Výsledky vyhledávání

Durable complete response rates following radiotherapy and immunotherapy combination in recurrent and metastatic head and neck squamous cell carcinoma: A retrospective single centre cohort study

Autor: Raj Khera, Laura Feeney, Martin Swinton, Samuel Rack, Andrew Sykes, Robert Metcalf

Publikováno v: Khera, R, Feeney, L, Swinton, M, Rack, S, Sykes, A & Metcalf, R 2022, ' Durable complete response rates following radiotherapy and immunotherapy combination in recurrent and metastatic head and neck squamous cell carcinoma: A retrospective single centre cohort study ', Clinical Otolaryngology . https://doi.org/10.1111/coa.13954

Key Points 1. This study reports clinical outcome data on 76 patients with platinum-resistant recurrent or metastatic head and neck squamous carcinoma treated with nivolumab, making it the largest published single centre case series of its kind. 2. R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13c18cd55c1e0efa755f40b812552a4
https://doi.org/10.22541/au.164569571.16196481/v1

Zobrazit plný text záznamu

Evaluation of the Clinical Utility of Genomic Profiling to Inform Selection of Clinical Trial Therapy in Salivary Gland Cancer

Autor: Samuel Rack, Laura Feeney, Brindley Hapuarachi, Helen Adderley, Laura Woodhouse, Guy Betts, George J. Burghel, Kevin J. Harrington, Robert Metcalf

Publikováno v: Cancers; Volume 14; Issue 5; Pages: 1133

For most patients with salivary gland cancer, there are no effective standard systemic therapies. Although clinical trials of biomarker-led drug therapies have delivered significant recent advances, there remains a need to understand the clinical uti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0895dbb35d4d91904ac22c0772fb194
https://pubmed.ncbi.nlm.nih.gov/35267442

Zobrazit plný text záznamu

Plný text ve formátu HTML

Cumulative Antibiotic Use Significantly Decreases Efficacy of Checkpoint Inhibitors in Patients with Advanced Cancer

Autor: Matthew G Krebs, Louise Carter, Paul Lorigan, Nadina Tinsley, Cong Zhou, Samuel Rack, Fiona H Blackhall, Natalie Cook, Grace Fangmin Tan, Donna M. Graham, Fiona C Thistlethwaite

Publikováno v: Tinsley, N, Zhou, C, Tan, G, Rack, S, Lorigan, P, Blackhall, F, Krebs, M, Carter, L, Thistlethwaite, F, Graham, D & Cook, N 2019, ' Cumulative Antibiotic Use Significantly Decreases Efficacy of Checkpoint Inhibitors in Patients with Advanced Cancer ', The oncologist . https://doi.org/10.1634/theoncologist.2019-0160

Background With the advent of immunotherapy, substantial progress has been made in improving outcomes for patients with advanced cancer. However, not all patients benefit equally from treatment, and confounding immune-related issues may have an impac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c13f92282922ea40832fd36a1dc644
https://doi.org/10.1634/theoncologist.2019-0160

Zobrazit plný text záznamu

The prevalence and prognostic impact of mutations promoting chromatin remodelling dysregulation in non-resectable or recurrent/metastatic adenoid cystic carcinoma

Autor: Samuel Rack, Laura Feeney, Hitesh Mistry, Guy Betts, Kevin Joseph Harrington, Robert Metcalf

Publikováno v: Journal of Clinical Oncology. 40:6087-6087

6087 Background: Few effective drug therapies exist for patients with recurrent/metastatic (R/M) adenoid cystic carcinoma (ACC). Mutations in genes encoding chromatin remodelling proteins are described in almost 50% of ACC patients (pts). Novel drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0183ee9f37d37284bf2ab7547246456
https://doi.org/10.1200/jco.2022.40.16_suppl.6087

Zobrazit plný text záznamu

Nomogram to predict duration of clinical benefit from nivolumab in platinum resistant, recurrent/metastatic head and neck squamous cell carcinoma

Autor: Laura Feeney, Samuel Rack, Hitesh Mistry, Becky Bola, Andrew McPartlin, Andrew Sykes, Robert Metcalf

Publikováno v: Journal of Clinical Oncology. 40:e18016-e18016

e18016 Background: Immune checkpoint blockade of the programmed death-1 receptor (PD1) with nivolumab improves survival for patients with platinum resistant recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, response rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9048c6417b62f7534b286eed37a4711
https://doi.org/10.1200/jco.2022.40.16_suppl.e18016

Zobrazit plný text záznamu

The utility of TP53 and PIK3CA mutations as prognostic biomarkers in salivary adenoid cystic carcinoma

Autor: Clare Hodgson, Andrew J Wallace, Robert Metcalf, Guy N J Betts, Brindley Sonal Hapuarachi, Laura Feeney, Tracy Hussell, Kevin J. Harrington, Helen Adderley, Samuel Rack, David H. J. Morgan

Publikováno v: Adderley, H, Rack, S, Hapuarachi, B, Feeney, L, Morgan, D, Hussell, T, Wallace, A J, Betts, G, Hodgson, C, Harrington, K & Metcalf, R 2021, ' The utility of TP53 and PIK3CA mutations as prognostic biomarkers in salivary adenoid cystic carcinoma ', Oral Oncology, vol. 113, 105095 . https://doi.org/10.1016/j.oraloncology.2020.105095

OBJECTIVES: Despite wide excision and post-operative irradiation, loco-regional and/or metastatic recurrence is a significant clinical problem in salivary adenoid cystic carcinoma (SACC). Reliable biomarkers are required to tailor post-treatment surv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e49bbf83042417c7b0f26bc7f9a50e8
https://pubmed.ncbi.nlm.nih.gov/33290961

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání