Zobrazeno 1 - 10
of 302
pro vyhledávání: '"Samuel R. Denmeade"'
Autor:
Mark C. Markowski, Mary-Ellen Taplin, Rahul Aggarwal, Laura A. Sena, Hao Wang, Hanfei Qi, Aliya Lalji, Victoria Sinibaldi, Michael A. Carducci, Channing J. Paller, Catherine H. Marshall, Mario A. Eisenberger, David E. Sanin, Srinivasan Yegnasubramanian, Carolina Gomes-Alexandre, Busra Ozbek, Tracy Jones, Angelo M. De Marzo, Samuel R. Denmeade, Emmanuel S. Antonarakis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Cyclic high-dose testosterone administration, known as bipolar androgen therapy (BAT), is a treatment strategy for patients with metastatic castration-resistant prostate cancer (mCRPC). Here, we report the results of a multicenter, single ar
Externí odkaz:
https://doaj.org/article/48b46172ca5a4aa0833d3da4c8f53c4c
Autor:
Mark C. Markowski, Hao Wang, Angelo M. De Marzo, Michael T. Schweizer, Emmanuel S. Antonarakis, Samuel R. Denmeade
Publikováno v:
European Urology Open Science, Vol 41, Iss , Pp 112-115 (2022)
Bipolar androgen therapy (BAT) relies on oscillating levels of serum testosterone as a way to treat patients with metastatic castration-resistant prostate cancer (mCRPC). Aggressive-variant prostate cancers typically require combination chemotherapy
Externí odkaz:
https://doaj.org/article/4bc2a24fd1db4ec6b43aeedc41d28c67
Autor:
Laura A. Sena, Rajendra Kumar, David E. Sanin, Elizabeth A. Thompson, D. Marc Rosen, Susan L. Dalrymple, Lizamma Antony, Yuhan Yang, Carolina Gomes-Alexandre, Jessica L. Hicks, Tracy Jones, Kiara A. Bowers, Jillian N. Eskra, Jennifer Meyers, Anuj Gupta, Alyza Skaist, Srinivasan Yegnasubramanian, Jun Luo, W. Nathaniel Brennen, Sushant K. Kachhap, Emmanuel S. Antonarakis, Angelo M. De Marzo, John T. Isaacs, Mark C. Markowski, Samuel R. Denmeade
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Testosterone is the canonical growth factor of prostate cancer but can paradoxically suppress its growth when present at supraphysiological levels. We have previously demonstrated that the cyclical administration of supraphysiological androgen (SPA),
Externí odkaz:
https://doaj.org/article/1190b8e3606d4217ab6c491c95462033
Publikováno v:
Asian Journal of Urology, Vol 6, Iss 1, Pp 99-108 (2019)
Localized prostate cancer is curable via annihilation of the entire cancer neighborhood by surgery or local radiation. Unfortunately, once metastatic, no available therapy is curative. The vast majority will die despite aggressive systemic combinatio
Externí odkaz:
https://doaj.org/article/298316599c0f45169bd11ccfa803c5ea
Autor:
Timothy E. G. Krueger, Daniel L. J. Thorek, Samuel R. Denmeade, John T. Isaacs, W. Nathaniel Brennen
Publikováno v:
Stem Cells Translational Medicine, Vol 7, Iss 9, Pp 651-663 (2018)
Abstract The development of mesenchymal stem cells (MSCs) as cell‐based drug delivery vectors for numerous clinical indications, including cancer, has significant promise. However, a considerable challenge for effective translation of these approac
Externí odkaz:
https://doaj.org/article/7559fd62178645e6b65db7694242911c
Publikováno v:
Molecules, Vol 26, Iss 24, p 7469 (2021)
Søren Brøgger Christensen isolated and characterized the cell-penetrant sesquiterpene lactone Thapsigargin (TG) from the fruit Thapsia garganica. In the late 1980s/early 1990s, TG was supplied to multiple independent and collaborative groups. Using
Externí odkaz:
https://doaj.org/article/73b6c006ea3d4efd966c5acdc0d1edd1
Autor:
W. Nathaniel Brennen, Michael T. Schweizer, Hao Wang, Trinity J. Bivalacqua, Alan W. Partin, Su Jin Lim, Carolyn Chapman, Rehab Abdallah, Oren Levy, Neil A. Bhowmick, Jeffrey M. Karp, Angelo De Marzo, John T. Isaacs, Samuel R. Denmeade
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 7, Pp 739-740 (2019)
Externí odkaz:
https://doaj.org/article/6b6ca46c945043b3813ecfc9bbd42964
The testosterone paradox of advanced prostate cancer: mechanistic insights and clinical implications
Publikováno v:
Nat Rev Urol
The discovery of the benefits of castration for prostate cancer treatment in 1941 led to androgen deprivation therapy, which remains a mainstay of the treatment of men with advanced prostate cancer. However, as early as this original publication, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc14edf78c6212f4032f520064ca5612
https://doi.org/10.1038/s41585-022-00686-y
https://doi.org/10.1038/s41585-022-00686-y
Autor:
Laura A. Sena, Tingchang Wang, Hao Wang, Mark C. Markowski, Emmanuel S. Antonarakis, Samuel R. Denmeade
Publikováno v:
European Journal of Cancer. 181:23-25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ef6d88d73216a04352a9a4261feafbc
https://doi.org/10.1016/j.ejca.2022.12.001
https://doi.org/10.1016/j.ejca.2022.12.001
Publikováno v:
The Prostate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::112c654e11dc7554ca90c7c316ba6c85
https://doi.org/10.1002/pros.24582
https://doi.org/10.1002/pros.24582