Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Samuel P. Rowbotham"'
Autor:
Carla F. Kim, Ryan M. Hekman, Benjamin C. Blum, William D. Wallace, Eileen Fung, Steven M. Dubinett, Roderick T. Bronson, Preetida J. Bhetariya, Sharon M. Louie, Carlos Villacorta-Martin, Antonella F.M. Dost, Andrew Emili, Jane Yanagawa, Julio Sainz de Aja, Dar Heinze, Marall Vedaie, Gustavo Mostoslavsky, Gregory A. Fishbein, Mary E. Piper, Julian H. Kwan, Samuel P. Rowbotham, Linh M. Tran, Kostyantyn Krysan, Jessie Huang, Aaron L. Moye, Darrell N. Kotton
Publikováno v:
Cell stem cell, vol 27, iss 4
Cell Stem Cell
Cell Stem Cell
Summary Mutant KRAS is a common driver in epithelial cancers. Nevertheless, molecular changes occurring early after activation of oncogenic KRAS in epithelial cells remain poorly understood. We compared transcriptional changes at single-cell resoluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7ee7e1f223f34dcae0593d2b9c2b20
https://escholarship.org/uc/item/59d4j07r
https://escholarship.org/uc/item/59d4j07r
Autor:
Carla F. Kim, Rajeswara Rao Arasada, Walter Wang, David P. Carbone, Mounika U.L. Goruganthu, Samuel P. Rowbotham
Publikováno v:
Cold Spring Harbor Perspectives in Medicine. :a041270
It is now widely accepted that stem cells exist in various cancers, including lung cancer, which are referred to as cancer stem cells (CSCs). CSCs are defined in this context as the subset of tumor cells with the ability to form tumors in serial tran
Autor:
Joanne M. Berry, Pooja T. Desai, Haikuo Zhang, Chunxiao Xu, Samuel P. Rowbotham, Carla F. Kim, Peter S. Hammerman, Kwok-Kin Wong, Victor E. Marquez, Yi-Jang Lin, Christine M. Fillmore
Publikováno v:
Nature
Non-small-cell lung cancer is the leading cause of cancer-related death worldwide. Chemotherapies such as the topoisomerase II (TopoII) inhibitor etoposide effectively reduce disease in a minority of patients with this cancer; therefore, alternative
Autor:
Carla F. Kim, Samuel P. Rowbotham
Publikováno v:
Cell. 169(4)
Tissue stem cells contribute to tissue regeneration and wound repair through cellular programs that can be hijacked by cancer cells. Here, we investigate such a phenomenon in skin, where during homeostasis, stem cells of epidermis and hair follicle f
Publikováno v:
Journal of Thoracic Oncology. 13:S290
Author Correction: EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors
Autor:
Joanne M. Berry, Haikuo Zhang, Christine M. Fillmore, Pooja T. Desai, Victor E. Marquez, Peter S. Hammerman, Kwok-Kin Wong, Samuel P. Rowbotham, Yi-Jang Lin, Carla F. Kim, Chunxiao Xu
Publikováno v:
Nature. 563:E27-E27
We wish to correct two mutations in Supplementary Table 4 of this Letter. The NCI-H460 cell line was annotated as being mutant for TP53. NCI-H460 has been verified to be TP53 wild type by several sources1. The NCI-H2009 cell line was annotated as bei
Publikováno v:
Biology Open
Biology Open, Vol 4, Iss 12, Pp 1739-1743 (2015)
Biology Open, Vol 4, Iss 12, Pp 1739-1743 (2015)
Inactivation of Mec1, the budding yeast ATR, results in a permanent S phase arrest followed by chromosome breakage and cell death during G2/M. The S phase arrest is proposed to stem from a defect in Mec1-mediated degradation of Sml1, a conserved inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25658008be9182a14e5d311d721694be
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111962
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111962
Autor:
Christine M. Fillmore, Alexander M. Beede, Morvarid Mohseni, Zandra E. Walton, Kerstin W. Sinkevicius, Kwok-Kin Wong, Darcy E. Wagner, Samuel P. Rowbotham, Daniel J. Weiss, Stephen J. Curtis, Juliana Barrios, Fernando D. Camargo, Carla F. Kim, Daniel T. Montoro, Allison N. Lau
Metastasis is the leading cause of morbidity for lung cancer patients. Here we demonstrate that murine tumor propagating cells (TPCs) with the markers Sca1 and CD24 are enriched for metastatic potential in orthotopic transplantation assays. CD24 knoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5425c3e990a62e54c543d5446da8c170
https://europepmc.org/articles/PMC3989628/
https://europepmc.org/articles/PMC3989628/
Autor:
Carla F. Kim, Samuel P. Rowbotham
Publikováno v:
Cancer Research. 76:A39-A39
Proper epigenetic control of transcription is essential for stem cell homeostasis and is frequently disrupted in cancer, but this has not been well investigated in lung biology or lung disease. We determined to test if lung stem cells and lung cancer
Publikováno v:
Cell cycle (Georgetown, Tex.). 10(23)
Disruption of chromatin organization during replication poses a major challenge to the maintenance and integrity of genome organization. It creates the need to accurately reconstruct the chromatin landscape following DNA duplication but there is litt