Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Samuel S.-H. Wang"'
Autor:
Jessica L. Verpeut, Silke Bergeler, Mikhail Kislin, F. William Townes, Ugne Klibaite, Zahra M. Dhanerawala, Austin Hoag, Sanjeev Janarthanan, Caroline Jung, Junuk Lee, Thomas J. Pisano, Kelly M. Seagraves, Joshua W. Shaevitz, Samuel S.-H. Wang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract The cerebellum regulates nonmotor behavior, but the routes of influence are not well characterized. Here we report a necessary role for the posterior cerebellum in guiding a reversal learning task through a network of diencephalic and neocor
Externí odkaz:
https://doaj.org/article/7160c3afc36a42c19ff9f54f35d500d3
Autor:
Ugne Klibaite, Mikhail Kislin, Jessica L. Verpeut, Silke Bergeler, Xiaoting Sun, Joshua W. Shaevitz, Samuel S.-H. Wang
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract Background Repetitive action, resistance to environmental change and fine motor disruptions are hallmarks of autism spectrum disorder (ASD) and other neurodevelopmental disorders, and vary considerably from individual to individual. In anima
Externí odkaz:
https://doaj.org/article/68412c67206b4e4d84aeff8ae23f09cf
Autor:
Thomas J. Pisano, Austin T. Hoag, Zahra M. Dhanerawala, Sara R. Guariglia, Caroline Jung, Henk-Jan Boele, Kelly M. Seagraves, Jessica L. Verpeut, Samuel S.-H. Wang
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101289- (2022)
Summary: Transsynaptic viral tracing requires tissue sectioning, manual cell counting, and anatomical assignment, all of which are time intensive. We describe a protocol for BrainPipe, a scalable software for automated anatomical alignment and object
Externí odkaz:
https://doaj.org/article/c091740fc02a4919ade694dc767b0725
Autor:
Thomas J. Pisano, Zahra M. Dhanerawala, Mikhail Kislin, Dariya Bakshinskaya, Esteban A. Engel, Ethan J. Hansen, Austin T. Hoag, Junuk Lee, Nina L. de Oude, Kannan Umadevi Venkataraju, Jessica L. Verpeut, Freek E. Hoebeek, Ben D. Richardson, Henk-Jan Boele, Samuel S.-H. Wang
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109721- (2021)
Summary: Cerebellar outputs take polysynaptic routes to reach the rest of the brain, impeding conventional tracing. Here, we quantify pathways between the cerebellum and forebrain by using transsynaptic tracing viruses and a whole-brain analysis pipe
Externí odkaz:
https://doaj.org/article/f6fbdb31b6d84daba6120233ef23a1ec
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Disruption of cerebellar activity impairs working memory during evidence accumulation in mice. Here, the authors show that optogenetic perturbation of Purkinje cell activity disrupts the accurate accumulation of somatosensory information in working m
Externí odkaz:
https://doaj.org/article/de6e44beedb043dfbf9f02ffc63f0b8e
Publikováno v:
Cell Reports, Vol 6, Iss 5, Pp 792-798 (2014)
Climbing fibers (CFs) are thought to contribute to cerebellar plasticity and learning by triggering a large influx of dendritic calcium in the postsynaptic Purkinje cell (PC) to signal the occurrence of an unexpected sensory event. However, CFs fire
Externí odkaz:
https://doaj.org/article/89af0526f9454188943333a94a053511
Publikováno v:
Frontiers in Neural Circuits, Vol 6 (2012)
Recording of identified neuronal network activity using genetically encoded calcium indicators (GECIs) requires labeling that is cell type-specific and bright enough for the detection of functional signals. However, specificity and strong expression
Externí odkaz:
https://doaj.org/article/49c5d96a164c4491a2f1cfb58862ceb0
Autor:
Xiaoying Chen, Yanhua Du, Gerard Joey Broussard, Mikhail Kislin, Carla M. Yuede, Shuwei Zhang, Sabine Dietmann, Harrison Gabel, Guoyan Zhao, Samuel S.-H. Wang, Xiaoqing Zhang, Azad Bonni
Publikováno v:
Nature
Cellular diversification is critical for specialized functions of the brain including learning and memory(1). Single cell RNA-sequencing facilitates transcriptomic profiling of distinct major types of neurons(2-4), but divergence of transcriptomic pr
Autor:
Talmo D. Pereira, Nathaniel Tabris, Arie Matsliah, David M. Turner, Junyu Li, Shruthi Ravindranath, Eleni S. Papadoyannis, Edna Normand, David S. Deutsch, Z. Yan Wang, Grace C. McKenzie-Smith, Catalin C. Mitelut, Marielisa Diez Castro, John D’Uva, Mikhail Kislin, Dan H. Sanes, Sarah D. Kocher, Samuel S.-H. Wang, Annegret L. Falkner, Joshua W. Shaevitz, Mala Murthy
Publikováno v:
Nature Methods. 19:486-495
The desire to understand how the brain generates and patterns behavior has driven rapid methodological innovation in tools to quantify natural animal behavior. While advances in deep learning and computer vision have enabled markerless pose estimatio
Autor:
Aleksandra Badura, Jessica L Verpeut, Julia W Metzger, Talmo D Pereira, Thomas J Pisano, Ben Deverett, Dariya E Bakshinskaya, Samuel S-H Wang
Publikováno v:
eLife, Vol 7 (2018)
Cognitive and social capacities require postnatal experience, yet the pathways by which experience guides development are unknown. Here we show that the normal development of motor and nonmotor capacities requires cerebellar activity. Using chemogene
Externí odkaz:
https://doaj.org/article/1f2dd36d64b84f80ae27f05c6db943d3