Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Samuel S. Cho"'
Autor:
Caroline E. Kuczynski, Christopher D. Porada, Anthony Atala, Samuel S. Cho, Graça Almeida-Porada
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Sickle cell disease (SCD) affects millions worldwide, yet there are few therapeutic options. To develop effective treatments, preclinical models that recapitulate human physiology and SCD pathophysiology are needed. SCD arises from a single
Externí odkaz:
https://doaj.org/article/5b1dcff094484a8ea1c2d3aca17ce1a5
Autor:
Eda Koculi, Samuel S. Cho
Publikováno v:
Biochemistry
23S ribosomal RNA (rRNA) of Escherichia coli 50S large ribosome subunit contains 26 post-transcriptionally modified nucleosides. Here, we determine the extent of modifications in the 35S and 45S large subunit intermediates, accumulating in cells expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b615cbf380c8d4806751931af14f54a4
https://doi.org/10.1021/acs.biochem.2c00096
https://doi.org/10.1021/acs.biochem.2c00096
Publikováno v:
The journal of physical chemistry. B.
Trimethylamine N-oxide (TMAO) is an osmolyte that accumulates in cells in response to osmotic stress. TMAO stabilizes proteins by the entropic stabilization mechanism, which pictures TMAO as a nano-crowder that predominantly destabilizes the unfolded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018d0ed52333059980ef2df043c4e5d6
https://pubmed.ncbi.nlm.nih.gov/36602908
https://pubmed.ncbi.nlm.nih.gov/36602908
Autor:
Adam T. Green, Amanda J. Pickard, Rongzhong Li, Alexander D. MacKerell, Ulrich Bierbach, Samuel S. Cho
Publikováno v:
J Phys Chem B
DNA G-quadruplexes in human telomeres and gene promoters are being extensively studied for their role in controlling the growth of cancer cells. G-quadruplexes have been unambiguously shown to exist both in vitro and in vivo, including in the guanine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4495938a7e3c1aa2ee97f239c5f905c8
https://pubmed.ncbi.nlm.nih.gov/35026949
https://pubmed.ncbi.nlm.nih.gov/35026949
Autor:
Adam T. Green, Samuel S. Cho
Publikováno v:
Biophysical Journal. 121:66a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c47ca8280199da4fb2cc0cf2e19e56e
https://doi.org/10.1016/j.bpj.2021.11.2399
https://doi.org/10.1016/j.bpj.2021.11.2399
Autor:
Minh Tam Nguyen, Thanh Tung Nguyen, Duy Bac Nguyen, Thi Mai Nguyen, Kim Ngan Nguyen, Van Nhat Minh Ngo, Van Dieu Nguyen, Ngoc Anh Tran, Mulias Lian, Arnold S. C. Tan, Samuel S. Chong, Tien Truong Dang
Publikováno v:
Thrombosis Journal, Vol 21, Iss 1, Pp 1-7 (2023)
Abstract Background Hemophilia A (HEMA) is an X-linked bleeding disorder caused by reduced/absent coagulation factor VIII expression, as a result of pathogenic variants in the F8 gene. Preimplantation prevention of HEMA should ideally include direct
Externí odkaz:
https://doaj.org/article/16b781413ad24e16b88364856c3dd713
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 7, Pp 15872-15902 (2015)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
While tRNA and aminoacyl-tRNA synthetases are classes of biomolecules that have been extensively studied for decades, the finer details of how they carry out their fundamental biological functions in protein synthesis remain a challenge. Recent molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbab0e341f3498c77e397bf4856d82a
https://doi.org/10.3390/ijms160715872
https://doi.org/10.3390/ijms160715872
Publikováno v:
Modeling, Methodologies and Tools for Molecular and Nano-scale Communications ISBN: 9783319506869
The development and advancement of nanomedicine has opened up many exciting, new applications of nanoparticles such as sensing, imaging, delivery, and therapy. However, their ability to readily enter cells and organelles that allow these nanomedical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1ae9c4d105966beeb384b21a20744ad
https://doi.org/10.1007/978-3-319-50688-3_10
https://doi.org/10.1007/978-3-319-50688-3_10
Autor:
Ashley J. W. Lim, C. Tera Tyniana, Lee Jin Lim, Justina Wei Lynn Tan, Ee Tzun Koh, TTSH Rheumatoid Arthritis Study Group, Samuel S. Chong, Chiea Chuen Khor, Khai Pang Leong, Caroline G. Lee
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background The popular statistics-based Genome-wide association studies (GWAS) have provided deep insights into the field of complex disorder genetics. However, its clinical applicability to predict disease/trait outcomes remains unclear as
Externí odkaz:
https://doaj.org/article/87deb690648f4aca92310084051267ce
Publikováno v:
Israel Journal of Chemistry. 54:1152-1164
Although the main features of the protein folding problem are coming into clearer focus, the microscopic viewpoint of nucleic acid folding mechanisms is only just beginning to be addressed. Experiments, theory, and simulations are pointing to complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::167f11da4932338dbded6e4844c14686
https://doi.org/10.1002/ijch.201400022
https://doi.org/10.1002/ijch.201400022