Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Samuel S. W. Szeto"'
Publikováno v:
Journal of Mass Spectrometry. 56
Multidimensional liquid chromatography is the mainstay separation technique used for shotgun proteomic analyses. The application of a multiple-fraction concatenation (MFC) strategy can result in a more disperse and consistent peptide elution profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05308fbf1a18afd053e5f982eae066bc
https://doi.org/10.1002/jms.4591
https://doi.org/10.1002/jms.4591
Autor:
Leong Ting Lui, Henry C. H. Law, Zaijun Zhang, Simon Ming-Yuen Lee, K. W. Michael Siu, Quan Quan, Yuqiang Wang, Samuel S. W. Szeto, Ivan K. Chu, Chengyou Zheng, Olga Krakovska, Yun Zhao
Publikováno v:
Journal of Proteome Research. 16:1150-1166
Stroke is one of the main causes of mortality and long-term disability worldwide. The pathophysiological mechanisms underlying this disease are not well understood, particularly in the chronic phase after the initial ischemic episode. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93426dd4bf298b1cfb4b2a0fd29b0345
https://doi.org/10.1021/acs.jproteome.6b00651
https://doi.org/10.1021/acs.jproteome.6b00651
Publikováno v:
Analytical Chemistry. 87:10015-10024
Protein tyrosine nitration (PTN) is a signature hallmark of radical-induced nitrative stress in a wide range of pathophysiological conditions, with naturally occurring abundances at substoichiometric levels. In this present study, a fully automated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c1572c1dfb25760f341655059cbb0d
https://doi.org/10.1021/acs.analchem.5b02619
https://doi.org/10.1021/acs.analchem.5b02619
Autor:
Henry C. H. Law, Simon Ming-Yuen Lee, Ivan K. Chu, Guohui Li, Herman C. Lam, Quan Quan, Zaijun Zhang, Ricky P. W. Kong, Yun Zhao, Yuqiang Wang, Samuel S. W. Szeto
Publikováno v:
The Analyst. 140:1237-1252
An automatable, robust, high-performance online multidimensional liquid chromatography (MDLC) platform comprising of pH 10 reversed-phase (RP), strong cation exchange (SCX), and pH 2 RP separation stages has been integrated into a modified commercial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758d1dbe4f51ca55743cdca0306bebda
https://doi.org/10.1039/c4an01893a
https://doi.org/10.1039/c4an01893a
Autor:
Michael K. W. Siu, Henry C. H. Law, Gaoxiao Zhang, Eiketsu Sho, Samuel S. W. Szeto, Pei Yu, Simon Ming-Yuen Lee, Yuqiang Wang, Quan Quan, Guohui Li, Ivan K. Chu, Yewei Sun, Zaijun Zhang
Publikováno v:
Scientific Reports
TBN, a novel tetramethylpyrazine derivative armed with a powerful free radical-scavenging nitrone moiety, has been reported to reduce cerebral infarction in rats through multi-functional mechanisms of action. Here we study the therapeutic effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fd7d774232e1f32b48b86de1c12983
Autor:
Quan Quan, Zaijun Zhang, Samuel S. W. Szeto, Herman H.C. Lam, Ivan K. Chu, Guohui Li, Ren-Wang Jiang, Simon Ming-Yuen Lee, Shuai Yuan, Wing Tak Wong
Publikováno v:
Journal of proteome research. 15(8)
Herein we report the discovery of a novel lead compound, oxyphylla A [(R)-4-(2-hydroxy-5-methylphenyl)-5-methylhexanoic acid] (from the fruit of Alpinia oxyphylla), which functions as a neuroprotective agent against Parkinson's disease. To identify a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba94f437888d63ddd180eda769fec7e
https://pubmed.ncbi.nlm.nih.gov/27246451
https://pubmed.ncbi.nlm.nih.gov/27246451
Autor:
Yuqiang Wang, Cheong Meng Chong, Yifan Han, Simon Ming-Yuen Lee, Quan Quan, Wei Cui, Samuel S. W. Szeto, Baojian Guo, Chen Huang, Ivan K. Chu, K.W. Michael Siu, Guohui Li, Zaijun Zhang
Publikováno v:
Free radical biologymedicine. 84
Polypharmacology-based strategies using drug combinations with different mechanisms of action are gaining increasing attention as a novel methodology to discover potentially innovative medicines for neurodegenerative disorders. We used this approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a12191264cddcdbf18278adabf50a1
https://pubmed.ncbi.nlm.nih.gov/25769424
https://pubmed.ncbi.nlm.nih.gov/25769424
Publikováno v:
Journal of Proteome Research; Dec2010, Vol. 9 Issue 12, p6729-6739, 11p
Autor:
Law, Henry C.H.1 (AUTHOR), Kong, Ricky P.W.1 (AUTHOR), Li, Mengzhu1 (AUTHOR), Szeto, Samuel S.W.1 (AUTHOR), Chu, Ivan K.1 (AUTHOR) ivankchu@hku.hk
Publikováno v:
Journal of Mass Spectrometry. Apr2021, Vol. 56 Issue 4, p1-9. 9p.
Publikováno v:
LC-GC Europe. May2016, Vol. 29 Issue 5, p268-276. 9p.