng, Ryan Rodriguez del Villar, Mohan Kaadige, Anton Zernov, Marcelle Machluf, Raffaella Soldi, Sunil Sharma
Publikováno v:
Cancer Research. 82:2567-2567
Purpose: Canonical Wnt signaling is a key cascade in regulating development and stemness, however it can become dysregulated and tightly associated with oncogenesis. In human cancers, Wnt/β-catenin signaling is highly activated due to mutations of m
Autor:
Samuel Sampson, Trason Thode, Kevin Drenner, Ryan Rodriguez Del Villar, Annika Ozols, Mohan Kaadige, Alexis Weston, Serina Ng, Tithi Ghosh Halder, Shelby Rheinschmidt, David Anderson, Kevin Holden, Raffaella Soldi, Sunil Sharma
Publikováno v:
Cancer Research. 82:1048-1048
Background: Ewing's Sarcoma (ES) is a rare and aggressive pediatric bone tumor that is driven by a chromosomal translocation and fusion between EWS and FLI1 genes resulting in a chimeric protein. Nearly 85% of ES cases express the EWS/FLI protein whi
Autor:
Tithi Ghosh Halder, Shelby Rheinschmidt, Trason Thode, Samuel Sampson, Ryan Rodriguez del Villar, Serina Ng, Alexis Weston, Mohan Kaadige, Jeffery Trent, John Altin, Justin Moser, Erkut Borazanci, Michael Gordon, Anna Larson, Raffaella Soldi, Sunil Sharma
Publikováno v:
Cancer Research. 82:1878-1878
The interaction between tumor cells and immune system has been studied mostly in animal models and co-cultures with cell lines. However, it is difficult to study the unique features of human immune cells in mice, and cell lines are often transformed