Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Samuel S Chong"'
Autor:
Maulana Bachtiar, Yu Jin, Jingbo Wang, Tin Wee Tan, Samuel S Chong, Kenneth H K Ban, Caroline G L Lee
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224089 (2019)
Population variation in disease and other phenotype are partly attributed to single nucleotide polymorphisms (SNPs) in the human genome. Due to selection pressure, two individuals from the same ancestral population have more genetic similarity compar
Externí odkaz:
https://doaj.org/article/d638096352e9407883782348167502b6
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180984 (2017)
Molecular diagnosis of Huntington disease (HD) is currently performed by fluorescent repeat-flanking or triplet-primed PCR (TP-PCR) with capillary electrophoresis (CE). However, CE requires multiple post-PCR steps and may result in high cost in high-
Externí odkaz:
https://doaj.org/article/153914eea7724dd8aa2e44114a9685dd
Autor:
Grace X Y Lim, Minli Yeo, Yvonne Y Koh, Tri Indah Winarni, Indhu-Shree Rajan-Babu, Samuel S Chong, Sultana M H Faradz, Ming Guan
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173279 (2017)
In the present study, we evaluated a commercially available TP-PCR-based assay, the FastFraXTM FMR1 Sizing kit, as a test in quantifying the number of CGG repeats in the FMR1 gene. Based on testing with well characterized DNA samples from Coriell, th
Externí odkaz:
https://doaj.org/article/b8f79a6d317e4f90979273ec384fb1ae
Autor:
C H W M R Bhagya Chandrasekara, W S Sulochana Wijesundera, Hemamali N Perera, Samuel S Chong, Indhu-Shree Rajan-Babu
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145537 (2015)
Fragile X syndrome (FXS) is the commonest cause of inherited mental retardation and clinically presents with learning, emotional and behaviour problems. FXS is caused by expansion of cytosine-guanine-guanine (CGG) repeats present in the 5' untranslat
Externí odkaz:
https://doaj.org/article/d5bb2c86de6b41729eb9ee05dcd33d5d
Autor:
Jingbo Wang, Xu Wang, Mingjue Zhao, Su Pin Choo, Sin Jen Ong, Simon Y K Ong, Samuel S Chong, Yik Ying Teo, Caroline G L Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111694 (2014)
5-Fluorouracil (5-FU) and its pro-drug Capecitabine have been widely used in treating colorectal cancer. However, not all patients will respond to the drug, hence there is a need to develop reliable early predictive biomarkers for 5-FU response. Here
Externí odkaz:
https://doaj.org/article/7807bdbfd8e248c5a778e2e1156984e4
Autor:
Tao Wu, Holger Schwender, Ingo Ruczinski, Jeffrey C Murray, Mary L Marazita, Ronald G Munger, Jacqueline B Hetmanski, Margaret M Parker, Ping Wang, Tanda Murray, Margaret Taub, Shuai Li, Richard J Redett, M Daniele Fallin, Kung Yee Liang, Yah Huei Wu-Chou, Samuel S Chong, Vincent Yeow, Xiaoqian Ye, Hong Wang, Shangzhi Huang, Ethylin W Jabs, Bing Shi, Allen J Wilcox, Sun Ha Jee, Alan F Scott, Terri H Beaty
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88088 (2014)
Nonsyndromic cleft palate (CP) is one of the most common human birth defects and both genetic and environmental risk factors contribute to its etiology. We conducted a genome-wide association study (GWAS) using 550 CP case-parent trios ascertained in
Externí odkaz:
https://doaj.org/article/15d955c4715d4d6eac28bc45d965d600
Autor:
Qianqian Chen, Hong Wang, Holger Schwender, Tianxiao Zhang, Jacqueline B Hetmanski, Yah-Huei Wu Chou, Xiaoqian Ye, Vincent Yeow, Samuel S Chong, Bo Zhang, Ethylin Wang Jabs, Margaret M Parker, Alan F Scott, Terri H Beaty
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109038 (2014)
Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common disorder with complex etiology. The Bone Morphogenetic Protein 4 gene (BMP4) has been considered a prime candidate gene with evidence accumulated from animal experimental studi
Externí odkaz:
https://doaj.org/article/b15983e156d84fbfbb240d7b0046ca3b
Autor:
Qianqian Chen, Hong Wang, Jacqueline B Hetmanski, Tianxiao Zhang, Ingo Ruczinski, Holger Schwender, Kung Yee Liang, M Daniele Fallin, Richard J Redett, Gerald V Raymond, Yah-Huei Wu Chou, Philip Kuo-Ting Chen, Vincent Yeow, Samuel S Chong, Felicia S H Cheah, Ethylin Wang Jabs, Alan F Scott, Terri H Beaty
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35347 (2012)
The Bone Morphogenetic Protein 4 gene (BMP4) is located in chromosome 14q22-q23 which has shown evidence of linkage for isolated nonsyndromic cleft lip with or without cleft palate (NSCL/P) in a genome wide linkage analysis of human multiplex familie
Externí odkaz:
https://doaj.org/article/8afa1708bd2c4ecfbf85f443208ad079
Autor:
Mulias Lian, Vivienne J. Tan, Riho Taguchi, Mingjue Zhao, Gui-Ping Phang, Arnold S. Tan, Shuling Liu, Caroline G. Lee, Samuel S. Chong
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8073 (2024)
Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a neurodegenerative disorder caused by the ATXN3 CAG repeat expansion. Preimplantation genetic testing for monogenic disorders (PGT-M) of SCA3/MJD should include reliable repeat exp
Externí odkaz:
https://doaj.org/article/3e51c8e9494d4f52a1ba306d24de690a
Autor:
Caroline G. Lee, Oi Lian Kon, London Lucien Ooi, Samuel S. Chong, Sheng Lim, Feiyang Huang, Samuel Y.S. Wong, Lee Jin Lim
Next-generation sequencing has uncovered thousands of long noncoding RNAs (lncRNA). Many are reported to be aberrantly expressed in various cancers, including hepatocellular carcinoma (HCC), and play key roles in tumorigenesis. This review provides a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d323c535adb375a189c3587ae9e65745
https://doi.org/10.1158/0008-5472.c.6511284.v1
https://doi.org/10.1158/0008-5472.c.6511284.v1
