Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Samuel P. Pitzen"'
ALAN is a computational approach that interprets genomic findings in the context of tumor ecosystems
Autor:
Hannah E. Bergom, Ashraf Shabaneh, Abderrahman Day, Atef Ali, Ella Boytim, Sydney Tape, John R. Lozada, Xiaolei Shi, Carlos Perez Kerkvliet, Sean McSweeney, Samuel P. Pitzen, Megan Ludwig, Emmanuel S. Antonarakis, Justin M. Drake, Scott M. Dehm, Charles J. Ryan, Jinhua Wang, Justin Hwang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Gene behavior is governed by activity of other genes in an ecosystem as well as context-specific cues including cell type, microenvironment, and prior exposure to therapy. Here, we developed the Algorithm for Linking Activity Networks (ALAN)
Externí odkaz:
https://doaj.org/article/beba2e91e3c64bb1936e18c40ebe3097
Autor:
Meixia Che, Aashi Chaturvedi, Sarah A. Munro, Samuel P. Pitzen, Alex Ling, Weijie Zhang, Josh Mentzer, Sheng-Yu Ku, Loredana Puca, Yanyun Zhu, Andries M. Bergman, Tesa M. Severson, Colleen Forster, Yuzhen Liu, Jacob Hildebrand, Mark Daniel, Ting-You Wang, Luke A. Selth, Theresa Hickey, Amina Zoubeidi, Martin Gleave, Rohan Bareja, Andrea Sboner, Wayne Tilley, Jason S. Carroll, Winston Tan, Manish Kohli, Rendong Yang, Andrew C. Hsieh, Paari Murugan, Wilbert Zwart, Himisha Beltran, R. Stephanie Huang, Scott M. Dehm
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
While many treatments for prostate cancer suppress the androgen receptor it becomes reactivated during disease progression. Here, the authors show that a KLF5 transcriptional programme is also activated during treatment and promotes migration and the
Externí odkaz:
https://doaj.org/article/0d96a02002f9414c84ce1f8008d43a91
Autor:
Mitchell G. Kluesner, Walker S. Lahr, Cara-lin Lonetree, Branden A. Smeester, Xiaohong Qiu, Nicholas J. Slipek, Patricia N. Claudio Vázquez, Samuel P. Pitzen, Emily J. Pomeroy, Madison J. Vignes, Samantha C. Lee, Samuel P. Bingea, Aneesha A. Andrew, Beau R. Webber, Branden S. Moriarity
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Base editors can inactivate splice sites or introduce stop codons into a gene sequence. Here the authors present SpliceR to design, rank, and test sgRNAs for efficient gene disruption in T cells.
Externí odkaz:
https://doaj.org/article/66661828f7814bdf8c8c049d29a4b13b
Autor:
Samuel P. Pitzen, Scott M. Dehm
Publikováno v:
Cell Cycle. 22:1303-1318
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46ffe13c0fe2857f7c7f9f256ef4bee9
https://doi.org/10.1080/15384101.2023.2206502
https://doi.org/10.1080/15384101.2023.2206502
Autor:
Sheng-Yu Ku, Theresa E. Hickey, Mark Daniel, Andries M. Bergman, Scott M. Dehm, Wilbert Zwart, Martin E. Gleave, Yuzhen Liu, Paari Murugan, Jason S. Carroll, Rendong Yang, Tesa M. Severson, Amina Zoubeidi, Samuel P. Pitzen, Colleen L. Forster, Manish Kohli, R. Stephanie Huang, Aashi Chaturvedi, Luke A. Selth, Loredana Puca, Andrea Sboner, Meixia Che, Josh Mentzer, Andrew C. Hsieh, Wayne D. Tilley, Ting-You Wang, Himisha Beltran, Winston Tan, Rohan Bareja, Alexander Ling, Sarah A. Munro, Jacob Hildebrand, Yanyun Zhu, Weijie Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Endocrine therapies for prostate cancer inhibit the androgen receptor (AR) transcription factor. In most cases, AR activity resumes during therapy and drives progression to castration-resistant prostate cancer (CRPC). However, therapy can also promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e810461d5a1464f0552fc356120259
https://doi.org/10.1038/s41467-021-26612-1
https://doi.org/10.1038/s41467-021-26612-1
Autor:
Aneesha A. Andrew, Emily J. Pomeroy, Xiaohong Qiu, Mitchell G. Kluesner, Walker S. Lahr, Cara lin Lonetree, Branden A. Smeester, Madison J. Vignes, Branden S. Moriarity, Samuel P. Pitzen, Nicholas J. Slipek, Samantha C. Lee, Samuel P. Bingea, Patricia N. Claudio Vázquez, Beau R. Webber
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
CRISPR-Cas9 cytidine and adenosine base editors (CBEs and ABEs) can disrupt genes without introducing double-stranded breaks by inactivating splice sites (BE-splice) or by introducing premature stop (pmSTOP) codons. However, no in-depth comparison of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343a074f434d56ae670a5db2b2468692
http://europepmc.org/articles/PMC8065034
http://europepmc.org/articles/PMC8065034
Autor:
Beau R. Webber, Cara-lin Lonetree, Mitchell G. Kluesner, Branden S. Moriarity, Samuel P. Pitzen, Patricia N. Claudio-Vázquez, Walker S. Lahr, Samuel P. Bingea, Aneesha A. Andrews, Samantha C. Lee, Branden A. Smeester, Madison J. Vignes
Base editors allow for precise nucleotide editing without the need for genotoxic double-stranded breaks. Prior work has used base editors to knockout genes by introducing premature stop codons or by disrupting conserved splice-sites, but no direct co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0ae0f90a96d8c1d0093cc91ba5e784
