Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Samuel S. W. Szeto"'
1
Implementation of a multiple‐fraction concatenation strategy in an online two‐dimensional high‐/low‐pH reversed‐phase/reversed‐phase liquid chromatography platform for qualitative and quantitative shotgun proteomic analyses
Autor: Ivan K. Chu, Mengzhu Li, Ricky P. W. Kong, Samuel S. W. Szeto, Henry C. H. Law
Publikováno v: Journal of Mass Spectrometry. 56
Multidimensional liquid chromatography is the mainstay separation technique used for shotgun proteomic analyses. The application of a multiple-fraction concatenation (MFC) strategy can result in a more disperse and consistent peptide elution profile
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05308fbf1a18afd053e5f982eae066bc
https://doi.org/10.1002/jms.4591
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2
Characterization of the Molecular Mechanisms Underlying the Chronic Phase of Stroke in a Cynomolgus Monkey Model of Induced Cerebral Ischemia
Autor: Leong Ting Lui, Henry C. H. Law, Zaijun Zhang, Simon Ming-Yuen Lee, K. W. Michael Siu, Quan Quan, Yuqiang Wang, Samuel S. W. Szeto, Ivan K. Chu, Chengyou Zheng, Olga Krakovska, Yun Zhao
Publikováno v: Journal of Proteome Research. 16:1150-1166
Stroke is one of the main causes of mortality and long-term disability worldwide. The pathophysiological mechanisms underlying this disease are not well understood, particularly in the chronic phase after the initial ischemic episode. In this study,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93426dd4bf298b1cfb4b2a0fd29b0345
https://doi.org/10.1021/acs.jproteome.6b00651
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3
Fully Automated Multidimensional Reversed-Phase Liquid Chromatography with Tandem Anion/Cation Exchange Columns for Simultaneous Global Endogenous Tyrosine Nitration Detection, Integral Membrane Protein Characterization, and Quantitative Proteomics Mapping in Cerebral Infarcts
Autor: Quan Quan, Ivan K. Chu, Yuqiang Wang, Samuel S. W. Szeto, Henry C. H. Law, Zaijun Zhang
Publikováno v: Analytical Chemistry. 87:10015-10024
Protein tyrosine nitration (PTN) is a signature hallmark of radical-induced nitrative stress in a wide range of pathophysiological conditions, with naturally occurring abundances at substoichiometric levels. In this present study, a fully automated f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c1572c1dfb25760f341655059cbb0d
https://doi.org/10.1021/acs.analchem.5b02619
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4
A versatile reversed phase-strong cation exchange-reversed phase (RP–SCX–RP) multidimensional liquid chromatography platform for qualitative and quantitative shotgun proteomics
Autor: Henry C. H. Law, Simon Ming-Yuen Lee, Ivan K. Chu, Guohui Li, Herman C. Lam, Quan Quan, Zaijun Zhang, Ricky P. W. Kong, Yun Zhao, Yuqiang Wang, Samuel S. W. Szeto
Publikováno v: The Analyst. 140:1237-1252
An automatable, robust, high-performance online multidimensional liquid chromatography (MDLC) platform comprising of pH 10 reversed-phase (RP), strong cation exchange (SCX), and pH 2 RP separation stages has been integrated into a modified commercial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758d1dbe4f51ca55743cdca0306bebda
https://doi.org/10.1039/c4an01893a
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5
Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy
Autor: Michael K. W. Siu, Henry C. H. Law, Gaoxiao Zhang, Eiketsu Sho, Samuel S. W. Szeto, Pei Yu, Simon Ming-Yuen Lee, Yuqiang Wang, Quan Quan, Guohui Li, Ivan K. Chu, Yewei Sun, Zaijun Zhang
Publikováno v: Scientific Reports
TBN, a novel tetramethylpyrazine derivative armed with a powerful free radical-scavenging nitrone moiety, has been reported to reduce cerebral infarction in rats through multi-functional mechanisms of action. Here we study the therapeutic effects of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fd7d774232e1f32b48b86de1c12983
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6
Discovery, Synthesis, and Functional Characterization of a Novel Neuroprotective Natural Product from the Fruit of Alpinia oxyphylla for use in Parkinson's Disease Through LC/MS-Based Multivariate Data Analysis-Guided Fractionation
Autor: Quan Quan, Zaijun Zhang, Samuel S. W. Szeto, Herman H.C. Lam, Ivan K. Chu, Guohui Li, Ren-Wang Jiang, Simon Ming-Yuen Lee, Shuai Yuan, Wing Tak Wong
Publikováno v: Journal of proteome research. 15(8)
Herein we report the discovery of a novel lead compound, oxyphylla A [(R)-4-(2-hydroxy-5-methylphenyl)-5-methylhexanoic acid] (from the fruit of Alpinia oxyphylla), which functions as a neuroprotective agent against Parkinson's disease. To identify a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba94f437888d63ddd180eda769fec7e
https://pubmed.ncbi.nlm.nih.gov/27246451
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7
Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease
Autor: Yuqiang Wang, Cheong Meng Chong, Yifan Han, Simon Ming-Yuen Lee, Quan Quan, Wei Cui, Samuel S. W. Szeto, Baojian Guo, Chen Huang, Ivan K. Chu, K.W. Michael Siu, Guohui Li, Zaijun Zhang
Publikováno v: Free radical biologymedicine. 84
Polypharmacology-based strategies using drug combinations with different mechanisms of action are gaining increasing attention as a novel methodology to discover potentially innovative medicines for neurodegenerative disorders. We used this approach
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a12191264cddcdbf18278adabf50a1
https://pubmed.ncbi.nlm.nih.gov/25769424
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